CFI-400945 - CAS 1338806-73-7
Catalog number:
1338806-73-7
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C33H34N4O3
Molecular Weight:
534.66
COA:
Inquire
Targets:
Ser/Thr Protease
Description:
CFI-400945 is a PLK4 (polo-like kinase 4) inhibitor with potential antineoplastic activity originated by University Health Network. It can selectively inhibit PLK4, which leads to the disruption of mitosis and the induction of apoptosis. Phase I clinical trials for the treatment of solid tumor is on-going.
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Purity:
98%
Appearance:
Powder
Synonyms:
AK173721; SCHEMBL9946383; AKOS025396133;(2'S,3R)-2'-[3-[(E)-2-[4-[[(2S,6R)-2,6-dimethylmorpholin-4-yl]methyl]phenyl]ethenyl]-1H-indazol-6-yl]-5-methoxyspiro[1H-indole-3,1'-cyclopropane]-2-one;1616420-30-4 (CFI-400945 fumarate)
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Solid tumor
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
DADASRPKWOGKCU-FVTQAUBDSA-N
InChI:
InChI=1S/C33H34N4O3/c1-20-17-37(18-21(2)40-20)19-23-6-4-22(5-7-23)8-12-29-26-11-9-24(14-31(26)36-35-29)28-16-33(28)27-15-25(39-3)10-13-30(27)34-32(33)38/h4-15,20-21,28H,16-19H2,1-3H3,(H,34,38)(H,35,36)/b12-8+/t20-,21+,28-,33-/m0/s1
Canonical SMILES:
CC1CN(CC(O1)C)CC2=CC=C(C=C2)C=CC3=NNC4=C3C=CC(=C4)C5CC56C7=C(C=CC(=C7)OC)NC6=O
Current Developer:
University Health Network
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