Chloramine-T - CAS 127-65-1
Catalog number:
127-65-1
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C7H7ClNNaO2S.3(H2O)
Molecular Weight:
281.69
COA:
Inquire
Targets:
Others
Description:
Chloramine-T could be commonly used as decolorizer, sanitizer and detergent in sorts of chemical areas.
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Purity:
95%
Appearance:
white or yellow powder with a chlorine-like odour
Synonyms:
Chloramine-T; CHLORAMINE T; Chlorozone; Chloraseptine; Chloralone
Solubility:
H2O: > 41 mg/mL
Storage:
2-8ºC
MSDS:
Inquire
Application:
Chloramine-T could be commonly used as decolorizer, sanitizer and detergent in sorts of chemical areas.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
Boiling Point:
314.3ºC at 760mmHg
Melting Point:
167-170ºC(lit.)
Density:
1.36g/cm3
InChIKey:
VDQQXEISLMTGAB-UHFFFAOYSA-N
InChI:
InChI=1S/C7H7ClNO2S.Na/c1-6-2-4-7(5-3-6)12(10,11)9-8;/h2-5H,1H3;/q-1;+1
Canonical SMILES:
CC1=CC=C(C=C1)S(=O)(=O)[N-]Cl.[Na+]
1.INTERACTION OF CAMPTOTHECIN WITH HUMAN SERUM ALBUMIN DETERMINED BY FLUORESCENCE ANISOTROPY SPECTROSCOPY.
Wybranowski T, Ziomkowska B, Cyrankiewicz M, Kruszewski S. Acta Pol Pharm. 2016 Jan-Feb;73(1):29-34.
The study can be useful for understanding the interaction of camptothecin with human serum albu- min. There are two forms of camptothecin (the carboxylate form (CPT-C) and the lactone form (CPT-L)) but only the lactone one is pharmacologically active. It was reported earlier that in the presence of HSA, the active lactone form of camptothecin changes to inactive carboxylate form and it reduces the antitumor activities of camptothecin. However, those studies were performed at physiological pH (7.4) and with non-oxidized and non-glycosylated albumin. The aim of this study was to investigate the effect of oxidative stress, glycosylation, pH changes and competitor drugs on inactivation of lactone form of camptothecin in albumin solution using measurements of fluorescence anisotropy spectroscopy. It was tried to prove that in vivo camptothecin may be present in higher amount in lactone form than previously thought. Due to a reduction of pH value, a decreased rate of hydrolysis from CPT-L to CPT-C was observed.
2.Enhanced tumor retention of radioiodinated anti-epidermal growth factor receptor antibody using novel bifunctional iodination linker for radioimmunotherapy.
Kim EJ1, Kim BS1, Choi DB1, Chi SG2, Choi TH3. Oncol Rep. 2016 Mar 24. doi: 10.3892/or.2016.4706. [Epub ahead of print]
Radioimmunotherapy (RIT) uses an antibody labeled with a radionuclide to deliver cytotoxic radiation to a target tumor cells. Radioiodine is most commonly employed to prepare radiolabeled proteins (antibodies, peptides) for in vitro and in vivo applications. A major shortcoming of radioiodinated proteins prepared by direct labeling methods is their deiodination in vivo. For the preparation of more stable radioiodinated antibodies, we developed a new linker (N-(4-isothiocyanatobenzyl)-2-(3-(tributylstannyl)phenyl) acetamide (IBPA). This study evaluated the usefulness of IBPA as a linker for the stable radioiodinated internalizing antibody, cetuximab. Directly labeled cetuximab ([125I]-cetuximab) was prepared by the chloramine T method. To prepare indirectly labeled cetuximab using IBPA ([125I]-IBPA-cetuximab), IBPA was radioiodinated using chloramine-T to give N-(4-isothiocyanatobenzyl)-2-(3-[125I]phenyl)acetamide ([125I]‑IBPA), which was purified by high performance liquid chromatography.
3.Two Fatal Intoxications with Cyanohydrins.
Zheng S1, Yuan X2, Wang W1, Liang C1, Cao F1, Zhang R1. J Anal Toxicol. 2016 Mar 29. pii: bkw023. [Epub ahead of print]
Cyanohydrins, also be called cyanoalcohols, are important industrial precursors to carboxylic acids and some amino acids. Acetone cyanohydrin (ACH) and formaldehyde cyanohydrin (glycolonitrile, FCH), which are the typical examples of cyanohydrins, are classified as extremely hazardous substances. As the cyanohydrins can readily decompose, and it is hard to find cyanohydrins in gastric contents and heart blood, the determination study in biological samples can be divided into two parts: the first is the determination of HCN by using a Prussian blue reaction and the HS-GC-MSD after derivatization by chloramine-T. The second is the determination of acetone or formaldehyde. In this part, headspace gas chromatography with flame ionization detector (HS-GC-FID) and solid phase microextraction (SPME)-gas chromatography with mass spectrometric detectors (GC-MSD) had been used. In this report, we reported two fatal intoxication cases of ACH and FCH; one person was killed by his wife by poisoning his food and the other was suicide by poison.
4.SPECT of Transplanted Islets of Langerhans by Dopamine 2 Receptor Targeting in a Rat Model.
Willekens SM1, van der Kroon I1, Joosten L1, Frielink C1, Boerman OC1, van den Broek SA2, Brom M1, Gotthardt M1. Mol Pharm. 2016 Jan 4;13(1):85-91. doi: 10.1021/acs.molpharmaceut.5b00518. Epub 2015 Dec 4.
Pancreatic islet transplantation can be a more permanent treatment for type 1 diabetes compared to daily insulin administration. Quantitative and longitudinal noninvasive imaging of viable transplanted islets might help to further improve this novel therapy. Since islets express dopamine 2 (D2) receptors, they could be visualized by targeting this receptor. Therefore, the D2 receptor antagonist based tracer [(125/123)I][IBZM] was selected to visualize transplanted islets in a rat model. BZM was radioiodinated, and the labeling was optimized for position 3 of the aromatic ring. [(125)I]-3-IBZM was characterized in vitro using INS-1 cells and isolated islets. Subsequently, 1,000 islets were transplanted in the calf muscle of WAG/Rij rats and SPECT/CT images were acquired 6 weeks after transplantation. Finally, the graft containing muscle was dissected and analyzed immunohistochemically. Oxidative radioiodination resulted in 3 IBZM isomers with different receptor affinities.
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Chemical Structure

CAS 127-65-1 Chloramine-T

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