Chikusetsu saponin IVa - CAS 51415-02-2
Catalog number:
51415-02-2
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C42H66O14
Molecular Weight:
794.97
COA:
Inquire
Targets:
AMPK
Description:
Chikusetsusaponin IVa is a novel AMPK activator could be useful for the treatment of T2DM or other metabolic disorders.
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Purity:
≥98%
Appearance:
White powder
Synonyms:
Chikusetsu saponin Iva; Beta-D-Glucopyranosiduronic acid, (3beta)-28-(beta-D-glucopyranosyloxy)-28-oxoolean-12-en-3-yl;
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
Antiarrhythmic
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
InChIKey:
YOSRLTNUOCHBEA-SGVKAIFKSA-N
InChI:
1S/C42H66O14/c1-37(2)14-16-42(36(52)56-34-30(48)27(45)26(44)22(19-43)53-34)17-15-40(6)20(21(42)18-37)8-9-24-39(5)12-11-25(38(3,4)23(39)10-13-41(24,40)7)54-35-31(49)28(46)29(47)32(55-35)33(50)51/h8,21-32,34-35,43-49H,9-19H2,1-7H3,(H,50,51)/t21-,22+,23-,24+
Canonical SMILES:
CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)C)OC6C(C(C(C(O6)C(=O)O)O)O)O)C)C)C2C1)C)C(=O)OC7C(C(C(C(O7)CO)O)O)O)C
1.[Influence of soil factors on quality of panacis majoris rhizoma].
Yang XJ, Xu MM, Song B, Liu C, Cui JC, Wang W, Song XM. Zhong Yao Cai. 2014 Sep;37(9):1513-7.
OBJECTIVE: To research and screen the soil factors which influenced the quality of Panacis Majoris Rhizoma.
2.Development of a method to screen and isolate potential α-glucosidase inhibitors from Panax japonicus C.A. Meyer by ultrafiltration, liquid chromatography, and counter-current chromatography.
Li S1, Tang Y1, Liu C1, Zhang Y1. J Sep Sci. 2015 Jun;38(12):2014-23. doi: 10.1002/jssc.201500064. Epub 2015 May 13.
A new assay based on ultrafiltration, liquid chromatography and mass spectrometry was developed for the rapid screening and identification of the ligands for α-glucosidase from the extract of Panax japonicus. Six saponins were identified as α-glucosidase inhibitors. Subsequently, the specific binding ligands, namely, notoginsenoside R1 , ginsenoside Rb1 , chikusetsusaponin V, chikusetsusaponin IV, chikusetsusaponin IVa, and ginsenoside Rd (the purities were 94.18, 95.43, 96.09, 93.26, 94.50, 93.86%, respectively) were separated by counter-current chromatography using two-phase solvent systems composed of tert-butyl methyl ether, acetonitrile, 0.1% aqueous formic acid (3.8:1.0:4.4, v/v/v) and the solvent system composed of methylene chloride, isopropanol, methanol, 0.1% aqueous formic acid (5.8:1.0:6.0:2.2, v/v/v). The results demonstrate that ultrafiltration, liquid chromatography and mass spectrometry combined with high-speed counter-current chromatography might provide not only a powerful tool for screening and isolating α-glucosidase inhibitors in complex samples but also a useful platform for discovering bioactive compounds for the prevention and treatment of diabetes mellitus.
3.Insulinotropic effect of Chikusetsu saponin IVa in diabetic rats and pancreatic β-cells.
Cui J1, Xi MM1, Li YW1, Duan JL1, Wang L1, Weng Y1, Jia N1, Cao SS1, Li RL1, Wang C1, Zhao C1, Wu Y2, Wen AD3. J Ethnopharmacol. 2015 Apr 22;164:334-9. doi: 10.1016/j.jep.2015.02.032. Epub 2015 Feb 19.
ETHNOPHARMACOLOGICAL RELEVANCE: As a well-known traditional Chinese medicine the root bark of Aralia taibaiensis has traditionally been used as the medicine considered alleviating several disorders including diabetes mellitus (DM). Chikusetsu saponin IVa (CHS) has been defined as a major active ingredient of triterpenoid saponins extracted from Aralia taibaiensis. The scientific evidence of anti-diabetic effect for CHS remains unknown and the purpose of our study was to study its hypoglycemic and insulin secretagogue activities.
4.Antithrombotic effect of chikusetsusaponin IVa isolated from Ilex paraguariensis (Maté).
Dahmer T1, Berger M, Barlette AG, Reck J Jr, Segalin J, Verza S, Ortega GG, Gnoatto SC, Guimarães JA, Verli H, Gosmann G. J Med Food. 2012 Dec;15(12):1073-80. doi: 10.1089/jmf.2011.0320. Epub 2012 Nov 7.
The triterpene chikusetsusaponin IVa was isolated from the fruit of Ilex paraguariensis. Using biochemical and pharmacological methods, we demonstrated that chikusetsusaponin IVa (1) prolongs the recalcification time, prothrombin time, activated partial thromboplastin time, and thrombin time of normal human plasma in a dose-dependent manner, (2) inhibits the amidolytic activity of thrombin and factor Xa upon synthetic substrates S2238 and S2222, (3) inhibits thrombin-induced fibrinogen clotting (50% inhibition concentration, 199.4 ± 9.1 μM), and (4) inhibits thrombin- and collagen-induced platelet aggregation. The results also indicate that chikusetsusaponin IVa preferentially inhibits thrombin in a competitive manner (K(i)=219.6 μM). Furthermore, when administered intravenously to rats, chikusetsusaponin IVa inhibited thrombus formation in a stasis model of venous thrombosis, although it did not induce a significant bleeding effect. Chikusetsusaponin IVa also prolonged the ex vivo activated partial thromboplastin time.
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CAS 51415-02-2 Chikusetsu saponin IVa

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