CHIR-99021 - CAS 252917-06-9
Catalog number:
B0084-462893
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C22H18Cl2N8.HCl
Molecular Weight:
501.8
COA:
Inquire
Targets:
GSK-3
Description:
CHIR-99021 (CT99021) is a glycogen synthase kinase 3β (GSK3β) inhibitor that has antiproliferative activity in vitro and in vivo. CHIR-99021 inhibits GSK-3 with IC50 at 7 nM. In a series of carcinoma cell lines, the IC50 of CHIR99021 for proliferation is about 10μM.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-462893 100 mg $398 In stock
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Brife Description:
glycogen synthase kinase 3β (GSK3β) inhibitor, antiproliferative activity
Purity:
>98%
Related CAS:
1782235-14-6 (3HCl); 2109414-84-6 (2HCl); 1797989-42-4 (HCl)
Appearance:
Solid powder
Synonyms:
6-((2-((4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile; CHIR99021; CHIR-99021; CHIR 99021; CT99021; CT-99021; CT 99021
MSDS:
Inquire
Application:
potential antineoplastic agent
InChIKey:
AQGNHMOJWBZFQQ-UHFFFAOYSA-N
InChI:
1S/C22H18Cl2N8/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19/h2-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32)
Canonical SMILES:
N#CC1=CN=C(NCCNC2=NC=C(C3=NC(C)=CN3)C(C4=CC=C(Cl)C=C4Cl)=N2)C=C1
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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