CH 141 - CAS 78279-88-6
Catalog number: 78279-88-6
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C19-H21-N3-O
Molecular Weight:
307.39
COA:
Inquire
Targets:
Others
Description:
CH 141 is a peripheral vasodilator.
Purity:
98%
Appearance:
Powder
Synonyms:
6-((3,4-dihydroisoquinolin-2(1H)-yl)methyl)-3-phenyl-5,6-dihydro-2H-1,2,4-oxadiazine; CH 141; CH-141; CH141; Pthiqdo.
Solubility:
Soluble in DMSO
Storage:
-20℃ Freezer
MSDS:
Inquire
Application:
peripheral vasodilator
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
GWAKPCRBHTWEKQ-UHFFFAOYSA-N
InChI:
1S/C19H21N3O/c1-2-7-16(8-3-1)19-20-12-18(23-21-19)14-22-11-10-15-6-4-5-9-17(15)13-22/h1-9,18H,10-14H2,(H,20,21)
Canonical SMILES:
c1ccc(cc1)C2=NCC(ON2)CN3CCc4ccccc4C3
1.High performance liquid chromatographic determination of a new biologically active 1,2,4-oxadiazine derivative in rat plasma.
Mezei J;Küttel S;Szemere L;Rácz I Pharmazie. 1984 Jun;39(6):399-400.
A sensitive high performance liquid chromatographic procedure was developed for the determination of 3-phenyl-6-(1,2,3,4-tetrahydro-2-isoquinolyl)methyl-4H-5,6-dihydro -1,2, 4-oxadiazine a new vasodilator, in plasma. Rat plasma samples were made alkaline with ammonia and partitioned with chloroform. The extracts were dried with anhydrous sodium sulphate and evaporated to dryness under reduced pressure. The residues were redissolved in chloroform, and then chromatographed on silica column with chloroform/isopropanol (7:3, v/v). Detection was performed with a variable-wavelength UV detector set at 265 nm. Limit of identification was 10 ng, that of quantitative determination 50 ng 1/ml of plasma. The utility of the method for pharmacokinetic studies in the rat was demonstrated.
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