|Description||Cenerimod is an active Lysosphingolipid receptor agonist originated by Actelion Pharmaceuticals and EC50 value is 2.7 nM. It is a S1P1/EDG1 receptor agonist and has a long-lasting immunomodulating effect through reducing the number of circulating and infiltrating T- and B-lymphocytes, without affecting their maturation, memory, or expansion. Cenerimod is in phase I/II clinical trials for the treatment of Systemic lupus erythematosus.|
|Solubility||Soluble in DMSO|
|Application||Systemic lupus erythematosus|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Current Developer||Originator：Actelion Pharmaceuticals|
Antennapedia Peptide, a cell-penetrating 16 amino acid peptide originally derived from the 60 amino acid long homeodomain of the Drosophila transcription factor...
TP 472N is a negative control for TP 472. TP 472N is inactive against other bromodomains (>20 μM against BRD9).
LL-37 is a cationic and α-helical antimicrobial peptide. It can inhibit growth of Gram-positive E. coli D21 and Gram-negative B. megatarium in a concentration-d...
Carnosic acid has medicinal properties, is a potent antioxidant and protects skin cells against UV-A radiation (photoprotection). Studies in animals have also f...
Racecadotril is a peripherally acting enkephalinase inhibitor with an IC50 of 4.5 μM.
Pramlintide, a synthetic version of amylin, is the first in a new class of pharmaceutical agents and exhibits high affinity for amylin, CGRP and calcitonin rece...
Acetylaconitine is a diterpenoid alkaloid isolated from the roots of Aconitum kusnezoffii Reichb. It is used in analgesia in rats for the treatment of chronic p...
OKT3-induced PBMC proliferation was inhibited by octahydrocurcumin with IC50 of 82 uM. The investigated substances with the strongest effect on radical scavengi...
MK 0434 is a Cholestenone 5-alpha reductase inhibitor originated by Merck & Co and it is associated with a significant reduction in dihydrotestosterone. No deve...
HMN-154, a novel benzenesulfonamide anticancer drug, inhibits KB (IC50= 0.0026 μg/mL) and colon38 cells (IC50= 0.003 μg/mL).
Cyclophosphamide Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA. It is used to treat cancers and aut...
Carboxy-PTIO, potassium salt
The potassium salt form of Carboxy-PTIO, which is a water soluble, stable organic free radical that could react stoichiometrically with NO.
UK‑396082 is an activated thrombin activatable fibrinolysis inhibitor(Ki = 10 nM), exhibited antithrombotic efficacy in a rabbit model of venous thrombosis, yet...
Ac-DEVD-pNA is a colorimetric substrate for caspase-3 (CPP32) (Km=9.7μM) and related cysteine proteases.
D-erythro-Sphingosine is a natural isomer of sphingosine and acts as an inhibitor of protein kinase C and calmodulin-dependent enzymes with no effects on protei...
Norleual, an angiotensin IV analog, competitively inhibited the binding of HGF to its receptor c-Met in mouse liver membranes. It is also an AT4 receptor antago...
DIBA, a benzamide derivative, has been found to be an ER zinc finger inhibitor that could be significant in studies of breast cancers.
FQI 1 is a cell-permeable and reversible inhibitor of α-globin transcription factor CP2 (LSF; IC50 = 2.1 μM) and an antiproliferative. FQI 1 induces apoptosis i...
PD 130908 is an effective hypoxic cytotoxin as an analogue of RSU 1069, but less potent than the hypoxic cell radiosensitizer RSU 1069. Toxicity toward hypoxic ...
Erlosiban, an iminopyrrolidin derivative, has been found to be a nonpeptide oxytocin receptor antagonist that could probably be used in the treatment of female ...