Chlorhexidine digluconate - CAS 18472-51-0
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Not Intended for Therapeutic Use. For research use only.
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Chlorhexidine has been used to study how essential oils improve skin antisepsis when combined with chlorhexidine digluconate and is used for skin permeation studies . Chronic rinsing with chlorhexidine has been shown to decrease the saltiness of NaCl and the bitterness of quinine.
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1. Development of resistance of mutans streptococci and Porphyromonas gingivalis to chlorhexidine digluconate and amine fluoride/stannous fluoride-containing mouthrinses, in vitro
Eva M. Kulik & Tuomas Waltimo & Roland Weiger & Irene Schweizer & Krystyna Lenkeit. Clin Oral Invest (2015) 19:1547–1553
Chlorhexidine digluconate (CHX), a cationic biguanide was introduced as an antimicrobial agent in 1954. Because of its broad antimicrobial spectrumand high substantivity, this antiseptic is considered the “gold standard” for the control of plaque and gingivitis. However, adverse effects, including taste disturbance, tooth staining and/or irritation of the oral mucosa, and a recently suggested possible increase in blood pressure, hamper its recommendation for long-term oral use. The development of antibiotic resistance is a substantial cause for concern. Oralmouthrinses with nonselective disinfecting effect may reduce the need of systemic antibiotics, at least in severely ill medically compromised hosts. However, chlorhexidine-resistant bacterial strains, including Proteus and Klebsiella species, as well as CHX-associated changes in the bacterial cell functions have already been described. The emergence of resistance has not beenwell documented in bacteria associated with common oral diseases, including periodontitis and caries.
2. Release of chlorhexidine digluconate and flexural properties of glass fibre reinforced provisional fixed partial denture polymer
Chlorhexidine digluconate (CHX) has been widely used in clinical dentistry. It is an effective disinfectant in direct exposure and in addition has an ability to adhere to various substrates resulting in a long-termwidespectrum antimicrobial efficacy. Chlorhexidine digluconate (CHX) confounds also microbial adhesion to polymer surfaces. Earlier in vitro studies have shown that number of adherent of yeast cell decreases when the denture base polymer has incubated with Chlorhexidine digluconate (CHX). It has previously been shown that pretreating the porous polymer preimpregnated glass fibre reinforcement with CHX results in reduction in the number of adherent yeast cells on the surface FRC material. However, to our knowledge there is no information available concerning the influence of CHX to mechanical properties of fiber-reinforced composites. Furthermore, release rate of CHX from such material is not known. The aimof this study was to determine flexural properties of provisional FPD polymer that had been reinforced with glass fibre reinforcement laced with Chlorhexidine digluconate (CHX). In addition, release of Chlorhexidine digluconate (CHX) from the fibre reinforced test specimen into water was determined during 180 days water storage.
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CAS 18472-51-0 Chlorhexidine digluconate

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