(-)-Catechin gallate - CAS 130405-40-2
Catalog number: 130405-40-2
Category: Inhibitor
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Molecular Formula:
Molecular Weight:
(-)-catechin gallate, an antioxidant component existing in green tea, has been found to be probably effective in restraining tyrosine phosphorylation caused by VEGF and have potential activity in the study of breast cancer.
White powder
(-)-CG;(-)-Catechin gallate;(2S,3R)-2-(3,4-Dihydroxyphenyl)-3-(3,4,5-trihydroxybenzoyloxy)-3,4-dihydro-2H-1-benzopyran-5,7-diol;3,4,5-Trihydroxybenzoic acid [[(2S)-2β-(3,4-dihydroxyphenyl)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran]-3α-yl] ester
10 mM in DMSO
-20ºC Freeze
(-)-catechin gallate has been found to be probably effective in restraining tyrosine phosphorylation caused by VEGF and have potential activity in the study of breast cancer.
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Canonical SMILES:
1.Neuroprotection by epigallo catechin gallate against bupivacaine anesthesia induced toxicity involves modulation of PI3/Akt/PTEN signalling in N2a and SH-SY5Y cells.
Wang LY1, Li X1, Han YZ1. Int J Clin Exp Med. 2015 Sep 15;8(9):15065-75. eCollection 2015.
Bupivacaine, an amide type long-acting local anaesthetic is commonly employed for epidural anesthesia and as well for nerve blockades. However, studies have shown neurotoxicity following local administration of bupivacaine raising concerns over the use of the drug. Compounds that could minimize or inhibit toxic effects of bupivacaine are of high value in operative settings and in pain management. The present study aims to investigate if epigallo catechin gallate (EGCG) could inhibit or prevent bupivacaine toxicity in neuroblastoma cells (N2a and SH-SY5Y). The viability of N2a and SH-SY5Y cells following exposure to EGCG (10-50 µM) were assessed by MTT assay and Annexin V/PI staining. The influence of EGCG on ROS generation was determined. The expression of apoptotic cascade proteins (Caspases-3, -8 and -9, Bcl-xL, Bad, Bax, Bcl-2) and PI3/Akt pathway proteins (Akt, p-Akt, GSK-3β, p-GSK-3β, PTEN) were analyzed by western blotting. EGCG improved the viability of the cells and inhibited apoptosis by potentially decreasing the expression of caspases and pro-apoptotic proteins.
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CAS 130405-40-2 (-)-Catechin gallate

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