Cefditoren Pivoxil - CAS 117467-28-4
Catalog number:
117467-28-4
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C25H28N6O7S3
Molecular Weight:
620.72
COA:
Inquire
Targets:
Antibacterial
Description:
Cefditoren possesses a broad-spectrum of cidal antibacterial activity against both Gram-positive and Gram-negative species with stability to many beta-lactamases of clinical importance。
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
ME-1207
MSDS:
Inquire
1.Application of silver nanoparticles to the chemiluminescence determination of cefditoren pivoxil using the luminol-ferricyanide system.
Alarfaj NA1, Aly FA, El-Tohamy MF. Luminescence. 2015 Feb;30(1):91-7. doi: 10.1002/bio.2696. Epub 2014 May 22.
A new simple, accurate and sensitive sequential injection analysis chemiluminescence (CL) detection method for the determination of cefditoren pivoxil (CTP) has been developed. The developed method was based on the enhancement effect of silver nanoparticles on the CL signal arising from a luminol-potassium ferricyanide reaction in the presence of CTP. The optimum conditions relevant to the effect of luminol, potassium ferricyanide and silver nanoparticle concentrations were investigated. The proposed method showed linear relationships between relative CL intensity and the investigated drug concentration at the range 0.001-5000 ng/mL, (r = 0.9998, n = 12) with a detection limit of 0.5 pg/mL and quantification limit of 0.001 ng/mL. The relative standard deviation was 1.6%. The proposed method was employed for the determination of CTP in bulk drug, in its pharmaceutical dosage forms and biological fluids such as human serum and urine. The interference of some common additive compounds such as glucose, lactose, starch, talc and magnesium stearate was investigated.
2.Population data analysis of dissolution time profiles: Assessment of physicochemical properties of the drug, drug particles and the pharmaceutical formulation.
Horkovics-Kovats S1, Brunovský P2, Pichler A3, Bulitta JB4. Eur J Pharm Sci. 2015 Oct 12;78:245-54. doi: 10.1016/j.ejps.2015.07.017. Epub 2015 Jul 26.
Disintegration of finished dosage forms (FDF) and drug dissolution are fundamentally important processes that affect bioavailability. Established theories do not account for disintegration and usually assume sink conditions for drug dissolution that often do not apply. We present the theory to describe the disintegration of FDF with subsequent dissolution of liberated particles containing the active pharmaceutical ingredient (API) and its application using population data analysis. Population modeling, using dissolution profiles of 400mg cefditoren pivoxil tablets manufactured under various tableting pressures, characterized the intrinsic lifetime distribution of the particles and identified the presence of crystalline API in the formulation that was proven by X-ray diffraction. Modeling further estimated the disintegration time of FDF, the solubility of the amorphous API and its chemical instability in the medium that were in agreement with the experimentally determined values.
3.Preparation and characterization of cefditoren pivoxil-loaded liposomes for controlled in vitro and in vivo drug release.
Venugopalarao G1, Lakshmipathy R2, Sarada NC1. Int J Nanomedicine. 2015 Oct 1;10 Suppl 1:149-57. doi: 10.2147/IJN.S79994. eCollection 2015.
BACKGROUND: The application of antibiotics has been limited due to weak biodistribution and pharmacokinetics. Encapsulation of these drugs in lipid vesicles might be a good solution for obtaining the required properties. Liposomes are one of the most suitable drug-delivery systems to deliver the drug to the target organ and minimize the distribution of the drug to non-target tissues.
4.A Comparison of Cefditoren Pivoxil 8-12 mg/kg/day and Cefditoren Pivoxil 16-20 mg/kg/day in Treatment of Children With Acute Presumed Bacteri
Poachanukoon O1, Tangsathapornpong A2, Tanuchit S3. Clin Exp Otorhinolaryngol. 2015 Jun;8(2):129-35. doi: 10.3342/ceo.2015.8.2.129. Epub 2015 May 13.
OBJECTIVES: Cefditoren pivoxil (CDT) has been used in the treatment of rhinosinusitis. However, little is known about the efficacy of this drug at low and high doses. This study was to compare the efficacy and safety of low dose (8-12 mg/kg/day) and high dose (16-20 mg/kg/day) CDT in the treatment of children with uncomplicated acute rhinosinusitis (ARS).
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Antibacterial Products


CAS 78439-06-2 Ceftazidime Pentahydrate

Ceftazidime Pentahydrate
(CAS: 78439-06-2)

Ceftazidime is an antibiotic useful for the treatment of bacterial infections. It is can be used for joint infections, meningitis, pneumonia, sepsis, urinary tr...

