Cevimeline hydrochloride - CAS 107220-28-0
Catalog number: 107220-28-0
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C10H18ClNOS
Molecular Weight:
235.77
COA:
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Targets:
mAChR
Description:
Cevimeline hydrochloride is a selective M1 receptor agonist.
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Purity:
>98%
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1.Comparison of the discontinuation rates and side-effect profiles of pilocarpine and cevimeline for xerostomia in primary Sjögren's syndrome.
Noaiseh G1, Baker JF, Vivino FB. Clin Exp Rheumatol. 2014 Jul-Aug;32(4):575-7. Epub 2014 Jul 23.
OBJECTIVES: There are currently no head-to-head comparisons of sialagogues for Primary Sjögren's syndrome (pSS). We compared the tolerability and side effect profile of pilocarpine and cevimeline in patients with pSS and determined clinical, laboratory and pathological variables associated with therapeutic failure.
2.Structural characterization of cevimeline and its trans-impurity by single crystal XRD.
Stepanovs D1, Tetere Z2, Rāviņa I2, Kumpiņš V2, Zicāne D2, Bizdēna Ē2, Bogans J3, Novosjolova I2, Grigaloviča A2, Meri RM2, Fotins J4, Čerkasovs M4, Mishnev A1, Turks M5. J Pharm Biomed Anal. 2016 Jan 25;118:404-9. doi: 10.1016/j.jpba.2015.11.006. Epub 2015 Nov 14.
Cevimeline is muscarinic receptor agonist which increases secretion of exocrine glands. Cevimeline base is a liquid (m.p. 20-25 °C) at ambient conditions, therefore its pharmaceutical formulation as a solid hydrochloride hemihydrate has been developed. The synthesis of cevimeline yields its cis- and trans-isomers and only the cis-isomer is recognized as the API and used in the finished formulation. In this study structural and physicochemical investigations of hydrochloride hemihydrates of cis- and trans-cevimelines have been performed. Single crystal X-ray analyses of both cis- and trans-isomers of cevimeline are reported here for the first time. It was found that the cis-isomer, the API, has less dense crystal packing, lower melting point and higher solubility in comparison to the trans-isomer.
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CAS 107220-28-0 Cevimeline hydrochloride

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