Chlormethiazole hydrochloride - CAS 6001-74-7
Category: Inhibitor
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GABA Receptor
Chlormethiazole hydrochloride is the hydrochloride salt of chlormethiazole, which is a GABAA agonist. It is a useful research chemical and is used in the study of effects of thiazole methiodide and hydrochloride fractions of thiamine upon the neuromuscular system. It is neuroprotective in a number of animal models and is used as a sedative and anticonvulsant. It prevents the degeneration of serotonergic nerve terminals induced by MDMA.
≥99% by HPLC
4-methyl-5-(β-chloroethyl)thiazole hydrochloride; 5-(2-Chloroethyl)-4-methylthiazole hydrochloride; Somnevrin hydrochloride
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1.Alcohol withdrawal treatment in intoxicated vs non-intoxicated patients: a controlled open-label study with tiapride/carbamazepine, clomethiazole and diazepam.
Lucht M1, Kuehn KU, Armbruster J, Abraham G, Gaensicke M, Barnow S, Tretzel H, Freyberger HJ. Alcohol Alcohol. 2003 Mar-Apr;38(2):168-75.
AIMS AND METHODS: Alcohol withdrawal treatment efficacy of tiapride/carbamazepine (A) vs clomethiazole (B) vs diazepam (C) in non-intoxicated patients and vs tiapride/carbamazepine in intoxicated patients (D; breath alcohol concentration > or = 1 g/l) was tested (n = 127) in a controlled randomized open-label study.
2.Oxcarbazepine in combination with Tiaprid in inpatient alcohol-withdrawal--a RCT.
Croissant B1, Loeber S, Diehl A, Nakovics H, Wagner F, Kiefer F, Mann K. Pharmacopsychiatry. 2009 Sep;42(5):175-81. doi: 10.1055/s-0029-1202264. Epub 2009 Sep 1.
INTRODUCTION: Oxcarbazepine (OXC), a derivative of Carbamazepine (CBZ), may represent a solution to metabolic and side effects of CBZ treatment due to the fact that renal excretion is its major route of elimination. The goal of the study is to compare the efficacy and tolerability of OXC/Tiaprid (TIA) combination therapy to the well established Clomethiazole (CLO) therapy in an inpatient setting.
3.Treatment of alcohol withdrawal: tiapride and carbamazepine versus clomethiazole. A pilot study.
Franz M1, Dlabal H, Kunz S, Ulferts J, Gruppe H, Gallhofer B. Eur Arch Psychiatry Clin Neurosci. 2001 Aug;251(4):185-92.
In Germany, clomethiazole (CLO) and benzodiazepines are predominantly used as therapeutic agents in the treatment of the alcohol withdrawal syndrome (AWS). These agents have disadvantages such as sedation, risk of respiratory insufficiency, and cardiovascular complications as well as addictive potential. Alternatively, it could be demonstrated that both tiapride (TIA) and carbamazepine (CBZ) are efficient in the treatment of AWS with less toxicity. However, they seem to be less effective in AWS than CLO as single agents. But no systematic comparison of the combination of TIA and CBZ against an established therapeutic standard can be found in the literature. Therefore, we compared the combination of TIA and CBZ with CLO in two open exploratory studies with matched samples. Outcome parameters were heart rate, blood pressure, complications, withdrawal symptoms (CIWA-Ar scale), and general clinical state (CGI scale). A retrospective evaluation of medical records (30 TIA+CBZ, 30 CLO) was followed by an open prospective study (40 TIA+CBZ, 40 CLO).
4.Chlormethiazole and utilization of vitamin B1 in chronic alcoholics.
Majumdar SK. Eur J Clin Pharmacol. 1980 Oct;18(4):361-2.
Blood vitamin B1 status as reflected by erythrocyte transketolase activation tests has been assessed in 12 chronic alcoholic (M = 8; F = 4; mean age +/- 53.4 +/- 12.9) both before and after treatment with chlormethiazole and parenteral polyvitamins including thiamine hydrochloride. 7 out of 12 patients (58.3%) were found to be deficient before treatment but all returned to normal after treatment. Mean +/- SD, of alpha ETK improved pre-treatment level of 1.174 +/- 0.135 to 1.009 +/- 0.009 after treatment with thiamine. Chlormethiazole did not seem to interfere with the utilization of thiamine. It is therefore concluded, that though structurally related to the thiazole nucleus of thiamine, chlormethiazole, like thiamine antagonists, does not antagonize the effect of the co-enzyme - thiamine pyrophosphate at the receptor sites on the apo-enzyme - transketolase.
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CAS 6001-74-7 Chlormethiazole hydrochloride

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