|Description||Chlormethiazole hydrochloride is the hydrochloride salt of chlormethiazole, which is a GABAA agonist. It is a useful research chemical and is used in the study of effects of thiazole methiodide and hydrochloride fractions of thiamine upon the neuromuscular system. It is neuroprotective in a number of animal models and is used as a sedative and anticonvulsant. It prevents the degeneration of serotonergic nerve terminals induced by MDMA.|
|Purity||≥99% by HPLC|
|Synonyms||4-methyl-5-(β-chloroethyl)thiazole hydrochloride; 5-(2-Chloroethyl)-4-methylthiazole hydrochloride; Somnevrin hydrochloride|
N-ArachidonylGABA is first isolated from bovine brain. It was also found to inhibit normal responses to pain in vivo, but has not been fully characterized to da...
DMCM hydrochloride is a benzodiazepine inverse agonist exhibiting anxiogenic and potent convulsant activity.
NNC 711 is a GABA uptake inhibitor by GAT-1 with IC50 values of 0.04, 171, 1700 and 622 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1. NNC 711 is an anticonvulsantag...
MK 0343, also known as MRK-409, is a subtype-selective GABAA partial agonist (Ki values are 0.21, 0.22, 0.23 and 0.40 for α3, α1, α5 and α2 respectively). MK-03...
Org 20599 is an anaesthetic steroid. It has modulatory effects on GABAA receptors. Org 20599 is a potential theraputic for migraines and headaches.
PZ-II-029,a pyrazoloquinolinone, was reported as the first postitive modulator of GABAA α6β3γ2 subtype functionally selective ligands to date.
Pagoclone, an active (+)-enantiomer of the racemate RP 59037, is a ubtype selective partial agonist at GABAA receptor and used for the treatment of panic and an...
AA 29504 is a positive allosteric modulator of GABAA receptors with anxiolytic activity. It modulates both α4β3δ-containing extrasynaptic receptors and α1β3γ2S-...
GS 39783 is an allosteric positive modulator of GABAB receptors, decreases cocaine self-administration, blocks the rewarding properties of nicotine and produces...
U 89843A is a positive allosteric modulator of GABAA receptors. U 89843A potentiates GABA-induced Cl- currents in the α1β2γ2, α3β2γ2 and α6β2γ2 GABAA receptors....
TCS 1205 is a GABAA α2 benzodiazepine receptor agonist and GABAA α1 partial agonist in vitro (Ki = 14 and 121 nM, respectively). It displays non-sedative anxiol...
DS2 has been found to be a positive allosteric modulator of δ-GABAA receptors and could probably be useful against analgesics as well as sleep disorders.
The hydrochloride of pipequaline. Pipequaline is a non-selective GABAA receptor partial agonist that is potentially used as an anxiolytic drug of the nonbenzodi...
U 93631 is a ligand at the picrotoxin site of GABA(A) receptors, allosterically antagonizing GABA-induced Cl- currents. U-93631 causes rapid decay of gamma-amin...
Saclofen is a selective antagonist at GABAB receptors.
Etifoxine, also called as HOE 36801 or Stresam, is a positive allosteric modulator of GABAreceptors that produces anxiolytic effects by preferentially modulatin...
Isoguvacine hydrochloride is a selective GABA receptor agonist with anticonvulsant and antiepileptic effect, developed for Neuroscience research.
ZAPA sulfate acts as an agonist at low affinity GABAA receptors and is thus a useful ligand to investigate GABA receptors linked to benzodiazepine receptors. ZA...
Arbaclofen, the R-enantiomer of baclofen, is a selective gamma-amino butyric acid type B receptor agonist used for autism spectrum disorder and fragile X syndro...
(+)-Bicuculline is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels.