CD1530 - CAS 107430-66-0
Catalog number: 107430-66-0
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C27H26O3
Molecular Weight:
398.49
COA:
Inquire
Targets:
RAR/RXR
Description:
CD1530 is a potent and selective retinoic acid receptor(RAR) agonist with Ki values of 150, 1500 and 2750 nM for RARγ, RARβ and RARα receptors respectively. It was also a potent CYP26A1 inhibitor as ketoconazole with an IC50 value of 530 nM. It inhibited excessive ROS production in tongue epithelial cells in vitro. It demonstrates transcriptional activity at RARγ with an AC50 value of 1.8 nM. It has been shown to preserve human tendon stem cell characteristics, promote repair of injured skeletal muscle, and in combination with bexarotene to inhibit oral carcinogenesis.
Purity:
>98 %
Appearance:
Off-white solid
Synonyms:
4-(6-Hydroxy-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl)benzoicacid; CD1530; CD 1530; CD-1530.4-(7-((3R,5R,7R)-adamantan-1-yl)-6-hydroxynaphthalen-2-yl)benzoic acid;4-[7-(1-Adamantyl)-6-hydroxynaphthalen-2-yl]benzoic acid
Solubility:
Soluble to 50 mM in 1eq. NaOH,DMSO: soluble20 mg/mL, clear
Storage:
2-8°C
MSDS:
Inquire
Application:
CD1530 has been shown to preserve human tendon stem cell characteristics, promote repair of injured skeletal muscle, and in combination with bexarotene to inhibit oral carcinogenesis.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Boiling Point:
610.7±55.0 °C | Condition: Press: 760 Torr
Density:
1.290±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
VCQGNUWOMLYNNG-UHFFFAOYSA-N
InChI:
InChI=1S/C27H26O3/c28-25-12-22-6-5-21(19-1-3-20(4-2-19)26(29)30)10-23(22)11-24(25)27-13-16-7-17(14-27)9-18(8-16)15-27/h1-6,10-12,16-18,28H,7-9,13-15H2,(H,29,30)
Canonical SMILES:
C1C2CC3CC1CC(C2)(C3)C4=C(C=C5C=CC(=CC5=C4)C6=CC=C(C=C6)C(=O)O)O
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