CHF 5074 - CAS 749269-83-8
Catalog number:
749269-83-8
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C16H11Cl2FO2
Molecular Weight:
325.16
COA:
Inquire
Targets:
γ-secretase
Description:
CHF5074, also known as CSP-1103, is a novel γ-secretase modulator. It could reduce Aβ42 and Aβ40 secretion, which IC50 value is 3.6 and 18.4 μM respectively. It induces microglia alternative activation in plaque-free Tg2576 mice and primary glial cultures exposed to beta-amyloid. It restores visual memory ability and pre-synaptic cortical acetylcholine release in pre-plaque Tg2576 mice. In vitro, it significantly reduces the area occupied by plaques and the number of plaques in cortex and hippocampus. It reduces brain beta-Amyloid pathology in a transgenic mouse model of Alzheimer's Disease without causing peripheral toxicity. It is a non-steroidal anti-inflammatory derivative holding disease-modifying potential for the treatment of Alzheimer's disease. It significantly reduces the apoptosis in hippocampal neurons exposed to OGD, as revealed by cleaved-caspase-3 immunoreactivity and TUNEL staining. It protects SH-SY5Y human neuronal-like cells from amyloidbeta 25-35 and tumor necrosis factor related apoptosis inducing ligand toxicity in vitro. In vivo, it was well tolerated by Tg2576 mice. It is orally well absorbed (50%), and it is slowly eliminated from plasma in rats.
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Purity:
98%
Appearance:
Solid powder
Synonyms:
CSP-1103;1-[4-(3,4-dichlorophenyl)-3-fluorophenyl]cyclopropane-1-carboxylic acid;1-(3′,4′-Dichloro-2-fluoro[1,1′-biphenyl]-4-yl)-cyclopropanecarboxylic acid
Solubility:
DMSO:37mg/mL
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
CHF5074 induces microglia alternative activation in plaque-free Tg2576 mice and primary glial cultures exposed to beta-amyloid. It restores visual memory ability and pre-synaptic cortical acetylcholine release in pre-plaque Tg2576 mice. It is a non-steroidal anti-inflammatory derivative holding disease-modifying potential for the treatment of Alzheimer's disease. It significantly reduces the apoptosis in hippocampal neurons exposed to OGD, as revealed by cleaved-caspase-3 immunoreactivity and TUNEL staining.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Boiling Point:
466.4±45.0 °C | Condition: Press: 760 Torr
Density:
1.467±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
LIYLTQQDABRNRX-UHFFFAOYSA-N
InChI:
InChI=1S/C16H11Cl2FO2/c17-12-4-1-9(7-13(12)18)11-3-2-10(8-14(11)19)16(5-6-16)15(20)21/h1-4,7-8H,5-6H2,(H,20,21)
Canonical SMILES:
C1CC1(C2=CC(=C(C=C2)C3=CC(=C(C=C3)Cl)Cl)F)C(=O)O
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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CAS 749269-83-8 CHF 5074

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