Ceftaroline fosamil - CAS 400827-46-5
Catalog number: 400827-46-5
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Ceftaroline Fosamil Inner salt-d3 is labelled Ceftaroline Fosamil inner salt (C243970) which is a cephalosporin antibiotic. It is active against methicillin-resistant Staphylococcus aureus (MRSA) and Gram-positive bacteria.
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Teflaro; Zinforo
1.In-use Stability of Ceftaroline Fosamil in Elastomeric Home Infusion Systems and MINI-BAG Plus Containers.
Bhattacharya S, Parekh S, Dedhiya M. Int J Pharm Compd. 2015 Sep-Oct;19(5):432-6.
The objective of this study was to determine in-use stability of ceftaroline fosamil infusion solution of concentrations up to 12 mg/mL in elastomeric home infusion system prefilled with 0.9% Sodium Chloride Injection USP or 5% Dextrose Injection USP and MINI-BAG Plus Container delivery devices prefilled with 0.9% sodium chloride injection. In-use ceftaroline fosamil infusion solution (12 mg/mL) was prepared for elastomeric home infusion systems (Homepump Eclipse, Baxter Intermate, and AccuRx Elastomeric Pump) pre-filled with either 0.9% sodium chloride injection or 5% dextrose; or Baxter MINI-BAG Plus Containers pre-filled with 0.9% Sodium Chloride Injection USP (4 mg/mL to 12 mg/mL ceftaroline fosamil in final solution). The systems were stored refrigerated for 24 hours followed by up to 6 hours of storage at room temperature. Samples were analyzed at various time points for assay and degradation product by a validated stability-indicating high-performance liquid chromatography method.
2.Single and repeated dose pharmacokinetics of ceftaroline in plasma and soft tissues of healthy volunteers for two different dosing regimens of ceftaroline fosamil.
Matzneller P1, Lackner E1, Lagler H2, Wulkersdorfer B1, Österreicher Z1, Zeitlinger M3. Antimicrob Agents Chemother. 2016 Apr 4. pii: AAC.00097-16. [Epub ahead of print]
OBJECTIVES: Ceftaroline fosamil (CPT-F) is currently approved for treatment of complicated skin and soft tissue infections and community-acquired pneumonia at 600 mg twice daily (q12h), but other dosing regimens are under evaluation. To date, very limited data on soft tissue pharmacokinetics (PK) of the active compound ceftaroline (CPT) are available.
3.Ceftaroline fosamil versus ceftriaxone for the treatment of community-acquired pneumonia: individual patient data meta-analysis of randomized controlled trials.
Taboada M1, Melnick D2, Iaconis JP3, Sun F4, Zhong NS5, File TM6, Llorens L7, Friedland HD7, Wilson D8. J Antimicrob Chemother. 2016 Apr;71(4):862-70. doi: 10.1093/jac/dkv415. Epub 2015 Dec 24.
BACKGROUND: We conducted a meta-analysis of clinical trials of adults hospitalized with pneumonia outcomes research team (PORT) risk class 3-4 community-acquired pneumonia (CAP) receiving ceftaroline fosamil versus ceftriaxone.
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