Catalpol - CAS 2415-24-9
Catalog number: 2415-24-9
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Catalpol can be extracted from the herb of Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey. It primary function is to stimulate the production of adrenal cortical hormones, which increases the production of sex hormones. Catalpol also exhibits anti
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White powder
Soluble in DMSO
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -107℃ for long term (months to years).
Enzyme inhibitor/antihistaminic
Quality Standard:
Shelf Life:
2 years
Boiling Point:
675.6±55.0 °C | Condition: Press: 760 Torr
Melting Point:
207 °C
1.72±0.1 g/cm3
Canonical SMILES:
1.Simultaneous determination of loganin, morroniside, catalpol and acteoside in normal and chronic kidney disease rat plasma by UPLC-MS for investigating the pharmacokinetics of Rehmannia glutinosa and Cornus officinalis Sieb drug pair extract.
Zhao M1, Tao J1, Qian D1, Liu P1, Shang EX1, Jiang S2, Guo J1, Su SL1, Duan JA3, Du L1. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jan 15;1009-1010:122-9. doi: 10.1016/j.jchromb.2015.12.020. Epub 2015 Dec 14.
A sensitive and rapid method for determination of loganin, morroniside, catalpol and acteoside in rat plasma after oral administration of Rehmannia glutinosa Libosch and Cornus officinalis Sieb drug pair based on ultra-high performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS). Chromatographic separation was achieved using an Acquity UPLC BEH C18 column (100mm×2.1mm, 1.7μm) at a flow rate of 0.4mL/min, using gradient mode containing 0.1% formic acid in water and acetonitrile were used as the mobile phase A and B. Loganin, morroniside, catalpol, acteoside and the internal standard (chloramphenicol) were detected by selected reaction monitoring in the negative ion mode with the mass transition of m/z 451.0→179.0 (morroniside), m/z 435.0→227.0 (loganin), m/z 407.1→199.1 (catalpol), m/z 623.2→161.0 (acteoside) and m/z 320.8→151.9 (chloramphenicol), respectively. All calibration curves showed good linearity (r>0.
2.Biotransformation and metabolic profile of catalpol with human intestinal microflora by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.
Tao JH1, Zhao M2, Wang DG3, Yang C3, Du LY2, Qiu WQ3, Jiang S2. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jan 15;1009-1010:163-9. doi: 10.1016/j.jchromb.2015.12.007. Epub 2015 Dec 19.
Traditional Chinese medicine (TCM) has been used in clinical practice for thousands of years. Catalpol, an iridoid glucoside, abundantly found in the root of the common used herb medicine Rehmannia glutinosa Libosch, has been reported to show various biological effects and pharmacological activities. After oral administration, the active ingredient might have interactions with the intestinal bacteria, which could help unravel how the medicine was processed in vivo. In this work, different pure bacteria from healthy human feces were isolated and used to bioconvert catalpol. Ultra performance liquid chromatography/quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF/MS) technique combined with Metabolynx(™) software was applied to analyze catalpol metabolites. Compared with blank samples, parent compound (M0) and four metabolites (M1-M4) were detected and tentatively identified based on the characteristics of their protonated ions. The metabolites were likely to be: catalpol aglycone (M1), acetylated catalpol (M2), dimethylated and hydroxylated catalpol aglycone (M3), nitrogen-containing catalpol aglycone (M4).
3.Catalpol induces oligodendrocyte precursor cell-mediated remyelination in vitro.
Yuan CX1, Chu T2, Liu L3, Li HW3, Wang YJ3, Guo AC4, Fan YP1. Am J Transl Res. 2015 Nov 15;7(11):2474-81. eCollection 2015.
In demyelinating diseases such as multiple sclerosis, one of the treatment strategies includes remyelination using oligodendrocyte precursor cells (OPC). Catalpol, the extract of radix rehmanniae, is neuroprotective. Using an OPC culture model, we showed that 10 μM catalpol promotes OPC proliferation, cell migration and differentiation into mature oligodendrocytes. The 10 μM catalpol displayed stronger effects on OPCs migration and oligodendrocyte differentiation. These results suggest that catalpol has a potential role in promoting remyelination in demyelinating diseases, and is of therapeutic interest.
4.Anti-diabetic activities of catalpol in db/db mice.
Bao Q1, Shen X1, Qian L2, Gong C1, Nie M1, Dong Y1. Korean J Physiol Pharmacol. 2016 Mar;20(2):153-60. doi: 10.4196/kjpp.2016.20.2.153. Epub 2016 Feb 23.
The objective was to investigate the hypoglycemic action of catalpol in spontaneous diabetes db/db mice. 40 db/db mice were randomly divided into fi ve groups: model control gourp; db/db plus catalpol 40, 80, 120 mg/kg body wt. groups and db/db plus metformin 250 mg/kg group. Age-matched db/m mice were selected as normal control group. The mice were administered with corresponding drugs or solvent by gavage for 4 weeks. The oral glucose tolerance test was carried out at the end of 3(rd) week. After 4 weeks of treatment, the concentrations of fasting blood glucose (FBG), glycated serum protein (GSP), insulin (INS), triglyceride (TG), total cholesterol (TC) and adiponection (APN) in serum were detected. The protein expressions of phosphorylation-AMPKα1/2 in liver, phosphorylation-AMPKα1/2 and glucose transporter-4 (GLUT-4) in skeletal muscle and adipose tissues were detected by western blot. Real time RT-PCR was used to detect the mRNA expressions of acetyl-CoA carboxylase (ACC) and Hydroxymethyl glutaric acid acyl CoA reductase (HMGCR) in liver.
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CAS 2415-24-9 Catalpol

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