CCT251545 - CAS 1661839-45-7
Catalog number: 1661839-45-7
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C23H24ClN5O
Molecular Weight:
421.92
COA:
Inquire
Targets:
Wnt
Description:
CCT251545, a small molecule inhibitor of WNT signaling with oral activity, can be used as a selective chemical probe that exhibits >100-fold selectivity for the human Mediator complex–associated protein kinases CDK8 and CDK19 over 291 other kinases. IC50:
Appearance:
Solid powder
Synonyms:
8-[3-chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneCCT251545; CCT 251545; CCT-251545; CHEMBL34082138-(3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one8-{3-Chloro-5-[4-(1-Methyl-1h-Pyrazol-4-Yl)ph
Solubility:
DMSO: ≥ 50 mg/mL
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -64℃ for long term (months to years).
MSDS:
Inquire
Shelf Life:
2 years
Quantity:
Grams-Kilos
Boiling Point:
709.7±60.0 °C | Condition: Press: 760 Torr
Density:
1.37±0.1 g/cm3
InChIKey:
LBFYQISQYCGDDW-UHFFFAOYSA-N
InChI:
1S/C23H24ClN5O/c1-28-15-18(12-27-28)16-2-4-17(5-3-16)19-13-25-14-20(24)21(19)29-10-7-23(8-11-29)6-9-26-22(23)30/h2-5,12-15H,6-11H2,1H3,(H,26,30)
Canonical SMILES:
CN1C=C(C=N1)C2=CC=C(C=C2)C3=CN=CC(=C3N4CCC5(CCNC5=O)CC4)Cl
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Wnt Products


CAS 1118807-13-8 KY02111

KY02111
(CAS: 1118807-13-8)

KY02111 promotes differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, may act downstream of APC and GSK3β.

CAS 909089-13-0 SKL 2001

SKL 2001
(CAS: 909089-13-0)

SKL 2001 is a Wnt/β-catenin signaling pathway agonist that modulates the differentiation of mesenchumal stem cells. It upregulates the β-catenin responsive tran...

CAS 853220-52-7 BML-284

BML-284
(CAS: 853220-52-7)

BML-284 is potent selective, and cell-permeable Wnt signaling activator that does not inhibit GSK-3β (IC50 > 60 µM). It appears to mimic the effects of a Wnt li...

CAS 1956356-56-1 KYA1797K

KYA1797K
(CAS: 1956356-56-1)

KYA1797K is a potent, selective and dual inhibitor of Wnt/β-catenin (IC50= 0.75 µM) that significantly decreases reporter activities for the Wnt/β-catenin and M...

CAS 838818-26-1 WIKI4

WIKI4
(CAS: 838818-26-1)

WIKI4 is a novel inhibitor of tankyrase and Wnt/ß-catenin signaling. WIKI4 inhibits expression of ß-catenin target genes and cellular responses to Wnt/ß-catenin...

CAS 664969-54-4 LF3

LF3
(CAS: 664969-54-4)

LF3 is a potent inhibitor of Wnt/β-catenin signaling (IC50= 1.65 μM), but does not interfere with E-cadherin/β-catenin-mediated cell-cell adhesion.antitumor act...

CAS 1792999-26-8 NCB-0846

NCB-0846
(CAS: 1792999-26-8)

NCB-0846 is an orally available, first-in-class TNIK inhibitor (IC50= 21 nM) and shows marked anti-tumour and anti-CSC activities.

CAS 442644-28-2 JW 67

JW 67
(CAS: 442644-28-2)

JW 67 has been found to be a new antagonist of canonical Wnt signaling and exhibit activities in restraining growth and downregulated Wnt target genes in human ...

Quick Inquiry

Verification code

Featured Items