Cefamandole nafate - CAS 42540-40-9
Catalog number:
42540-40-9
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C19H17N6NaO6S2
Molecular Weight:
512.49
COA:
Inquire
Targets:
Antibacterial
Description:
Cefamandole nafate is the formate ester cefamandole, as a broad-spectrum cephalosporin antibiotic
Publictions citing BOC Sciences Products
  • >> More
Purity:
≥95%
Appearance:
White solid
Synonyms:
(6R,7R)-7-[[(2R)-2-(Formyloxy)-2-phenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Sodium Salt;
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
Cephalosporin antibiotic
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
Melting Point:
190-193 ºC
InChIKey:
ICZOIXFFVKYXOM-YCLOEFEOSA-M
InChI:
1S/C19H18N6O6S2.Na/c1-24-19(21-22-23-24)33-8-11-7-32-17-12(16(28)25(17)13(11)18(29)30)20-15(27)14(31-9-26)10-5-3-2-4-6-10;/h2-6,9,12,14,17H,7-8H2,1H3,(H,20,27)(H,29,30);/q;+1/p-1/t12-,14-,17-;/m1./s1
Canonical SMILES:
CN1C(=NN=N1)SCC2=C(N3C(C(C3=O)NC(=O)C(C4=CC=CC=C4)OC=O)SC2)C(=O)[O-].[Na+]
Current Developer:
Eli Lilly Canada Inc
1.Synergistic activity of dispersin B and cefamandole nafate in inhibition of staphylococcal biofilm growth on polyurethanes.
Donelli G1, Francolini I, Romoli D, Guaglianone E, Piozzi A, Ragunath C, Kaplan JB. Antimicrob Agents Chemother. 2007 Aug;51(8):2733-40. Epub 2007 Jun 4.
Antibiotic therapies to eradicate medical device-associated infections often fail because of the ability of sessile bacteria, encased in their exopolysaccharide matrix, to be more drug resistant than planktonic organisms. In the last two decades, several strategies to prevent microbial adhesion and biofilm formation on the surfaces of medical devices, based mainly on the use of antiadhesive, antiseptic, and antibiotic coatings on polymer surfaces, have been developed. More recent alternative approaches are based on molecules able to interfere with quorum-sensing phenomena or to dissolve biofilms. Interestingly, a newly purified beta-N-acetylglucosaminidase, dispersin B, produced by the gram-negative periodontal pathogen Actinobacillus actinomycetemcomitans, is able to dissolve mature biofilms produced by Staphylococcus epidermidis as well as some other bacterial species. Therefore, in this study, we developed new polymeric matrices able to bind dispersin B either alone or in combination with an antibiotic molecule, cefamandole nafate (CEF).
2.Estimation of the two sample preparation techniques for infrared spectroscopic identification of Cefamandole nafate in solid state.
Kalinkova GN1, Opalchenova G. Pharmeur Sci Notes. 2007 Sep;2007(1):9-13.
The European Pharmacopoeia (Ph.Eur.) monograph for Cefamandole Nafate (CFN) and the revised monograph prescribe the identification of the antibiotic in solid state by infrared (IR) absorption spectrophotometry using potassium bromide (KBr) disc technique. But, this technique may cause unwanted solid-solid transformations in the crystalline structure of the beta-lactam antibiotic CFN. The latter is a drug with proven polymorphism/pseudopolymorphism. In this context we have examined the suitability of the two techniques (KBr disc and Nujol mull) for IR spectral analyses to identify the antibiotic CFN in solid state. The results of our examinations show that KBr disc technique alters the crystalline state of CFN during the preparation of its KBr disc samples by the tribomechanical treatments (grinding and compression pressure). On the contrary, the Nujol mull technique does not cause such transformations and it is estimated as a better, more suitable technique to be employed for identification of CFN.
3.Kinetics of cefamandole nafate degradation in solid phase.
Jelińska A1, Zajac M, Gostomska J, Szczepaniak M. Farmaco. 2003 Apr;58(4):309-13.
The influence of temperature and relative humidity (RH) on the stability of cefamandole (CM) nafate sodium in the solid phase was investigated. Changes in the concentration of cefemandole nafate sodium were recorded using HPLC with UV detection. The method was validated for the following parameters: selectivity, linearity, precision, limit of detection and sensitivity. It showed good linearity (r=0.9996) in the range 0.4 x 10(-4)-5.6 x 10(-4) g ml(-1) using a LiChrospher RP-18 column and as mobile phase acetonitryle-triethylamine (10% v/v, adjusted to pH 2.5 with phosphoric acid (84%) and diluted with water) (35:65). The degradation of CM occurring at 0% RH of the ambient air and at air humidity RH>50% is a first-order reaction relative to substrate concentration. The first-order rate constants (k) were determined for CM degradation in dry air at 373, 383, 388 and 393 K, at air humidity RH=76.4% at 323, 333, 343 and 353 K, and at 353 K at air humidity RH>50%.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Antibacterial Products


CAS 117467-28-4 Cefditoren Pivoxil

Cefditoren Pivoxil
(CAS: 117467-28-4)

Cefditoren possesses a broad-spectrum of cidal antibacterial activity against both Gram-positive and Gram-negative species with stability to many beta-lactamase...

