Cetirizine diHCl - CAS 83881-52-1
Catalog number: 83881-52-1
Category: Inhibitor
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Molecular Formula:
C21H26Cl2N2O3
Molecular Weight:
425.35
COA:
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Targets:
Histamine Receptor
Description:
Cetirizine is a major metabolite of hydroxyzine, and a racemic selective H1 receptor antagonist.
Purity:
>98%
Synonyms:
Vitamin B2
MSDS:
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InChIKey:
PGLIUCLTXOYQMV-UHFFFAOYSA-N
InChI:
InChI=1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H
Canonical SMILES:
C1CN(CCN1CCOCC(=O)O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl.Cl.Cl
1.Suppression of histamine-induced skin reactions by loratadine and cetirizine diHCl.
Kontou-Fili K1, Paleologos G, Herakleous M. Eur J Clin Pharmacol. 1989;36(6):617-9.
The skin reactivity to histamine was measured in 10 healthy and 10 atopic subjects after the ingestion of single doses of loratadine 10 mg, cetirizine diHCl 10 mg and placebo, in a double-blind cross-over randomized study. The anti-H1 effect of cetirizine diHCl proved to be significantly more rapid, more pronounced and longer lasting than that of loratadine.
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CAS 83881-52-1 Cetirizine diHCl

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