CGP 52411 - CAS 145915-58-8
Catalog number:
145915-58-8
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C20H15N3O2
Molecular Weight:
329.35
COA:
Inquire
Targets:
Amyloid-β
Description:
CGP 52411, also called DAPH, inhibits and reverses the formation of Aβ42 fibers (β-sheet content of aggregated β-amyloid (1-42): IC50 = 4.5 µM) in neurons associated with Alzheimer's disease. And it is also a selective inhibitor of the epidermal growth factor receptor (EGFR) (IC50 = 0.3 μM in vitro).
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Brife Description:
Inhibits and reverses the formation of Aβ42 fibers associated with Alzheimer's disease; β-sheet content of aggregated β-amyloid (1-42): IC50 = 4.5 µM; EGFR: IC50 = 0.3 µM
Appearance:
Yellow solid
Synonyms:
5,6-dianilinoisoindole-1,3-dione; 406-050-3; Z13D008FZ2; 4,5-dianilinophthalimide; DAPH; Cgp 52411; 5,6-Bis(phenylamino)-1H-isoindole-1,3(2H)-dione; 145915-58-8; Cgp-52411; UNII-Z13D008FZ2; CHEMBL268868; 5,6-dianilino-1h-isoindole-1,3(2h)-dione; CHEBI:53110; Z13D008FZ2; AC1Q6JME; DAPH-1; SCHEMBL11017; 4,5-Bis(anilino)phthalimide; D3943_SIGMA; 4,5-bis-(anilino)phthalimide; AC1L1C19; ZINC6094; DTXSID4040393; CTK8D4606; AAALVYBICLMAMA-UHFFFAOYSA-N; BCPP000288; HMS3260P13; 5,6-dianilinoisoindole-1,3-dione; Tox21_500236; ABP000886; AR-1G6110; BDBM50040929; MFCD00236442; AKOS024457581; BCP9000511; CCG-221540; LP00236; CGP 52411/CGP52411; NCGC00093700-01; NCGC00093700-02; NCGC00093700-03; NCGC00093700-04; NCGC00093700-05; NCGC00260921-01; AK393267; HE062397; HE312151; 5,6-Bis-phenylamino-isoindole-1,3-dione; 5,6-Bis(phenylamino)isoindoline-1,3-dione; J587.895K; 1H-Isoindole-1,3(2H)-dione, 5,6-bis(phenylamino)-; BRD-K13087974-001-01-7; CGP 52411|DAPH|5,6-Bis(phenylamino)-1H-isoindole-1,3(2H)-dione
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -26℃ for long term (months to years).
MSDS:
Inquire
Application:
Anti-Alzheimer agents; Amyloid-β inhibitor
InChIKey:
AAALVYBICLMAMA-UHFFFAOYSA-N
InChI:
1S/C20H15N3O2/c24-19-15-11-17(21-13-7-3-1-4-8-13)18(12-16(15)20(25)23-19)22-14-9-5-2-6-10-14/h1-12,21-22H,(H,23,24,25)
Canonical SMILES:
C1=CC=C(C=C1)NC2=C(C=C3C(=C2)C(=O)NC3=O)NC4=CC=CC=C4
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Chemical Structure

CAS 145915-58-8 CGP 52411

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