Chlophedianol hydrochloride - CAS 511-13-7
Catalog number: B0084-093359
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C17H20ClNO.HCl
Molecular Weight:
326.26
COA:
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Description:
Chlophedianol hydrochloride is a centrally-acting cough suppressant. It is used in the treatment of dry cough. It has local anesthetic and antihistamine properties, and may have anticholinergic effects at high doses. It has been listed.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-093359 100 mg $198 In stock
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Brife Description:
cough suppressant, dry cough
Purity:
95%
Appearance:
White Solid
Synonyms:
Chlophedianol HCl;Coldrin;Detigon;Pectolitan;Refugal;2-Chloro-alpha-(2-dimethylaminoethyl)benzhydrol;Baltix;1-(2-Chlorophenyl)-3-(dimethylamino)-1-phenylpropan-1-ol hydrochloride;1-o-Chlorophenyl-1-phenyl-3-dimethylamino-1-propanolhydrochloride;2-Chloro-[
Solubility:
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Storage:
Hygroscopic, Refrigerator, under inert atmosphere
MSDS:
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Application:
Chlophedianol hydrochloride is used in the treatment of dry cough.
Quantity:
Grams to Kilograms
Boiling Point:
429.8ºC at 760mmHg
Melting Point:
190-191 °C
InChIKey:
XYGSFNHCFFAJPO-UHFFFAOYSA-N
InChI:
InChI=1S/C17H20ClNO.ClH/c1-19(2)13-12-17(20,14-8-4-3-5-9-14)15-10-6-7-11-16(15)18;/h3-11,20H,12-13H2,1-2H3;1H
Canonical SMILES:
CN(C)CCC(C1=CC=CC=C1)(C2=CC=CC=C2Cl)O.Cl
Current Developer:
Chlophedianol hydrochloride has been listed.
1.Chlophedianol Hydrochloride: A New Antitussive Agent.
Boyd EM, Boyd CE. Can Med Assoc J. 1960 Dec 17;83(25):1298-301.
2.High performance liquid chromatographic determination of chlophedianol hydrochloride in "jung fei", a complex tablet formulation.
Burrows GW, Evertts VL. J Chromatogr Sci. 1985 Jan;23(1):37-8.
A high performance liquid chromatographic method is presented for the determination of chlophedianol hydrochloride in a complex tablet formulation. Tablets are dissolved in a water/acetonitrile (50/50) mixture. Samples are separated on an octadecylsilane column with a mobile phase of 70% acetonitrile and 30% aqueous solution of 0.005M 1-octanesulfonic acid, 1% acetic acid, and 1% diethylamine. Effluent is monitored by a spectrophotometric detector with a 254-nm filter. Chlophedianol is separated from a complex mixture of plant extracts and fillers in the tablets.
3.A comparative randomized double-blind clinical trial of isoaminile citrate and chlophedianol hydrochloride as antitussive agents.
Diwan J, Dhand R, Jindal SK, Malik SK, Sharma PL. Int J Clin Pharmacol Ther Toxicol. 1982 Aug;20(8):373-5.
The efficacy and safety of a new centrally acting antitussive agent, isoaminile citrate, was compared with that of chlophedianol hydrochloride in a double-blind, randomized interpatient study. A total of 66 patients participated, two and four patients were lost to follow-up with isoaminile and chlophedianol, respectively. In the experimentally induced cough in 12 normal human subjects, isoaminile (40 mg) was as effective as chlophedianol (20 mg), but its duration of action was somewhat longer. One subject developed allergic skin rash with chlophedianol and was withdrawn from the study. In 60 patients with cough associated with chest diseases, isoaminile (40 mg, 3 x daily) was as effective as chlophedianol (20 mg, 3 x daily) in suppressing cough as judged from the 3-h and 24-h cough counts. The increase in PEFR at day 7 of treatment was somewhat more marked with chlophedianol as compared with isoaminile. None of the drugs interfered with the expectoration process.
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CAS 511-13-7 Chlophedianol hydrochloride

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