Chlormethiazole hydrochloride - CAS 6001-74-7
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
Molecular Weight:
GABA Receptor
Chlormethiazole hydrochloride is the hydrochloride salt of chlormethiazole, which is a GABAA agonist. It is a useful research chemical and is used in the study of effects of thiazole methiodide and hydrochloride fractions of thiamine upon the neuromuscular system. It is neuroprotective in a number of animal models and is used as a sedative and anticonvulsant. It prevents the degeneration of serotonergic nerve terminals induced by MDMA.
≥99% by HPLC
4-methyl-5-(β-chloroethyl)thiazole hydrochloride; 5-(2-Chloroethyl)-4-methylthiazole hydrochloride; Somnevrin hydrochloride
Canonical SMILES:
1.Alcohol withdrawal treatment in intoxicated vs non-intoxicated patients: a controlled open-label study with tiapride/carbamazepine, clomethiazole and diazepam.
Lucht M1, Kuehn KU, Armbruster J, Abraham G, Gaensicke M, Barnow S, Tretzel H, Freyberger HJ. Alcohol Alcohol. 2003 Mar-Apr;38(2):168-75.
AIMS AND METHODS: Alcohol withdrawal treatment efficacy of tiapride/carbamazepine (A) vs clomethiazole (B) vs diazepam (C) in non-intoxicated patients and vs tiapride/carbamazepine in intoxicated patients (D; breath alcohol concentration > or = 1 g/l) was tested (n = 127) in a controlled randomized open-label study.
2.Oxcarbazepine in combination with Tiaprid in inpatient alcohol-withdrawal--a RCT.
Croissant B1, Loeber S, Diehl A, Nakovics H, Wagner F, Kiefer F, Mann K. Pharmacopsychiatry. 2009 Sep;42(5):175-81. doi: 10.1055/s-0029-1202264. Epub 2009 Sep 1.
INTRODUCTION: Oxcarbazepine (OXC), a derivative of Carbamazepine (CBZ), may represent a solution to metabolic and side effects of CBZ treatment due to the fact that renal excretion is its major route of elimination. The goal of the study is to compare the efficacy and tolerability of OXC/Tiaprid (TIA) combination therapy to the well established Clomethiazole (CLO) therapy in an inpatient setting.
3.Treatment of alcohol withdrawal: tiapride and carbamazepine versus clomethiazole. A pilot study.
Franz M1, Dlabal H, Kunz S, Ulferts J, Gruppe H, Gallhofer B. Eur Arch Psychiatry Clin Neurosci. 2001 Aug;251(4):185-92.
In Germany, clomethiazole (CLO) and benzodiazepines are predominantly used as therapeutic agents in the treatment of the alcohol withdrawal syndrome (AWS). These agents have disadvantages such as sedation, risk of respiratory insufficiency, and cardiovascular complications as well as addictive potential. Alternatively, it could be demonstrated that both tiapride (TIA) and carbamazepine (CBZ) are efficient in the treatment of AWS with less toxicity. However, they seem to be less effective in AWS than CLO as single agents. But no systematic comparison of the combination of TIA and CBZ against an established therapeutic standard can be found in the literature. Therefore, we compared the combination of TIA and CBZ with CLO in two open exploratory studies with matched samples. Outcome parameters were heart rate, blood pressure, complications, withdrawal symptoms (CIWA-Ar scale), and general clinical state (CGI scale). A retrospective evaluation of medical records (30 TIA+CBZ, 30 CLO) was followed by an open prospective study (40 TIA+CBZ, 40 CLO).
4.Chlormethiazole and utilization of vitamin B1 in chronic alcoholics.
Majumdar SK. Eur J Clin Pharmacol. 1980 Oct;18(4):361-2.
Blood vitamin B1 status as reflected by erythrocyte transketolase activation tests has been assessed in 12 chronic alcoholic (M = 8; F = 4; mean age +/- 53.4 +/- 12.9) both before and after treatment with chlormethiazole and parenteral polyvitamins including thiamine hydrochloride. 7 out of 12 patients (58.3%) were found to be deficient before treatment but all returned to normal after treatment. Mean +/- SD, of alpha ETK improved pre-treatment level of 1.174 +/- 0.135 to 1.009 +/- 0.009 after treatment with thiamine. Chlormethiazole did not seem to interfere with the utilization of thiamine. It is therefore concluded, that though structurally related to the thiazole nucleus of thiamine, chlormethiazole, like thiamine antagonists, does not antagonize the effect of the co-enzyme - thiamine pyrophosphate at the receptor sites on the apo-enzyme - transketolase.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related GABA Receptor Products

CAS 128201-89-8 N-ArachidonylGABA

(CAS: 128201-89-8)

N-ArachidonylGABA is first isolated from bovine brain. It was also found to inhibit normal responses to pain in vivo, but has not been fully characterized to da...