CAS 23325-78-2 Cephalexin monohydrate

Cephalexin monohydrate
(CAS: 23325-78-2)

A semisynthetic cephalorsporin antibiotic.

CAS 122-11-2 Sulphadimethoxine

Sulphadimethoxine
(CAS: 122-11-2)

Sulphadimethoxine is a non-reducing glucuronide.

CAS 72558-82-8 Ceftazidime

Ceftazidime
(CAS: 72558-82-8)

Ceftazidime is an antibiotic useful for the treatment of a number of bacterial infections. It is a third-generation cephalosporin, but it is not used to treat v...

CAS 1672-88-4 Furagin

Furagin
(CAS: 1672-88-4)

Furagin (a nitrofurantoin analog) has the same efficacy in treating acute cystitis as Ciprofloxacin, however the duration of therapy is longer. Antibacterial.

CAS 26309-95-5 Pivampicillin Hydrochloride

Pivampicillin Hydrochloride
(CAS: 26309-95-5)

Pivampicillin, an ester that hydrolyzes to ampicillin in vivo, is a semi-synthetic antibiotic.

CAS 59695-59-9 Cephalexin hydrochloride

Cephalexin hydrochloride
(CAS: 59695-59-9)

Cefalexin hydrochloride is a cephalosporin antibiotic. It is a first-generation cephalosporin antibiotic introduced in 1967 by Eli Lilly and Company. It is an o...

CAS 112811-59-3 Gatifloxacin

Gatifloxacin
(CAS: 112811-59-3)

Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, and inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.

CAS 114-07-8 Erythromycin

Erythromycin
(CAS: 114-07-8)

Erythromycin is a macrolide antibiotic that has an antimicrobial spectrum similar to or slightly wider than that of penicillin (IC50=1.5 μg/ml).

CAS 79660-72-3 Fleroxacin

Fleroxacin
(CAS: 79660-72-3)

Fleroxacin is a bactericidal drug that inhibits bacterial DNA gyrase and topoisomerase IV. Like other quinolones and fluoroquinolones, it eradicates bacteria by...

CAS 25389-94-0 Kanamycin sulfate

Kanamycin sulfate
(CAS: 25389-94-0)

Antibiotic. Inhibits translocation during protein biosynthesis

CAS 1431699-67-0 (S)-Tedizolid

(S)-Tedizolid
(CAS: 1431699-67-0)

Antibacterial oxazolidinone against gram-positive species

CAS 1220-83-3 Sulfamonomethoxine

Sulfamonomethoxine
(CAS: 1220-83-3)

Sulfamonomethoxine, a sulfonamide derivative, is an antibacterial agent commonly used as a veterinary drug.

CAS 127045-41-4 Pazufloxacin

Pazufloxacin
(CAS: 127045-41-4)

Pazufloxacin (T-3761), a new quinolone derivative, showed broad and potent antibacterial activity. T-3761 showed good efficacy in mice against systemic, pulmona...

CAS 147-52-4 Nafcillin

Nafcillin
(CAS: 147-52-4)

Nafcillin, a semi-synthetic penicillin analogue, has been found to be an antibiotic that could be effective especially against Gram-positive bacteria.

CAS 70458-92-3 Pefloxacin

Pefloxacin
(CAS: 70458-92-3)

Pefloxacin is a an antibacterial agent and prevents bacterial DNA replication by inhibiting DNA gyrase. It is a synthetic chemotherapeutic agent used to treat s...

CAS 56-75-7 Chloramphenicol

Chloramphenicol
(CAS: 56-75-7)

Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections.

CAS 91832-40-5 Cefdinir

Cefdinir
(CAS: 91832-40-5)

Cefdinir is a semi-synthetic, broad-spectrum antibiotic, used for soft tissue infections and respiratory tract infections

CAS 163253-35-8 Sitafloxacin Hydrate

Sitafloxacin Hydrate
(CAS: 163253-35-8)

Sitafloxacin is active against methicillin-resistant staphylococci, Streptococcus pneumoniae and other streptococci with reduced susceptibility to levofloxacin ...

CAS 426253-04-5 Razupenem

Razupenem
(CAS: 426253-04-5)

Razupenem is an injectable, 1β-methylcarbapenem antibacterial performed well against a variety of bacterial strains.

Chemical Structure

CAS 117467-28-4 Cefditoren Pivoxil

Quick Inquiry

Verification code

Featured Items