|Description||Celikalim is s ATP-sensitive potassium channel agonist originated by Wyeth. It increases K+ outward flux in dog and human airway smooth muscle. But clinical trials for Hypertension, Ischaemic heart disorders and Thrombosis was discontinued.|
|Solubility||Soluble in DMSO|
|Application||Hypertension; Ischaemic heart disorders; Thrombosis|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Current Developer||Originator: Wyeth|
PD 118057 is a human ether-a-go-go (hERG) KV11.1 potassium channel activator, with no major effect on INa, ICa/L, IK1 and IKs currents. PD-118057prevents and re...
Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM.
VU 590 dihydrochloride
VU 590 dihydrochloride is a selective renal outer medullary potassium channel (Kir1.1, ROMK) inhibitor (IC50 = 294 nM). VU 590 displays no effect upon Kir2.1 or...
BDS I is a reversible Kv3.4 potassium channel blocker (IC50 = 47 nM) and Nav1.7 channel agonist. BDS I potentiates TTX-sensitive sodium currents in rat small do...
LevCromakalim is an ATP-sensitive K+channel(KATP) activator used in the management of hypertension in diabetes mellitus.
Halofantrine is a blocker of delayed rectifier potassium current via the inhibition of hERG channel used to treat malaria.
Kv1.3 Channel blocker 42 is a selective potassium channel blocker of Kv1.3 current (IC50 < 50 nM). Kv1.3 channel blocker is promisingly used for the treatment o...
Tifenazoxide is a potent selective KATP channels opener with preference for Kir6.2/SUR1. Studies show that it inhibits glucose stimulated insulin release in vit...
XE 991 dihydrochloride
XE 991 dihydrochloride is a potent and selective blocker of KV7 (KCNQ) voltage-gated potassium channels. XE 991 blocks KV7.2+7.3 (KCNQ2+3) / M-currents (IC50 = ...
DCEBIO is a Ca2+ sensitive K+ channel (SKCa) agonist stimulating Cl- secretion via activation of hKCa3.1 (IK1) potassium channels and activation of an apical Cl...
MK 499, also know as L706000, has been found to be a potassium channel antagonist that has been once studied the activity in the treatment of arrhythmias. The P...
Senicapoc, previously called as ICA 17043, is a is a small organic potent and selective blocker of the Gardos channel which is the calciumactivated potassium ch...
NS6180 is a potent KCa3.1 channel blocker (IC50 values are 9, 14 and 15 nM for rat, human and mouse erythrocyte KCa3.1 channels respectively). NS6180 prevents T...
ML252 is a selective and brain penetrant KCNQ2 inhibitor (Kv7.2; IC50 value 69 nM) used in vivo to study KCNQ2 pharmocology.
AmmTX3 is a peptide that can be isolated from the venom of Androctonus mauretanicus and belongs scorpion toxin of the α-KTX15 subfamily. It is a specific potass...
Flupirtine is a selective neuronal potassium channel opener act as an Analgesic, having substituted pyridine with central analgesic properties.
1-EBIO is an activator of epithelial KCa channels, and it stimulates a large and sustained trans-epithelial Cl- secretory response across T84 monolayers. 1-EBIO...
Y-27152 is a prodrug of the Kir6 (KATP) channel opener Y-26763. It was demonstrated ability to produce long-lasting antihypertensive effects in vivo, with minim...
BMS-191095 is an activators that has selective effects on mitochondrial ATP-sensitive potassium (mitoKATP) channels. in vitro: induces mitochondrial-depolarizat...
BeKm 1 is a potent and selective KV11.1 (hERG) channel blocker.