CAS 1215833-62-7 DMCM hydrochloride

DMCM hydrochloride
(CAS: 1215833-62-7)

DMCM hydrochloride is a benzodiazepine inverse agonist exhibiting anxiogenic and potent convulsant activity.

CAS 145645-62-1 NNC 711

NNC 711
(CAS: 145645-62-1)

NNC 711 is a GABA uptake inhibitor by GAT-1 with IC50 values of 0.04, 171, 1700 and 622 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1. NNC 711 is an anticonvulsantag...

CAS 233275-76-8 MK 0343

MK 0343
(CAS: 233275-76-8)

MK 0343, also known as MRK-409, is a subtype-selective GABAA partial agonist (Ki values are 0.21, 0.22, 0.23 and 0.40 for α3, α1, α5 and α2 respectively). MK-03...

CAS 156685-94-8 Org 20599

Org 20599
(CAS: 156685-94-8)

Org 20599 is an anaesthetic steroid. It has modulatory effects on GABAA receptors. Org 20599 is a potential theraputic for migraines and headaches.

CAS 164025-44-9 PZ-II-029

(CAS: 164025-44-9)

PZ-II-029,a pyrazoloquinolinone, was reported as the first postitive modulator of GABAA α6β3γ2 subtype functionally selective ligands to date.

CAS 133737-32-3 Pagoclone

(CAS: 133737-32-3)

Pagoclone, an active (+)-enantiomer of the racemate RP 59037, is a ubtype selective partial agonist at GABAA receptor and used for the treatment of panic and an...

CAS 945828-50-2 AA 29504

AA 29504
(CAS: 945828-50-2)

AA 29504 is a positive allosteric modulator of GABAA receptors with anxiolytic activity. It modulates both α4β3δ-containing extrasynaptic receptors and α1β3γ2S-...

CAS 39069-52-8 GS 39783

GS 39783
(CAS: 39069-52-8)

GS 39783 is an allosteric positive modulator of GABAB receptors, decreases cocaine self-administration, blocks the rewarding properties of nicotine and produces...

CAS 157013-85-9 U 89843A

U 89843A
(CAS: 157013-85-9)

U 89843A is a positive allosteric modulator of GABAA receptors. U 89843A potentiates GABA-induced Cl- currents in the α1β2γ2, α3β2γ2 and α6β2γ2 GABAA receptors....

CAS 355022-97-8 TCS 1205

TCS 1205
(CAS: 355022-97-8)

TCS 1205 is a GABAA α2 benzodiazepine receptor agonist and GABAA α1 partial agonist in vitro (Ki = 14 and 121 nM, respectively). It displays non-sedative anxiol...

CAS 374084-31-8 DS2

(CAS: 374084-31-8)

DS2 has been found to be a positive allosteric modulator of δ-GABAA receptors and could probably be useful against analgesics as well as sleep disorders.

Pipequaline HCl

The hydrochloride of pipequaline. Pipequaline is a non-selective GABAA receptor partial agonist that is potentially used as an anxiolytic drug of the nonbenzodi...

CAS 152273-12-6 U-93631

(CAS: 152273-12-6)

U 93631 is a ligand at the picrotoxin site of GABA(A) receptors, allosterically antagonizing GABA-induced Cl- currents. U-93631 causes rapid decay of gamma-amin...

CAS 125464-42-8 Saclofen

(CAS: 125464-42-8)

Saclofen is a selective antagonist at GABAB receptors.

CAS 21715-46-8 Etifoxine

(CAS: 21715-46-8)

Etifoxine, also called as HOE 36801 or Stresam, is a positive allosteric modulator of GABAreceptors that produces anxiolytic effects by preferentially modulatin...

CAS 68547-97-7 Isoguvacine hydrochloride

Isoguvacine hydrochloride
(CAS: 68547-97-7)

Isoguvacine hydrochloride is a selective GABA receptor agonist with anticonvulsant and antiepileptic effect, developed for Neuroscience research.

CAS 371962-01-5 ZAPA sulfate

ZAPA sulfate
(CAS: 371962-01-5)

ZAPA sulfate acts as an agonist at low affinity GABAA receptors and is thus a useful ligand to investigate GABA receptors linked to benzodiazepine receptors. ZA...

CAS 63701-55-3 Arbaclofen Hydrochloride

Arbaclofen Hydrochloride
(CAS: 63701-55-3)

Arbaclofen, the R-enantiomer of baclofen, is a selective gamma-amino butyric acid type B receptor agonist used for autism spectrum disorder and fragile X syndro...

CAS 485-49-4 (+)-Bicuculline

(CAS: 485-49-4)

(+)-Bicuculline is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels.

Chemical Structure

CAS 6001-74-7 Chlormethiazole hydrochloride

Quick Inquiry

Verification code

Featured Items