|Description||cCMP-AM is a membrane-permeant and metabolically activatable prodrug of cCMP, the potential further second messenger. cCMP is released after permeation and metabolism of cCMP-AM by esterases, which is trapped inside the cell and metabolized to result in a pulse-type signal.|
|Purity||≥ 95% by HPLC|
|Synonyms||Cytidine- 3', 5'- cyclic monophosphate, acetoxymethyl ester|
Rp-8-Br-cGMPS is an inhibitor of protein kinase G I α and I ß. It effects against mammalian cyclic nucleotide- dependent phosphodiesterases. Compared to cGMP or...
6-AE-cAMP is often used as a ligand for affinity chromatography of cAMP and cGMP binding proteins.
8-pHPT-2'-O-Me-cAMP is an activator of the exchange protein activated by cAMP (Epac) or cAMP-GEF, which does not activate protein kinase A. It has superior lipo...
2'-O-MB-cAMP is a precursor of cAMP. cAMP and butyrate are released after the metabolism of 2'-O-MB-cAMP by esterases.
Sp-c-diGMPS is an analogue of c-diGMP, the bacterial second messenger, which can be used to study ligand-receptor interactions.
2'-TAMRA-AEC-cGMP is a fluorescent cGMP analogue (λexc555 nm, λem580 nm) that can be used for phosphodiesterase studies.
8-AET-2'-O-Me-cAMP-Agarose is the second messenger cAMP with a methylated ribose 2'-hydroxyl group immobilized on agarose by an aminoethylthio spacer, which can...
2'd-7-CH-ATP is an isosteric modification of dATP.
c[G(2',5')pA(3',5')p] / 2'3'-cGAMP
c[G(2',5')pA(3',5')p] was considered to be the metazoan second messenger which is produced by cGAMP synthase (cGAS), the mammalian intrinsic immune DNA sensor. ...
8-OH-cAMP is a polar analogue of cAMP used for the study of extracellular cAMP receptors. When applied by patch clamp techniques, 8-OH-cAMP remains trapped insi...
Sp-5,6-DCl-cBIMPS is a selective stimulator of cAMP- dependent protein kinases preferrring site B of type II isozyme. It is superior to dibutyryl cAMP or 8-CPT-...
8-AET-cGMP-Agarose is the second messenger cGMP immobilized on agarose by an aminoethylthio spacer, which can be used in affinity chromatography of cyclic nucle...
Sp-8-Br-cAMPS-AM is a PDE-resistant precursor of Sp-8-Br-cAMPS, the protein kinase A stimulator. The active analogue is released after the metabolism of Sp-8-Br...
Rp-cCMPS is a PDE-resistant cCMP, the potential second messenger, which inhibits cCMP-binding proteins.
8-AEA-cAMP is a ligand for affinity chromatography of cAMP and cGMP binding proteins. It can be modified with fluorophores and other markers.
Rp-8-CPT-cAMPS is an analog of Rp-cAMPS and a competitive inhibitor of protein kinase A type I and II (cAMP antagonist). It effects against mammalian cyclic nuc...
c[8-AET-G(2',5')pA(3',5')p] is an analogue of c[G(2',5')pA(3',5')p], the metazoan cyclic dinucleotide second messenger and STING activator, which is used as a l...
8-Br-2'-O-Me-cGMP is an analogue of cGMP that does not activate both protein kinase G and Epac. It is often used as an inactive control versus 8-Br-cGMP.