Sodium salicylate
(CAS: 54-21-7)

Sodium salicylate is used in medicine as an analgesic and antipyretic.

Recoflavone
(CAS: 203191-10-0)

Recoflavone, also referred to DA 6034, is a synthetic flavonoid derivative known to possess anti-inflammatory activity in phase Ⅲ clinical trials for the treatm...

Edasalonexent
(CAS: 1204317-86-1)

Edasalonexent, also known as CAT-1004, is a NF-kappa B inhibitor under the development of Catabasis Pharmaceuticals and Sarepta Therapeutics. It is a Inflammati...

Indole-3-carbinol
(CAS: 700-06-1)

Indole-3-carbinol is an inhibitor of cell growth via suppressing incorporation of [3H]thymidine, triggering G1 cell cycle arrest and downregulation of cyclin-de...

(R)-alpha-Lipoic Acid
(CAS: 1200-22-2)

(R)-alpha-Lipoic Acid, a vitamin-like organosulfur compound, is widely used as a dietary supplement and antioxidant. It has been also found to influence the act...

Oleandrin
(CAS: 465-16-7)

Oleandrin, also known as PBI-05204, is a lipid soluble cardiac glycoside with potential antineoplastic activity. Upon administration, oleandrin specifically bin...

CBL0137
(CAS: 1197996-80-7)

CBL0137 is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 µM and inhibits NF-κB with an EC50 of 0.47 µM. It also inhibits histone ...

SP 100030
(CAS: 154563-54-9)

SP 100030 is a potent dual inhibitor of NF-κB and AP-1 transcriptional activity (IC50 = 50 nM). SP 100030 blocks production of IL-2, IL-8 and TNF-α from Jurkat ...

Methysticin
(CAS: 20697-20-5)

Methysticin, the first Kava-pyrone isolated from the active constituents of rhizome extracts from Piper methysticum-a shrub indigenous to South Pacific islands,...

IT 901
(CAS: 1584121-99-2)

IT 901, a bioactive naphthalenethiobarbiturate derivative, potently inhibits the NF-κB subunit c-​Rel with IC50 value of 3 μM. It shows its anticancer propertie...

N-Acetylcysteine amide
(CAS: 38520-57-9)

N-Acetylcysteine amide is a blood brain barrier permeant and cell membranes thiol antioxidant with anti-inflamatory activity via regulation of activation of NF-...

Andrographolide
(CAS: 5508-58-7)

Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata.

(D)-(+)-Neopterin
(CAS: 2009-64-5)

Neopterin, a pyrazino-pyrimidine compound derived from GTP, n is a precursor of tetrahydrobiopterin and can be used as a biochemical marker indicative of cell p...

Adjudin
(CAS: 252025-52-8)

Adjudin, formerly called as AF-2364, an analog of lonidamine， attenuates microglia activation by suppression of the NF-κB pathway. Adjudin has potent anti-sperm...

Diroximel Fumarate
(CAS: 1577222-14-0)

Diroximel Fumarate is a prodrug of monomethyl fumarate in a controlled-release formulation that rapidly and efficiently converts to MMF in the body. It reduces ...

Diethylmaleate
(CAS: 141-05-9)

Diethylmaleate, a glutathione-depleting compound, is the diethyl ester of maleic acid and inhibits NF-kB. It is used as a reagent in the synthesis of several or...

QNZ
(CAS: 545380-34-5)

QNZ (EVP4593) shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM, respectively.

Harpagoside
(CAS: 19210-12-9)

Harpagoside, isolated from the Harpagophytum procumbens (Devil's Claw) root or Crophularia ningpoensis Hemsl (Figwort), inhibited lipopolysaccharide-induced mRN...

JSH-23
(CAS: 749886-87-1)

JSH-23 is a nuclear factor-kappa B (NF-κB) nuclear translocation inhibitor. JSH-23 inhibits LPS and cytokine-induced nuclear translocation of the p65 subunit of...

INCA-6
(CAS: 3519-82-2)

INCA-6, a cell-permeable quinone compound, is a selective and potent inhibitor of Calcineurin Nuclear Factor of Activated T cells (NFAT) signaling. It binds to ...