Ceralifimod - CAS 891859-12-4
Catalog number:
891859-12-4
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C27H33NO4
Molecular Weight:
435.564
COA:
Inquire
Targets:
Sphingosine-1-phosphate receptor 1(S1PR1)
Description:
Ceralifimod (ONO-4641) is a selective agonist of sphingosine 1-phosphate (S1P) receptor 1 and 5 (EC50 = 0.0273 and 0.334 nM). In animal experiment, ONO-4641 prevented relapse of disease in a non-obese diabetic mouse model of relapsing-remitting EAE. ONO-4641 had been developed for the treatment of multiple sclerosis (MS) and undergone a phase II clinical trial by Merck KGaA and Ono, therefore, the study were terminated in Dec 2014.
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Brife Description:
sphingosine 1-phosphate (S1P) receptor 1 and 5 agonist, multiple sclerosis (MS)
Purity:
≥98%
Appearance:
Solid Powder
Synonyms:
UNII-BZ2O8A84A4; 891859-12-4; AK173892; Ceralifimod [INN]; SCHEMBL465051; 1-[[6-[(2-methoxy-4-propylphenyl)methoxy]-1-methyl-3,4-dihydronaphthalen-2-yl]methyl]azetidine-3-carboxylic acid
Solubility:
Soluble in DMSO.
Storage:
Store in a cool and dry place and at 0-4 ℃ for short term (days to weeks) or -66 ℃ for long term (months to years).
MSDS:
Inquire
Application:
Ceralifimod (ONO-4641) is a selective agonist of sphingosine 1-phosphate (S1P) receptor 1 and 5 (EC50 = 0.0273 and 0.334 nM) developed for the treatment of multiple sclerosis (MS).
Shelf Life:
2 years
InChIKey:
QDDQIPUKAXBMBX-UHFFFAOYSA-N
InChI:
InChI=1S/C27H33NO4/c1-4-5-19-6-7-22(26(12-19)31-3)17-32-24-10-11-25-18(2)21(9-8-20(25)13-24)14-28-15-23(16-28)27(29)30/h6-7,10-13,23H,4-5,8-9,14-17H2,1-3H3,(H,29,30)
Canonical SMILES:
CCCC1=CC(=C(C=C1)COC2=CC3=C(C=C2)C(=C(CC3)CN4CC(C4)C(=O)O)C)OC
Current Developer:
Merck KGaA, Ono
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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