Chicoric acid - CAS 6537-80-0
Catalog number:
6537-80-0
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C22H18O12
Molecular Weight:
474.37
COA:
Inquire
Targets:
Others
Description:
Chicoric Acid, a natural product, is reported to be antioxidative, is an effective inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tissues.
Publictions citing BOC Sciences Products
  • >> More
Purity:
≥98%
Appearance:
Pale Yellow Solid
Synonyms:
Cichoric Acid; (2R,3R)-2,3-bis[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]butanedioic acid;
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
Antiviral
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
Melting Point:
>193°C (dec.)
InChIKey:
YDDGKXBLOXEEMN-IABMMNSOSA-N
InChI:
1S/C22H18O12/c23-13-5-1-11(9-15(13)25)3-7-17(27)33-19(21(29)30)20(22(31)32)34-18(28)8-4-12-2-6-14(24)16(26)10-12/h1-10,19-20,23-26H,(H,29,30)(H,31,32)/b7-3+,8-4+/t19-,20-/m1/s1
Canonical SMILES:
C1=CC(=C(C=C1C=CC(=O)OC(C(C(=O)O)OC(=O)C=CC2=CC(=C(C=C2)O)O)C(=O)O)O)O
1.Chicoric acid binds to two sites and decreases the activity of the YopH bacterial virulence factor.
Kuban-Jankowska A1, Sahu KK2, Gorska M1, Tuszynski JA2,3, Wozniak M1. Oncotarget. 2016 Jan 19;7(3):2229-38. doi: 10.18632/oncotarget.6812.
Chicoric acid (CA) is a phenolic compound present in dietary supplements with a large spectrum of biological properties reported ranging from antioxidant, to antiviral, to immunostimulatory properties. Due to the fact that chicoric acid promotes phagocytic activity and was reported as an allosteric inhibitor of the PTP1B phosphatase, we examined the effect of CA on YopH phosphatase from pathogenic bacteria, which block phagocytic processes of a host cell. We performed computational studies of chicoric acid binding to YopH as well as validation experiments with recombinant enzymes. In addition, we performed similar studies for caffeic and chlorogenic acids to compare the results. Docking experiments demonstrated that, from the tested compounds, only CA binds to both catalytic and secondary binding sites of YopH. Our experimental results showed that CA reduces activity of recombinant YopH phosphatase from Yersinia enterocolitica and human CD45 phosphatase.
2.Effect of Chicoric Acid on Mast Cell-Mediated Allergic Inflammation in Vitro and in Vivo.
Lee NY1,2, Chung KS1, Jin JS2, Bang KS, Eom YJ3, Hong CH3, Nugroho A4, Park HJ5, An HJ1. J Nat Prod. 2015 Dec 24;78(12):2956-62. doi: 10.1021/acs.jnatprod.5b00668. Epub 2015 Nov 23.
Chicoric acid (dicaffeoyl-tartaric acid), is a natural phenolic compound found in a number of plants, such as chicory (Cichorium intybus) and Echinacea (Echinacea purpurea), which possesses antioxidant, anti-inflammatory, antiviral, and analgesic activities. Although these biological effects of chicoric acid have been investigated, there are no reports of its antiallergic-related anti-inflammatory effects in human mast cells (HMC)-1 or anaphylactic activity in a mouse model. Therefore, we investigated the antiallergic-related anti-inflammatory effect of chicoric acid and its underlying mechanisms of action using phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated HMC-1 cells. Chicoric acid decreased the mRNA expression of pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β. We studied the inhibitory effects of chicoric acid on the nuclear translocation of nuclear factor kappa B (NF-κB) and activation of caspase-1.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 865479-71-6 5-R-Rivaroxaban

5-R-Rivaroxaban
(CAS: 865479-71-6)

5-R-Rivaroxaban is the R-isomer of Rivaroxaban, which is a novel, oral, direct Factor Xa (FXa) inhibitor. It is useful for antithrombotic agent and is a promisi...

CAS 127-48-0 Trimethadione

Trimethadione
(CAS: 127-48-0)

Trimethadione, an oxazolidinedione derivative, is an anticonvulsant commonly used in the treatment of epilepsy.

