|Targets||5 alpha Reductase|
|Description||CGP-53153 is a steroidal inhibitor of 5 alpha reductase is a steroidal which effects the conversion of testosterone (T) to 5α-dihydrotestosterone (DHT). In vitro, CGP 53153 competitively inhibited rat microsomal 5α-reductase from prostate by 50% (ICs0) at a concentration of 36 nM compared to the reference compound finasteride which inhibited 5α-reductase with an ICs0 of 11 nM in the same system. In vivo, inhibition of 5α-reductase activity was characterized in three different test systems.|
|Synonyms||(1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-(2-cyanopropan-2-yl)-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide; wt1-ricin a; SCHEMBL8823373; CGP 53153|
|Storage||Store in a cool and dry place (or refer to the Certificate of Analysis).|
|Boiling Point||627.0±55.0 ℃ at 760 Torr|
Finasteride (INN, USAN, BAN) (brand names Proscar, and Propecia by Merck, among other generic names; former developmental code name MK-906) is a drug used for t...
Finasteride acetate is a specific inhibitor of 5α-reductase. Finasteride can be used in the treatment of men with benign prostatic, and through the assessment o...
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Dutasteride is a dual 5-α reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone (DHT).
CGP-53153 is a steroidal inhibitor of 5 alpha reductase is a steroidal which effects the conversion of testosterone (T) to 5α-dihydrotestosterone (DHT). In vitr...