CHAPS - CAS 75621-03-3
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Not Intended for Therapeutic Use. For research use only.
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CHAPS is a zwitterionic nondenaturing detergent for solubilizing membrane proteins. It is often used as a detergent in the solubilization and purification of membrane proteins for several advantageous reasons. It is also useful in ion exchange chromatography and isoelectric focusing as it is zwitterionic and does not exhibit a net charge between pH 2 to 12.
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1.The antioxidant protein PARK7 plays an improtant role in cell resistance to Cisplatin-induced apoptosis in case of clear cell renal cell carcinoma.
Trivedi R1, Dihazi GH2, Eltoweissy M2, Mishra DP3, Mueller GA2, Dihazi H4. Eur J Pharmacol. 2016 Apr 22. pii: S0014-2999(16)30226-6. doi: 10.1016/j.ejphar.2016.04.014. [Epub ahead of print]
Clear cell renal cell carcinoma (ccRCC) is the most malignant tumor in the adult kidney. Many factors are responsible for the development and progression of this tumor. Increased reactive oxygen species accumulation and altered redox status have been observed in cancer cells and this biochemical property of cancer cells can be exploited for therapeutic benefits. In earlier work we identified and characterize Protein DJ-1 (PARK7) as an oxidative stress squevenger in renal cells exposed to oxidative stress. To investigate whether the PARK7 or other oxidative stress proteins play a role in the renal cell carcinoma and its senstivity or resistance to cytostatic drug treatment, differential proteomics analysis was performed with a cell model for clear cell renal carcinoma (Caki-2 and A498). Caki-2 cells were treated with cisplatin and differentially expressed proteins were investigated. The cisplatin treatment resulted in an increase in reactive oxygen species accumulation and ultimately apoptosis of Caki-2 and A498 cells.
2.Purification and characterization of an alkali-thermostable lipase from thermophilic Anoxybacillus flavithermus HBB 134.
Bakir ZB1, Metin K1. J Microbiol Biotechnol. 2016 Mar 24. doi: 10.4014/jmb.1512.12056. [Epub ahead of print]
An intracellular lipase from Anoxybacillus flavithermus HBB 134 was purified to 7,4 fold. Molecular weight of the enzyme was found to be about 64 kDa. The enzyme showed maximum activity at pH 9.0 and 50 °C. It was determined that the enzyme was stable for 24 hour between pH 6.0-11.0 and at 25, 40 and 50 °C. It was found that the Km and Vmax of the enzyme for pNPL substrate were 0.084 mM and 500 U/mg respectively. Glycerol, sorbitol and mannitol enhanced the enzyme thermostability. The enzyme was found to be highly stable against acetone, ethyl acetate and diethyl ether. The enzyme activity was inhibited in the presence of PMSF, NBS, DTT and β-mercaptoethanole. Hg2+, Fe3+, Pb2+, Al3+ and Zn2+ strongly inhibited the enzyme while Li+, Na+, K+ and NH4+ slightly activated. At least 60 % of the enzyme activity and stability were retained against sodium deoxycholate, sodium taurocholate, n-octyl-β-D-glucopyranoside and CHAPS. The enzyme activity was elevated about 34 % in the presence of 1 % Triton X-100.
3.Dynamic assembly of the exomer secretory vesicle cargo adaptor subunits.
Huranova M1, Muruganandam G1, Weiss M2, Spang A3. EMBO Rep. 2016 Feb;17(2):202-19. doi: 10.15252/embr.201540795. Epub 2016 Jan 7.
The trans-Golgi network (TGN) is the main secretory pathway sorting station, where cargoes are packed into appropriate transport vesicles targeted to specific destinations. Exomer is a cargo adaptor necessary for direct transport of a subset of cargoes from the TGN to the plasma membrane in yeast. Here, we show that unlike classical adaptor complexes, exomer is not recruited en bloc to the TGN, but rather assembles through a stepwise pathway, in which first the scaffold protein Chs5 and then the cargo-binding units, the ChAPs, are recruited. Although all ChAPs are able to assemble functional exomer complexes, they do so with different efficiencies. The mutual relationship between ChAPs varies from cooperation to competition depending on their expression levels and affinities to Chs5 allowing an optimized and efficient cargo transport. The multifactorial assembly pathway results in an exquisitely fine-tuned adaptor complex, enabling the cell to quickly respond and adapt to changes such as stress.
4.Influence of pre-existing inflammation on the outcome of acute coronary syndrome: a cross-sectional study.
Odeberg J1, Freitag M2, Forssell H3, Vaara I4, Persson ML4, Odeberg H3, Halling A5, Råstam L2, Lindblad U6. BMJ Open. 2016 Jan 12;6(1):e009968. doi: 10.1136/bmjopen-2015-009968.
OBJECTIVES: Inflammation is a well-established risk factor for the development of coronary artery disease (CAD) and acute coronary syndrome (ACS). However, less is known about its influence on the outcome of ACS. The aim of this study was to determine if blood biomarkers of inflammation were associated specifically with acute myocardial infarction (MI) or unstable angina (UA) in patients with ACS.
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CAS 75621-03-3 CHAPS

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