|Description||Catharanthine inhibits nicotinic receptor mediated diaphragm contractions with IC50 of 59.6 μM.|
A-366833 is a an agonist at neural nicotinic acetylcholine receptors selective for the α4β2 subtype.
SEN 12333 is a brain penetrating and orally bioactive α7 nicotinic acetylcholine receptor (nAChR) agonist (EC50 = 1.6 μM, Ki = 260 nM at rat α7 nAChRs) exhibiti...
α-Conotoxin EI is a selective antagonist of neuromuscular nicotinic receptors α1β1γδ. It shows selectivity for α/δ sites over α/γ sites in Torpedo.
Bradanicline acts as a partial agonist at the α7 subtype of the neural nicotinic acetylcholine receptors. It showed cognitive enhancing effects in animal studie...
Bradanicline hydrochloride is Alpha-7 Nicotinic Receptor Agonist. It showed cognitive enhancing effects in animal studies, and was being developed as a potentia...
Pentolonium tartrate is the tartrate salt form of pentolinium, which is a ganglionic blocking agent and acts as a nicotinic acetylcholine receptor antagonist. I...
DMAB-anabaseine dihydrochloride is a partial agonist at α7-containing neuronal nicotinic receptors and antagonist at α4β2 and other nicotinic receptors. It pote...
Sofinicline is a novel nicotinic acetylcholine receptor agonist under development of Abbott Laboratories. Till now, no development was reported for Phase-II for...
SSR 180711 hydrochloride
SSR 180711 hydrochloride is a partial agonist at α7 nAChR. It enhances episodic memory and reverses MK-801-induced deficits in retention of episodic memory. SSR...
Cisatracurium besylate is a neuromuscular blocking agent that is used in liver transplant patient with safety. Cisatracurium besylate is also an enantiomer of A...
ABT-594, also called as Tebanicline, the (R)-enantiomer of A-98593, is a potent synthetic non-opioid nicotinic analgesic drug. ABT-594 is a novel nAChR ligan wh...
Sazetidine A hydrochloride
Sazetidine A hydrochloride is an α4β2 nicotinic acetylcholine receptor ligand (Ki = 0.26 and 54 nM at α4β2 and α3β4 receptors, respectively), displaying analges...
(±)-Acetylcarnitine chloride is a weak cholinergic receptor agonist. It is used as an important intermediate in lipid metabolism.
Varenicline (trade name Chantix in the USA and Champix in Canada, Europe and other countries, marketed by Pfizer, usually in the form of varenicline tartrate), ...
NS 9283 is an allosteric modulator of α4β2 receptor affecting the potency of acetylcholine related events. It can reduce the rate of recovery from desensitizati...
MR 16728 hydrochloride
MR 16728 hydrochloride, an analog of cetiedil, enhanced acetylcholine (ACh) release (up to 145% of control) from Torpedo synaptosomes when the release was trigg...
α-Conotoxin AuIB is a selective antagonist of α3β4 nicotinic acetylcholine receptors. It shows > 100-fold selectivity over other receptor subunit combinations.
4BP-TQS is an allosteric agonist of α7 nicotinic acetylcholine receptors (nAChR). It binds to an allosteric transmembrane site, and exhibits a more potent and e...
TMPH hydrochloride is a potent and non-competitive antagonist of neuronal nicotinic ACh receptors (nAChRs). It produces long-lasting inhibition of neuronal nACh...