CH5138303 - CAS 959763-06-5
Catalog number:
959763-06-5
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C19H18ClN5O2S
Molecular Weight:
415.90
COA:
Inquire
Targets:
Hsp90
Description:
CH5138303 is a novel and potent Hsp90 inhibitor. CH5138303 showed high binding affinity for N-terminal Hsp90α (Kd=0.52nM) and strong in vitro cell growth inhibition against human cancer cell lines (HCT116 IC50=0.098μM, NCI-N87 IC50=0.066μM) and also displayed high oral bioavailability in mice (F=44.0%) and potent antitumor efficacy in a human NCI-N87 gastric cancer xenograft model (tumor growth inhibition=136%).
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Brife Description:
CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.
Purity:
>98%
Appearance:
White solid powder
Synonyms:
CH-5138303; CH 5138303
Solubility:
DMSO: 83 mg/mL
Storage:
3 years -20oC powder, 6 months-80oC in solvent.
MSDS:
Inquire
Quality Standard:
In-house
Quantity:
Grams-Kilos
InChIKey:
VIGHQZSTZWNWFA-UHFFFAOYSA-N
InChI:
InChI=1S/C19H18ClN5O2S/c20-13-7-11-9-27-8-10-3-1-4-12(15(10)11)16(13)17-23-18(22)25-19(24-17)28-6-2-5-14(21)26/h1,3-4,7H,2,5-6,8-9H2,(H2,21,26)(H2,22,23,24,25)
Canonical SMILES:
C1C2=CC=CC3=C2C(=CC(=C3C4=NC(=NC(=N4)SCCCC(=O)N)N)Cl)CO1
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CAS 959763-06-5 CH5138303

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