Cefprozil monohydrate - CAS 121123-17-9
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Not Intended for Therapeutic Use. For research use only.
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Cefprozil hydrate (Cefzil) is a second-generation cephalosporin type antibiotic. Cefprozil hydrate (Cefzil) can be used to treat bronchitis, ear infections, skin infections, and other bacterial infections.
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1.Stability indicating methods for the analysis of cefprozil in the presence of its alkaline induced degradation product.
Attia KA1, Nassar MW1, El-Zeiny MB2, Serag A3. Spectrochim Acta A Mol Biomol Spectrosc. 2016 Apr 15;159:1-6. doi: 10.1016/j.saa.2016.01.026. Epub 2016 Jan 21.
Three simple, specific, accurate and precise spectrophotometric methods were developed for the determination of cefprozil (CZ) in the presence of its alkaline induced degradation product (DCZ). The first method was the bivariate method, while the two other multivariate methods were partial least squares (PLS) and spectral residual augmented classical least squares (SRACLS). The multivariate methods were applied with and without variable selection procedure (genetic algorithm GA). These methods were tested by analyzing laboratory prepared mixtures of the above drug with its alkaline induced degradation product and they were applied to its commercial pharmaceutical products.
2.The management of acute mastoiditis in children with cochlear implants: saving the device.
Osborn HA1, Cushing SL, Gordon KA, James AL, Papsin BC. Cochlear Implants Int. 2013 Nov;14(5):252-6. doi: 10.1179/1754762813Y.0000000049. Epub 2013 Aug 30.
OBJECTIVE: Early treatment of profound bilateral sensorineural hearing loss with cochlear implantation has become routine, resulting in an increased proportion of children implanted at younger ages. These children are at a relatively high risk for acute otitis media (AOM), and are more likely to develop mastoiditis in the implanted ear. Despite the significant risks associated with mastoiditis, including compromise of the implant, there are no specific guidelines on the management of this population. We propose a treatment algorithm emphasizing early but conservative operative intervention.
3.The initial state of the human gut microbiome determines its reshaping by antibiotics.
Raymond F1, Ouameur AA1, Déraspe M1, Iqbal N1, Gingras H1, Dridi B1, Leprohon P1, Plante PL1, Giroux R1, Bérubé È1, Frenette J1, Boudreau DK1, Simard JL1, Chabot I1, Domingo MC2, Trottier S1, Boissinot M1, Huletsky A1, Roy PH1, Ouellette M1, Bergeron MG1, ISME J. 2016 Mar;10(3):707-20. doi: 10.1038/ismej.2015.148. Epub 2015 Sep 11.
Microbiome studies have demonstrated the high inter-individual diversity of the gut microbiota. However, how the initial composition of the microbiome affects the impact of antibiotics on microbial communities is relatively unexplored. To specifically address this question, we administered a second-generation cephalosporin, cefprozil, to healthy volunteers. Stool samples gathered before antibiotic exposure, at the end of the treatment and 3 months later were analysed using shotgun metagenomic sequencing. On average, 15 billion nucleotides were sequenced for each sample. We show that standard antibiotic treatment can alter the gut microbiome in a specific, reproducible and predictable manner. The most consistent effect of the antibiotic was the increase of Lachnoclostridium bolteae in 16 out of the 18 cefprozil-exposed participants. Strikingly, we identified a subgroup of participants who were enriched in the opportunistic pathogen Enterobacter cloacae after exposure to the antibiotic, an effect linked to lower initial microbiome diversity and to a Bacteroides enterotype.
4.In Vitro Activity of Oral Cephalosporins (Cefprozil and Cefixime) Against Ciprofloxacin-Resistant Enterobacteriaceae from Community-Acquired Urinary-Tract Infections.
Pistiki A1, Tsaganos T1, Galani I1, Giamarellos-Bourboulis EJ2. Infect Dis Ther. 2015 Dec;4(4):425-32. doi: 10.1007/s40121-015-0089-3. Epub 2015 Sep 21.
INTRODUCTION: The global emergence of pathogens of urinary-tract infections resistant to ciprofloxacin or producing extended-spectrum β-lactamases (ESBL) led us to investigate the activity of older antimicrobials such as cefprozil and cefixime against a recent broad collection of urine enterobacteria from 2012 and 2013.
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CAS 121123-17-9 Cefprozil monohydrate

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