|Description||CGP 52411, also called DAPH, inhibits and reverses the formation of Aβ42 fibers (β-sheet content of aggregated β-amyloid (1-42): IC50 = 4.5 µM) in neurons associated with Alzheimer's disease. And it is also a selective inhibitor of the epidermal growth factor receptor (EGFR) (IC50 = 0.3 μM in vitro).|
|Brife Description||Inhibits and reverses the formation of Aβ42 fibers associated with Alzheimer's disease; β-sheet content of aggregated β-amyloid (1-42): IC50 = 4.5 µM; EGFR: IC50 = 0.3 µM|
|Synonyms||5,6-dianilinoisoindole-1,3-dione; 406-050-3; Z13D008FZ2; 4,5-dianilinophthalimide; DAPH; Cgp 52411; 5,6-Bis(phenylamino)-1H-isoindole-1,3(2H)-dione; 145915-58-8; Cgp-52411; UNII-Z13D008FZ2; CHEMBL268868; 5,6-dianilino-1h-isoindole-1,3(2h)-dione; CHEBI:53110; Z13D008FZ2; AC1Q6JME; DAPH-1; SCHEMBL11017; 4,5-Bis(anilino)phthalimide; D3943_SIGMA; 4,5-bis-(anilino)phthalimide; AC1L1C19; ZINC6094; DTXSID4040393; CTK8D4606; AAALVYBICLMAMA-UHFFFAOYSA-N; BCPP000288; HMS3260P13; 5,6-dianilinoisoindole-1,3-dione; Tox21_500236; ABP000886; AR-1G6110; BDBM50040929; MFCD00236442; AKOS024457581; BCP9000511; CCG-221540; LP00236; CGP 52411/CGP52411; NCGC00093700-01; NCGC00093700-02; NCGC00093700-03; NCGC00093700-04; NCGC00093700-05; NCGC00260921-01; AK393267; HE062397; HE312151; 5,6-Bis-phenylamino-isoindole-1,3-dione; 5,6-Bis(phenylamino)isoindoline-1,3-dione; J587.895K; 1H-Isoindole-1,3(2H)-dione, 5,6-bis(phenylamino)-; BRD-K13087974-001-01-7; CGP 52411|DAPH|5,6-Bis(phenylamino)-1H-isoindole-1,3(2H)-dione|
|Solubility||Soluble to 100 mM in DMSO and to 25 mM in ethanol|
|Storage||Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -26℃ for long term (months to years).|
|Application||Anti-Alzheimer agents; Amyloid-β inhibitor|
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