|Description||CCG-1423 is a novel inhibitor of RhoA/C-mediated gene transcription that is capable of inhibiting invasion of PC-3 prostate cancer cells in a Matrigel model of metastasis.|
K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C.
ARS-853 is a selective, allele-specific inhibitor of KRAS, which blocks KRAS signaling and suppresses tumor growth (IC50= 2.5 μM).
FTI 277 trifluoroacetate salt
FTI 277 is a prodrug form of FTI 276 that inhibits farnesyltransferase (FTase) (IC50 = 0.5 nM) with antiproliferative activity. It potently inhibits H-Ras and K...
Pan-RAS-IN-1 is a pan-Ras inhibitor and exhibits lethality in cells partially dependent on expression of Ras proteins.
K-Ras(G12C) inhibitor 12
K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C).
CASIN is a selective GTPase Cdc42 inhibitor ( IC50=2 uM), reduces active levels of Cdc42 in aged hematopoietic stem cells.
K-Ras G12C-IN-2 is a novel and irreversible inhibitor of mutant K-ras G12C.
ML-098, also called as CID-7345532, is an activator of the GTP-binding protein Rab7 (EC50 = 77.6 nM) with selectivity without disrupting related GTPases cdc42, ...
6H05 is a selective inhibitor of oncogenic mutant K-Ras(G12C) without affecting wild-type K-Ras.
K-Ras G12C-IN-3 is a novel and irreversible inhibitor of mutant K-ras G12C.
Kobe0065 is a small-molecule Ras inhibitor that displays antitumor activity by blocking the Ras-effector interaction. Kobe0065 binds to Ras-GTP, blocking intera...
BQU57, a derivative of RBC8, is a selective GTPase Ral inhibitor relative to the GTPases Ras and RhoA.
Kobe2602, an analog of Kobe0065 , is a potent and selective RAS inhibitor, which exhibits inhibitory activity toward H-Ras GTP-c-Raf-1 binding both in vivo and ...
MCP110 is an Ras/Raf-1 interaction inhibitor. The Ras signaling pathway is activated either by direct mutation of Ras or its effector B-Raf. MCP110 was shown to...
MDK30165, also known as K-Ras(G12C) Inhibitor 6, is an irreversible, allosteric inhibitor of the K-Ras(G12C) mutant that causes 100% modification of the protein...
Oncrasin-1 is a potent and effective anticancer inhibitor that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations...
CCG-1423 is a novel inhibitor of RhoA/C-mediated gene transcription that is capable of inhibiting invasion of PC-3 prostate cancer cells in a Matrigel model of ...
Salirasib is a salicylic acid derivative with potential antineoplastic activity. Salirasib dislodges all Ras isoforms from their membrane-anchoring sites, there...
ML 210 is a selective RAS inhibitor that kills cells induced to express mutant RAS. ML210 exhibits nanomolar potency against two HRASG12V expressing cell lines ...