1.Voriconazole-Loaded Nanostructured Lipid Carriers for Ocular Drug Delivery.
Andrade LM1, Rocha KA, De Sá FA, Marreto RN, Lima EM, Gratieri T, Taveira SF. Cornea. 2016 Apr 6. [Epub ahead of print]
PURPOSE: To design and evaluate the potential of a topical delivery system for ocular administration of voriconazole, based on cationic nanostructured lipid carriers (NLCs).
2.Effects of a mouthwash containing potassium nitrate, sodium fluoride, and cetylpyridinium chloride on dentin hypersensitivity: a randomized, double-blind, placebo-controlled study.
Hong JY1, Lim HC1, Herr Y1. J Periodontal Implant Sci. 2016 Feb;46(1):46-56. doi: 10.5051/jpis.2016.46.1.46. Epub 2016 Feb 15.
PURPOSE: We evaluated the efficacy of a mouthwash containing potassium nitrate (KNO3) as its main component, along with sodium fluoride (NaF) and cetylpyridinium chloride (CPC). The primary endpoint was the relief of dentin hypersensitivity (DH) against the cold stimuli. The effects on other DH tests and periodontal inflammation were also evaluated.
3.Automation of antimicrobial activity screening.
Forry SP1, Madonna MC2, López-Pérez D2,3, Lin NJ2, Pasco MD2. AMB Express. 2016 Mar;6(1):20. doi: 10.1186/s13568-016-0191-2. Epub 2016 Mar 12.
Manual and automated methods were compared for routine screening of compounds for antimicrobial activity. Automation generally accelerated assays and required less user intervention while producing comparable results. Automated protocols were validated for planktonic, biofilm, and agar cultures of the oral microbe Streptococcus mutans that is commonly associated with tooth decay. Toxicity assays for the known antimicrobial compound cetylpyridinium chloride (CPC) were validated against planktonic, biofilm forming, and 24 h biofilm culture conditions, and several commonly reported toxicity/antimicrobial activity measures were evaluated: the 50 % inhibitory concentration (IC50), the minimum inhibitory concentration (MIC), and the minimum bactericidal concentration (MBC). Using automated methods, three halide salts of cetylpyridinium (CPC, CPB, CPI) were rapidly screened with no detectable effect of the counter ion on antimicrobial activity.
4.Evolution of resistance to cationic biocides in Streptococcus mutans and Enterococcus faecalis.
Kitagawa H1, Izutani N2, Kitagawa R2, Maezono H2, Yamaguchi M2, Imazato S3. J Dent. 2016 Apr;47:18-22. doi: 10.1016/j.jdent.2016.02.008. Epub 2016 Feb 22.
OBJECTIVES: The aim of this study was to investigate whether Streptococcus mutans and Enterococcus faecalis develop resistance to the cationic biocides chlorhexidine (CHX), cetylpyridinium chloride (CPC), and 12-methacryloyloxydodecylpyridinium bromide (MDPB).