|Description||CH5138303 is a novel and potent Hsp90 inhibitor. CH5138303 showed high binding affinity for N-terminal Hsp90α (Kd=0.52nM) and strong in vitro cell growth inhibition against human cancer cell lines (HCT116 IC50=0.098μM, NCI-N87 IC50=0.066μM) and also displayed high oral bioavailability in mice (F=44.0%) and potent antitumor efficacy in a human NCI-N87 gastric cancer xenograft model (tumor growth inhibition=136%).|
|Brife Description||CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.|
|Appearance||White solid powder|
|Synonyms||CH-5138303; CH 5138303|
|Solubility||DMSO: 83 mg/mL|
|Storage||3 years -20oC powder, 6 months-80oC in solvent.|
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