CGP-53153 - CAS 149281-19-6
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C23H33N3O2
Molecular Weight:
383.53
COA:
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Targets:
5 alpha Reductase
Description:
CGP-53153 is a steroidal inhibitor of 5 alpha reductase is a steroidal which effects the conversion of testosterone (T) to 5α-dihydrotestosterone (DHT). In vitro, CGP 53153 competitively inhibited rat microsomal 5α-reductase from prostate by 50% (ICs0) at a concentration of 36 nM compared to the reference compound finasteride which inhibited 5α-reductase with an ICs0 of 11 nM in the same system. In vivo, inhibition of 5α-reductase activity was characterized in three different test systems.
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Synonyms:
(1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-(2-cyanopropan-2-yl)-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide; wt1-ricin a; SCHEMBL8823373; CGP 53153
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
Boiling Point:
627.0±55.0 ℃ at 760 Torr
Density:
1.118±0.06 g/cm3
InChIKey:
OESNKOKTKJVMIR-WSBQPABSSA-N
InChI:
1S/C23H33N3O2/c1-21(2,13-24)26-20(28)17-7-6-15-14-5-8-18-23(4,12-10-19(27)25-18)16(14)9-11-22(15,17)3/h10,12,14-18H,5-9,11H2,1-4H3,(H,25,27)(H,26,28)/t14-,15-,16-,17+,18+,22-,23+/m0/s1
Canonical SMILES:
CC12CCC3C(C1CCC2C(=O)NC(C)(C)C#N)CCC4C3(C=CC(=O)N4)C
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Chemical Structure

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