Chloramphenicol - CAS 56-75-7
Catalog number:
56-75-7
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C11H12Cl2N2O5
Molecular Weight:
323.13
COA:
Inquire
Targets:
Antibacterial
Description:
Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
Chloromycetin
MSDS:
Inquire
1.Green synthesized gold nanoparticles decorated graphene oxide for sensitive determination of chloramphenicol in milk, powdered milk, honey and eye drops.
Karthik R1, Govindasamy M1, Chen SM2, Mani V3, Lou BS4, Devasenathipathy R5, Hou YS1, Elangovan A6. J Colloid Interface Sci. 2016 Apr 27;475:46-56. doi: 10.1016/j.jcis.2016.04.044. [Epub ahead of print]
A simple and rapid green synthesis using Bischofia javanica Blume leaves as reducing agent was developed for the preparation of gold nanoparticles (AuNPs). AuNPs decorated graphene oxide (AuNPs/GO) was prepared and employed for the sensitive amperometric determination of chloramphenicol. The green biosynthesis requires less than 40s to reduce gold salts to AuNPs. The formations of AuNPs and AuNPs/GO were evaluated by scanning electron and atomic force microscopies, UV-Visible and energy dispersive X-ray spectroscopies, X-ray diffraction studies, and electrochemical methods. AuNPs/GO composite film modified electrode was fabricated and shown excellent electrocatalytic ability towards chloramphenicol. Under optimal conditions, the amperometric sensing platform has delivered wide linear range of 1.5-2.95μM, low detection limit of 0.25μM and high sensitivity of 3.81μAμM-1cm-2. The developed sensor exhibited good repeatability and reproducibility, anti-interference ability and long-term storage stability.
2.Polyamino-Isoprenic Derivatives Block Intrinsic Resistance of P. aeruginosa to Doxycycline and Chloramphenicol In Vitro.
Borselli D1, Lieutaud A1, Thefenne H1,2, Garnotel E1,2, Pagès JM1, Brunel JM3, Bolla JM1. PLoS One. 2016 May 6;11(5):e0154490. doi: 10.1371/journal.pone.0154490. eCollection 2016.
Multidrug resistant bacteria have been a worldwide concern for decades. Though new molecules that effectively target Gram-positive bacteria are currently appearing on the market, a gap remains in the treatment of infections caused by Gram-negative bacteria. Therefore, new strategies must be developed against these pathogens. The aim of this study was to select an antibiotic for which a bacterium is naturally resistant and to use an escort molecule to restore susceptibility, similarly to the model of β-lactam/ β-lactamase inhibitors. High-content screening was performed on the reference strain PA01, allowing the selection of four polyamino-isoprenic compounds that acted synergistically with doxycycline. They were assayed against clinical isolates and Multi-Drug-Resistant strains. One of these compounds was able to decrease the MIC of doxycycline on the reference strain, efflux pump overproducers and clinical isolates of P. aeruginosa, to the susceptibility level.
3.Determination of chloramphenicol, thiamphenicol, florfenicol and florfenicol amine in poultry, swine, bovine and fish by liquid chromatography-tandem mass spectrometry.
Barreto F1, Ribeiro C2, Barcellos Hoff R3, Dalla Costa T4. J Chromatogr A. 2016 Apr 16. pii: S0021-9673(16)30430-7. doi: 10.1016/j.chroma.2016.04.024. [Epub ahead of print]
A simple, rapid and sensitive method for confirmatory and quantitative purposes using liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) was developed and validated for determination of chloramphenicol, thiamphenicol, florfenicol and its metabolite, florfenicol amine, in poultry, swine, bovine and fish muscle. Sample preparation was based on extraction with organic solvent (ethyl acetate: ammonium hydroxide, 98:2) followed by evaporation and fat removal using hexane. The chromatographic separation was carried out with an XTerra C18 column with a gradient elution using water and acetonitrile both with 2mM of ammonium acetate. Mass spectrometry with electrospray ionization was operated in positive or negative polarity using selected-reaction monitoring (SRM) analysis mode, achieving the requirements of four identification points for each compound. Chloramphenicol-D5 was added as internal standard. Method validation was performed according to the criteria of Commission Decision 2002/657/EC.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Antibacterial Products


CAS 69-52-3 Ampicillin sodium

Ampicillin sodium
(CAS: 69-52-3)

Ampicillin is a beta-lactam antibiotic that is part of the aminopenicillin family.

