Cefetamet Pivoxil Hydrochloride - CAS 111696-23-2
Catalog number:
111696-23-2
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C20H26ClN5O7S2
Molecular Weight:
548.03
COA:
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Targets:
Antibacterial
Description:
The hydrochloride salt form of Cefetamet pivoxil, one of the third generation cephalosporin antibiotics, could be effective in the treatment for sorts of infections caused by sensitive bacteria.
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Purity:
95%
Appearance:
Powder
Synonyms:
Cefetamet pivoxil hydrochloride; CS-O-14591
Solubility:
10 mM in DMSO
Storage:
-20ºC Freeze
MSDS:
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Application:
The hydrochloride salt form of Cefetamet pivoxil could be effective in the treatment for sorts of infections caused by sensitive bacteria.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
Boiling Point:
732.3ºC at 760 mmHg
InChIKey:
XAAOHMIKXULDKJ-UHFFFAOYSA-N
InChI:
InChI=1S/C20H25N5O7S2.ClH/c1-9-6-33-16-12(23-14(26)11(24-30-5)10-7-34-19(21)22-10)15(27)25(16)13(9)17(28)31-8-32-18(29)20(2,3)4;/h7,12,16H,6,8H2,1-5H3,(H2,21,22)(H,23,26);1H
Canonical SMILES:
CC1=C(N2C(C(C2=O)NC(=O)C(=NOC)C3=CSC(=N3)N)SC1)C(=O)OCOC(=O)C(C)(C)C.Cl
1.Kinetics of degradation of cefetamet pivaloyloxymethyl ester and its hydrochloride in solid phase.
Jelińska A1, Zajac M, Dobrowolski L, Medenecka B, Ruciński P, Oszczapowicz I. Acta Pol Pharm. 2003 Nov-Dec;60(6):435-41.
The influence of temperature and relative humidity on the stability of cefetamet pivoxil (CFP) and its hydrochloride (CFP.HCl) in solid phase was investigated. The process of degradation was studied using HPLC with UV detection. The degradation of CFP and CFP.HCl occurring at air humidity RH>50% is an autocatalytic first-order reaction with respect to substrate concentration, while at 0% relative humidity of the ambient air it is a first-order reaction relative to substrate concentration for CFP.HCl, and a reversible first-order reaction for CFP. The rate constants (k) were determined in dry air at 373 K, 378 K, 383 K, 388 K and 393 K; at air humidity RH = 76.4% at 333 K, .343 K, 353 K, 363 K and 373 K; and at 363 K at air humidity RH>50%. The kinetic and thermodynamic parameters of the degradation were calculated.
2.Spectrophotometric Determination of Cefetamet Pivoxil Hydrochloride and Pitavastatin Calcium in Tablet Dosage form.
Vadia NH1, Patel V, Bhalara HN. Indian J Pharm Sci. 2008 Sep;70(5):649-51. doi: 10.4103/0250-474X.45408.
Two simple, rapid, specific and accurate analytical methods for the estimation of cefetamet pivoxil hydrochloride and pitavastatin calcium in bulk drug and in their tablet formulations are described. These methods are based on difference spectrophotometry, wherein the measurement is done at maximum 221 nm and minimum 275 nm for cefetamet whereas at maximum 240 nm and minimum 259 nm for pitavastatin. The Beer's law was obeyed in the concentration range of 1-35 μg/ml and 1-25 μg/ml and the molar absorptivities were 1.3×10(4) lit mol(-1) cm(-1) and 2.4×10(4) lit mol(-1) cm(-1) for cefetamet pivoxil hydrochloride and pitavastatin calcium, respectively. The proposed methods were validated and successfully applied to the estimation of drugs in tablet formulations.
3.LC method for the analysis of cefetamet pivoxil hydrochloride in drug substance and powder for oral suspension.
Morsch LM1, Bittencourt CF, e Souza MJ, Milano J. J Pharm Biomed Anal. 2002 Oct 15;30(3):643-49.
A high-performance liquid chromatography isocratic procedure was developed for the assay of cefetamet pivoxil hydrochloride in drug substance and powder for oral suspension. The method validation yielded good results and included the range, linearity, precision intra- inter-day, accuracy, specificity, LOD and LOQ values. The chromatographic system consisted of a C(18) absorbosphere column (150 x 4.6 mm i.d., 5 microm particle size), a mobile phase composed of water-acetonitrile-methanol-phosphate buffer, pH 3.5 (50:35:10:5, v/v), flow rate of 1.5 ml min(-1) and UV detection at 254 nm. The relative standard deviation varied between 0.03 and 1.76%, and accuracy of 100.09% was found. Calibration curve was linear from 30.0-80.0 microg ml(-1); its correlation coefficient was 0.99989.
4.The influence of pH, temperature and buffers on the degradation kinetics of cefetamet pivoxil hydrochloride in aqueous solutions.
Jelińska A1, Dobrowolski L, Oszczapowicz I. J Pharm Biomed Anal. 2004 Sep 3;35(5):1273-7.
The first-order hydrolysis kinetics of cefetamet pivoxil (CP) were investigated as a function of pH, temperature and buffers. The degradation was followed by HPLC. Buffer catalysis was observed in acetate and phosphate buffers. The pH-rate profiles for hydrolysis of cefetamet pivoxil were obtained at 333, 343, 353 and 363K. The pH-rate expression was k(pH)=kH+aH+ + kH2OkOH-aOH-, where kH+ and kOH- are the second-order rate constants (mol(-1)ls(-1)) for hydrogen ion activity and for hydroxyl ion activity respectively, and kH2O is the pseudo-first-order rate constant (s(-1)) for spontaneous reaction under the influence of water. The pH-rate profile was characteristically U-shaped. Maximum stability was observed in the pH region from 3 to 5.
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CAS 111696-23-2 Cefetamet Pivoxil Hydrochloride

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