NITD-304
(CAS: 1473450-60-0)

NITD-304, an indole derivative, has been found to be an antitubercular agent that could be effective through influencing multidrug-resistant mycobacterium tuber...

CAS 52-51-7 Bronopol

Bronopol
(CAS: 52-51-7)

Bronopol is an organic compound that is used as an antimicrobial with low mammalian toxicity and high activity.

Alatrofloxacin Mesylate
(CAS: 157605-25-9)

The mesylate salt form of alatrofloxacin, a fluoroquinolone derivative, has been found to be a Type II DNA topoisomerase inhibitor that was once developed to be...

CAS 74610-55-2 Tylosin tartrate

Tylosin tartrate
(CAS: 74610-55-2)

Tylosin tartrate is a macrolide antibiotic approved for the control of mycoplasmosis in poultry.

CAS 148717-90-2 Squalamine

Squalamine
(CAS: 148717-90-2)

Squalamine is a naturally derived broad-spectrum antibiotic that is predominantly derived from the livers of dogfish and other shark species. Squalamine is unde...

CAS 105956-97-6 Clinafloxacin

Clinafloxacin
(CAS: 105956-97-6)

Clinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category currently in development for intravenous and oral therapy of serious infe...

CAS 316819-28-0 Gatifloxacin mesylate

Gatifloxacin mesylate
(CAS: 316819-28-0)

Gatifloxacin (mesylate) is an antibiotic of the fourth-generation fluoroquinolone family, it inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.

CAS 426253-04-5 Razupenem

Razupenem
(CAS: 426253-04-5)

Razupenem is an injectable, 1β-methylcarbapenem antibacterial performed well against a variety of bacterial strains.

CAS 4146-30-9 Framycetin sulphate

Framycetin sulphate
(CAS: 4146-30-9)

Neomycin is an aminoglycoside antibiotic found in many topical medications such as creams, ointments, and eyedrops. Neomycin belongs to aminoglycoside class of ...

CAS 651-06-9 Sulfameter

Sulfameter
(CAS: 651-06-9)

Sulfameter is a long-acting sulfonamide antibacterial. It is used as a leprostatic agent and in the treatment of urinary tract infections.

CAS 66309-69-1 Cefotiam Dihydrochloride

Cefotiam Dihydrochloride
(CAS: 66309-69-1)

Cefotiam hydrochloride is a third generation beta-lactam cephalosporin antibiotic for treatment of severe infections caused by susceptible bacteria.

CAS 68373-14-8 Sulbactam

Sulbactam
(CAS: 68373-14-8)

Sulbactam is a β-lactamase inhibitor. This drug is given in combination with β-lactam antibiotics to inhibit β-lactamase, an enzyme produced by bacteria that de...

CAS 4008-48-4 Nitroxoline

Nitroxoline
(CAS: 4008-48-4)

Nitroxoline is a urinary antibacterial agent had proven to be very effective at combating biofilm infections.

CAS 26787-78-0 Amoxicillin

Amoxicillin
(CAS: 26787-78-0)

Amoxicillin is a moderate-spectrum, bacteriolytic, β-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. It is usually th...

CAS 14222-60-7 Prothionamide

Prothionamide
(CAS: 14222-60-7)

An anti-tuberculosis agent. It has also been used to treat Leprosy. Antibacterial (tuberculostatic).

CAS 74849-93-7 Cefpiramide sodium

Cefpiramide sodium
(CAS: 74849-93-7)

Cefpiramide sodium is a new Pseudomonas-active cephalosporin with a broad spectrum of antibacterial activity. It was more active against Acinetobacter spp. and ...

CAS 4697-14-7 Ticarcillin disodium

Ticarcillin disodium
(CAS: 4697-14-7)

Ticarcillin disodium a carboxypenicillin used to prevent cross-linking of peptidoglycan during cell wall synthesis, when the bacteria try to divide, causing cel...

CAS 123171-59-5 Cefepime Dihydrochloride Monohydrate

Cefepime Dihydrochloride Monohydrate
(CAS: 123171-59-5)

Cefepime is an extended-spectrum parenteral cephalosporin antibiotic active in vitro against a broad spectrum of gram-positive and gram-negative aerobic bacteri...

CAS 27164-46-1 Cefazolin sodium

Cefazolin sodium
(CAS: 27164-46-1)

Cefazolin sodium, derived from 7-amino-cephalosporanic acid, is a semi-synthetic, first-generation cephalosporin antibiotic.

Chemical Structure

CAS 42540-40-9 Cefamandole nafate

Quick Inquiry

Verification code

Featured Items