Ceftriaxone - CAS 73384-59-5
Catalog number:
73384-59-5
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C18H18N8O7S3
Molecular Weight:
554.58
COA:
Inquire
Targets:
Antibacterial
Description:
Ceftriaxone is an antibiotic useful for the treatment of a number of bacterial infections. It inhibits bacterial cell wall synthesis by means of binding to the penicillin-binding proteins (PBPs) and has potential to manipulate glutamate transmission and ameliorate neurotoxicity.
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Purity:
>98%
Synonyms:
Rocephin
MSDS:
Inquire
1.Synthetic cathinone MDPV downregulates glutamate transporter subtype I (GLT-1) and produces rewarding and locomotor-activating effects that are reduced by a GLT-1 activator.
Gregg RA1, Hicks C1, Nayak SU1, Tallarida CS1, Nucero P1, Reitz AB2, Smith GR2, Rawls SM3. Neuropharmacology. 2016 Apr 13. pii: S0028-3908(16)30154-X. doi: 10.1016/j.neuropharm.2016.04.014. [Epub ahead of print]
Synthetic cathinones produce dysregulation of monoamine systems, but their effects on the glutamate system and the influence of glutamate on behavioral effects related to cathinone abuse are unknown. A principal regulator of glutamate homeostasis is glutamate transporter subtype 1 (GLT-1), an astrocytic protein that clears glutamate from the extracellular space and influences behavioral effects of established psychostimulants. We hypothesized that repeated administration of the synthetic cathinone, MDPV (3,4-methylenedioxypyrovalerone), would affect GLT-1 expression in the corticolimbic circuit, and that a GLT-1 activator (ceftriaxone, CTX) would reduce rewarding and locomotor-stimulant effects of MDPV in rats. GLT-1 protein expression in the nucleus accumbens (NAcc), but not prefrontal cortex (PFC), was decreased following withdrawal (2, 5 and 10 days) from repeated MDPV treatment, but not immediately after the last MDPV injection. CTX (200 mg/kg) pretreatment did not affect acute locomotor activation produced by MDPV (0.
2.Old but not forgotten: Antibiotic allergies in General Medicine (the AGM Study).
Trubiano JA1, Pai Mangalore R2, Baey YW3, Le D2, Graudins LV4, Charles PG2, Johnson DF2, Aung AK4. Med J Aust. 2016 Apr 18;204(7):273.
OBJECTIVES: To determine the nature, prevalence and description accuracy of recorded antibiotic allergy labels (AALs) in a cohort of general medical inpatients, and to assess the feasibility of an oral antibiotic re-challenge study.
3.Azithromycin-resistant Neisseria gonorrhoeae isolates in Guangzhou, China (2009-2013): coevolution with decreased susceptibilities to ceftriaxone and genetic characteristics.
Liang JY1,2, Cao WL1,2, Li XD1,2, Bi C1,2, Yang RD1,2, Liang YH1,2, Li P1,2, Ye XD1,2, Chen XX1,2, Zhang XB3,4. BMC Infect Dis. 2016 Apr 14;16(1):152. doi: 10.1186/s12879-016-1469-3.
BACKGROUND: The recent emergence of azithromycin-resistant (AZM-R) N. gonorrhoeae isolates that have coevolved decreased susceptibility to extended-spectrum cephalosporins has caused great concern. Here we investigated the prevalence of decreased susceptibility to ceftriaxone (CRO(D)) in AZM-R isolates and genetically characterized AZM-R isolates in Guangzhou, China from 2009 to 2013.
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CAS 73384-59-5 Ceftriaxone

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