Cevimeline hydrochloride - CAS 107220-28-0
Catalog number: 107220-28-0
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C10H18ClNOS
Molecular Weight:
235.77
COA:
Inquire
Targets:
mAChR
Description:
Cevimeline hydrochloride is a selective M1 receptor agonist.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
MSDS:
Inquire
1.Comparison of the discontinuation rates and side-effect profiles of pilocarpine and cevimeline for xerostomia in primary Sjögren's syndrome.
Noaiseh G1, Baker JF, Vivino FB. Clin Exp Rheumatol. 2014 Jul-Aug;32(4):575-7. Epub 2014 Jul 23.
OBJECTIVES: There are currently no head-to-head comparisons of sialagogues for Primary Sjögren's syndrome (pSS). We compared the tolerability and side effect profile of pilocarpine and cevimeline in patients with pSS and determined clinical, laboratory and pathological variables associated with therapeutic failure.
2.Structural characterization of cevimeline and its trans-impurity by single crystal XRD.
Stepanovs D1, Tetere Z2, Rāviņa I2, Kumpiņš V2, Zicāne D2, Bizdēna Ē2, Bogans J3, Novosjolova I2, Grigaloviča A2, Meri RM2, Fotins J4, Čerkasovs M4, Mishnev A1, Turks M5. J Pharm Biomed Anal. 2016 Jan 25;118:404-9. doi: 10.1016/j.jpba.2015.11.006. Epub 2015 Nov 14.
Cevimeline is muscarinic receptor agonist which increases secretion of exocrine glands. Cevimeline base is a liquid (m.p. 20-25 °C) at ambient conditions, therefore its pharmaceutical formulation as a solid hydrochloride hemihydrate has been developed. The synthesis of cevimeline yields its cis- and trans-isomers and only the cis-isomer is recognized as the API and used in the finished formulation. In this study structural and physicochemical investigations of hydrochloride hemihydrates of cis- and trans-cevimelines have been performed. Single crystal X-ray analyses of both cis- and trans-isomers of cevimeline are reported here for the first time. It was found that the cis-isomer, the API, has less dense crystal packing, lower melting point and higher solubility in comparison to the trans-isomer.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related mAChR Products


CAS 50-34-0 Propantheline Bromide

Propantheline Bromide
(CAS: 50-34-0)

Propantheline Bromide is an antimuscarinic agent used as an antispasmodic for the treatment of ulcers.

CAS 1508-65-2 Oxybutynin chloride

Oxybutynin chloride
(CAS: 1508-65-2)

Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties.

CAS 596-51-0 Glycopyrrolate bromide

Glycopyrrolate bromide
(CAS: 596-51-0)

Glycopyrrolate bromide is a muscarinic competitive antagonist used as an antispasmodic.

CAS 5908-99-6 Atropine sulfate salt monohydrate

Atropine sulfate salt monohydrate
(CAS: 5908-99-6)

Atropine is a competitive muscarinic acetylcholine receptor antagonist with an IC50 of 2.5 nM.

CAS 286930-03-8 Fesoterodine Fumarate

Fesoterodine Fumarate
(CAS: 286930-03-8)

Fesoterodine Fumarate is an antimuscarinic agent and is rapidly de-esterified to its active metabolite 5-hydroxymethyl tolterodine that is a muscarinic receptor...

CAS 51-56-9 Homatropine Bromide

Homatropine Bromide
(CAS: 51-56-9)

Homatropine Bromide is an muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 1...

CAS 171722-81-9 YM-46303

YM-46303
(CAS: 171722-81-9)

YM-46303 is an mAChR antagonist which had a binding affinity of 0.39 nM to M3-receptors. YM-46303 exhibits the highest affinities for M1 and M3 receptors. YM-46...

CAS 113-69-9 Benzquinamide Hydrochloride

Benzquinamide Hydrochloride
(CAS: 113-69-9)

Benzquinamide hydrochloride is an antiemetic compound with antihistaminic, anticholinergic and sedative properties. The mechanism of action is not quite sure an...

CAS 76-90-4 Mepenzolate Bromide

Mepenzolate Bromide
(CAS: 76-90-4)

Mepenzolate Bromide is a muscarinic antagonist used to treat gastrointestinal disorders, and decreases the severity of elastase-induced airspace enlargement and...

CAS 139404-48-1 Tiotropium Bromide hydrate

Tiotropium Bromide hydrate
(CAS: 139404-48-1)

Tiotropium Bromide hydrate is a monohydrate of tiotropium bromide (Spiriva; Tiova; BA 679BR; tiopropium) that is an anticholinergic and bronchodilator and a mus...

CAS 120241-31-8 Alvameline

Alvameline
(CAS: 120241-31-8)

Alvameline, also known as Lu25-109, is a partial M1agonist and M2/M3antagonist that was progressed into clinical studies for the treatment of Alzheimer's diseas...

CI 969
(CAS: 113590-49-1)

This active molecular is a muscarinic agonist agent.

PF-06767832
(CAS: 1859081-58-5)

PF-06767832 is a cell permeable, potent and selective M1 muscarinic acetylcholine receptor Positive Allosteric Modulator (PAM).

CAS 326001-01-8 VU 0029767

VU 0029767
(CAS: 326001-01-8)

VU 0029767 is a positive allosteric modulator of M1, a member of the muscarinic acetylcholine family of GPCRs (mAChRs). VU 0029767 enhances the competitive effe...

CAS 2092923-21-0 VU 6008667

VU 6008667
(CAS: 2092923-21-0)

VU 6008667 is a selective negative allosteric modulator (NAM) of M5 muscarinic acetylcholine receptor (mAChR) (IC50 values of 1.2 and 1.6 μM in human and rat M5...

BQCA
(CAS: 338747-41-4)

BQCA is a highly selective positive allosteric modulator of the M1 muscarinic acetylcholine receptor (mAChR), as it dose-dependently reduces the concentration o...

CAS 145-13-1 Pregnenolone

Pregnenolone
(CAS: 145-13-1)

Pregnenolone is an endogenous steroid hormone for inhibition of M1 receptor- and M3 receptor-mediated currents with IC50 of 11.4 μM and 6.0 μM, respectively.

CAS 1159101-48-0 Tarafenacin D-tartrate

Tarafenacin D-tartrate
(CAS: 1159101-48-0)

Tarafenacin is a highly selective M3 muscarinic receptor antagonist (Ki=0.19 nM), ~200 fold selectivity over M2 receptor.

CAS 207679-81-0 (R)-5-Hydroxymethyl tolterodine

(R)-5-Hydroxymethyl tolterodine
(CAS: 207679-81-0)

5-hydroxymethyl tolterodine produces a competitive and concentration-dependent inhibition of carbachol-induced contraction of guinea-pig isolated urinary bladde...

CAS 514-65-8 Biperiden

Biperiden
(CAS: 514-65-8)

Biperiden is an antiparkinsonian agent, which is the selective central M1 cholinoreceptors blocker. It is used for the adjunctive treatment of all forms of Park...

Chemical Structure

CAS 107220-28-0 Cevimeline hydrochloride

Quick Inquiry

Verification code

Featured Items