CAS 25046-79-1 Glisoxepide

Glisoxepide
(CAS: 25046-79-1)

Glisoxepide, a second-generation sulfonylurea, exerts greater binding affinity than the first-generation compounds. With antihyperglycemic activity, Glisoxepide...

CAS 60-56-0 Methimazole

Methimazole
(CAS: 60-56-0)

Methimazole (also known as Tapazole or Thiamazole or MMI) is an antithyroid drug,and part of the thioamide group. Like its counterpart propylthiouracil, a major...

CAS 22457-89-2 Benfotiamine

Benfotiamine
(CAS: 22457-89-2)

Benfotiamine is an amphiphilic S-acyl thiamine derivative used as a lipid soluble alternative source of bioavailable thiamine. Benfotiamine is being investigate...

CAS 498-02-2 Apocynin

Apocynin
(CAS: 498-02-2)

Apocynin, also known as acetovanillone, is a natural organic compound structurally related to vanillin. It has been isolated from a variety of plant sources and...

JNJ-10329670
(CAS: 400797-24-2)

JNJ-10329670 represents a novel class of immunosuppressive compounds with a highly potent (Ki ~30 nM)

PD-116152
(CAS: 101708-64-9)

PD-116152 is a novel and highly substituted phenazine. It has antitumor activity. It was isolated from the culture broth of a Streptomyces sp.

CAS 1014-70-6 Simetryn

Simetryn
(CAS: 1014-70-6)

Simetryn, a methylthiotriazine derivative, is a herbicide which is commonly used in rice paddy. LC50: 16.9-3.70 mg/L (79.3-17.4 microM).

CAS 7491-74-9 Piracetam

Piracetam
(CAS: 7491-74-9)

Piracetam is a prototypical nootropic which modulates Na+-flux at AMPA receptors.

CAS 225521-80-2 BMS-243117

BMS-243117
(CAS: 225521-80-2)

BMS-243117 is a potent and selective Lck inhibitor with good cellular activity against T-cell proliferation. BMS-24311 has potential to treat diseases such as r...

CAS 98769-84-7 Reboxetine mesylate

Reboxetine mesylate
(CAS: 98769-84-7)

Reboxetine is a norepinephrine reuptake inhibitor with Ki of 8.2 nM.

MK785
(CAS: 14760-71-5)

MK785, an imidazol derivative, has been found to inhibit the formation of aortic histamine through influencing the aortic histidine decarboxylase at some extent...

CAS 52286-74-5 Ginsenoside Rg2

Ginsenoside Rg2
(CAS: 52286-74-5)

Ginsenoside Rf, extracted from the traditional Chinese herb ginseng used as an aldose reductase inhibitor and my exert anti-inflammatory and immunomodulatory ac...

CAS 480-18-2 Taxifolin

Taxifolin
(CAS: 480-18-2)

Taxifolin is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on. Taxifolin has shown to inhibit the ovarian cancer cel...

GSK-2262167 sodium
(CAS: 458576-13-0)

GSK-2262167 is a potent S1P3-sparing and S1P1 agonist and has a potent activity is in a collagen-induced arthritis model as efficacious as fingolimod and show...

7DW8-5

7DW8-5, a novel glycolipid, an analog of α-galactosylceramide (α-GalCer), is an immunostimulate iNKT agonist and a vaccine adjuvant that can harness and amplify...

CHEMBL2426474
(CAS: 1418741-86-2)

CHEMBL2426474, also called as UNC1079, the piperidine analog of UNC1021 that has binding affinity to L3MBTL3 in human G401 cells by Western blot based pulldown ...

AM-156
(CAS: 1224977-85-8)

Prostanoid GD(2) is released from mast cells in response to allergen challenge. AM156 is a selective prostanoid DP(2) receptor antagonist and it inhibits sneezi...

CAS 769856-81-7 TPT-260

TPT-260
(CAS: 769856-81-7)

TPT-260 is a thiophene thiourea derivative with molecule weight 260.00 in free base form.

Chemical Structure

CAS 6537-80-0 Chicoric acid

Quick Inquiry

Verification code

Featured Items