CAS 148717-90-2 Squalamine

Squalamine
(CAS: 148717-90-2)

Squalamine is a naturally derived broad-spectrum antibiotic that is predominantly derived from the livers of dogfish and other shark species. Squalamine is unde...

CAS 72-80-0 Chlorquinaldol

Chlorquinaldol
(CAS: 72-80-0)

Chlorquinaldol is an antimicrobial agent.

CAS 79-57-2 Oxytetracycline

Oxytetracycline
(CAS: 79-57-2)

Oxytetracycline (Terramycin) was the second of the broad-spectrum tetracycline group of antibiotics to be discovered.

CAS 104010-37-9 Ceftiofur Sodium

Ceftiofur Sodium
(CAS: 104010-37-9)

Ceftiofur sodium, one of the third generation antibiotics, is a cephalosporin based antibacterial compound that has been approved to be used in veterinary medic...

CAS 80-08-0 Dapsone

Dapsone
(CAS: 80-08-0)

Dapsone is a sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae, which has anti-inflammatory and i...

CAS 61036-62-2 Teicoplanin

Teicoplanin
(CAS: 61036-62-2)

Teicoplanin is an antibiotic used in the prophylaxis and treatment of serious infections. Teicoplanin is a semisynthetic glycopeptide antibiotic with a spectrum...

CAS 127-56-0 Sulfacetamide Sodium

Sulfacetamide Sodium
(CAS: 127-56-0)

Sulfacetamide Sodium is an anti-biotic.

CAS 1393-48-2 Thiostrepton

Thiostrepton
(CAS: 1393-48-2)

Thiostrepton, a kind of natural peptide thiazole antibiotic, has been found to be effective in restraining the protein synthesis and could also influence the ce...

CAS 68-41-7 D-Cycloserine

D-Cycloserine
(CAS: 68-41-7)

D-Cycloserine is an analog of the amino acid D-alanine.it Inhibits cell wall biosynthesis (D-Ala peptide bond formation) and Also prevents conversion of D-Ala t...

Ornidazole Levo-
(CAS: 166734-83-4)

Ornidazole Levo-, the levo-isomer of Ornidazole, with good tolerance, and good in vivo distribution, it can be used to prepare anti-anaerobic bacteria infection...

CAS 124858-35-1 Nadifloxacin

Nadifloxacin
(CAS: 124858-35-1)

Nadifloxacin is a potent, broad-spectrum, quinolone agent approved for topical use in acne vulgaris and skin infections.

CAS 39831-55-5 Amikacin disulfate

Amikacin disulfate
(CAS: 39831-55-5)

Amikacin sulfate binds to 16S rRNA (bacterial 30S ribosome), causing misreading of mRNA and supressing proteins synthesis.

CAS 4800-94-6 Carbenicillin disodium

Carbenicillin disodium
(CAS: 4800-94-6)

Carbenicillin is a semi-synthetic penicillin antibiotic which interferes with cell wall synthesis of gram-negative bacteria while displaying low toxicity. The c...

CHIR-090
(CAS: 728865-23-4)

CHIR-090 is a very potent and tight-binding inhibitor of LpxC, which is a zinc-dependent amidase and present in almost all Gram-negative bacteria, and is a prom...

CAS 121577-32-0 Gatifloxacin hydrochloride

Gatifloxacin hydrochloride
(CAS: 121577-32-0)

Gatifloxacin (hydrochloride) is an antibiotic of the fourth-generation fluoroquinolone family, it inhibits the bacterial enzymes DNA gyrase and topoisomerase IV...

CAS 57018-04-9 Tolclofos-Methyl

Tolclofos-Methyl
(CAS: 57018-04-9)

Tolclofos-methyl is a broad-spectrum aromatic hydrocarbon fungicide as an excellent foundation seed fungicide.

CAS 89786-04-9 Tazobactam acid

Tazobactam acid
(CAS: 89786-04-9)

Tazobactam acid is a pharmaceutical drug that inhibits the action of bacterial β-lactamases, especially those belonging to the SHV-1 and TEM groups. It is commo...

CAS 1070-11-7 Ethambutol HCl

Ethambutol HCl
(CAS: 1070-11-7)

Ethambutol is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases.

CAS 85721-33-1 Ciprofloxacin

Ciprofloxacin
(CAS: 85721-33-1)

Ciprofloxacin is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM.

Chemical Structure

CAS 56-75-7 Chloramphenicol

Quick Inquiry

Verification code

Featured Items