Carteolol Hydrochloride - CAS 51781-21-6
Catalog number:
51781-21-6
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C16H25ClN2O3
Molecular Weight:
328.83
COA:
Inquire
Targets:
Adrenergic Receptor
Description:
Carteolol HCl is a β-adrenoceptor antagonist, used for the treatment of glaucoma.
Publictions citing BOC Sciences Products
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Purity:
>98%
MSDS:
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1.Comparative enantiomer affinity pattern of β-blockers in aqueous and nonaqueous CE using single-component anionic cyclodextrins.
Feng Y1, Wang T1, Jiang Z1, Chankvetadze B2, Crommen J1,3. Electrophoresis. 2015 Jun;36(11-12):1358-64. doi: 10.1002/elps.201400462. Epub 2015 Jan 29.
A series of eight chiral β-blocker drugs, acebutolol, atenolol, carazolol, carteolol, carvedilol, propranolol, sotalol, and talinolol, have been enantioseparated using two single-component anionic β-CD derivatives, namely heptakis (2,3-di-O-methyl-6-sulfo)-β-CD (HDMS-β-CD) and heptakis (2,3-di-O-acetyl-6-sulfo)-β-CD (HDAS-β-CD), in aqueous CE and NACE. The influence of the nature of substituents (methyl or acetyl) in positions 2 and 3 on the CD derivatives and of the electrophoretic medium (water or methanol) on the enantioselectivity and enantiomer affinity pattern (EAP) of these structurally related compounds was systematically studied. All eight β-blockers could be enantioseparated at least partially in the four CE systems, except sotalol with HDMS-β-CD in NACE. In general, lower affinity and enantioselectivity were obtained in the presence of HDMS-β-CD compared to HDAS-β-CD. Reversals of EAPs were observed for all compounds. EAPs toward these two CDs were found to be opposite to each other in NACE for all compounds except carvedilol and in aqueous CE for atenolol, carteolol, talinolol, and sotalol.
2.Effects of topical carteolol on retinal arterial blood flow in primary open-angle glaucoma patients.
Kawai M1, Nagaoka T, Takahashi A, Sato E, Yoshida A. Jpn J Ophthalmol. 2012 Sep;56(5):458-63. doi: 10.1007/s10384-012-0156-1. Epub 2012 Jun 14.
PURPOSE: Our aim was to evaluate the effects of topical carteolol on retinal arterial blood flow (RBF) in patients with primary open-angle glaucoma.
3.Comparative Effectiveness of First-Line Medications for Primary Open-Angle Glaucoma: A Systematic Review and Network Meta-analysis.
Li T1, Lindsley K2, Rouse B3, Hong H4, Shi Q3, Friedman DS5, Wormald R6, Dickersin K2. Ophthalmology. 2016 Jan;123(1):129-40. doi: 10.1016/j.ophtha.2015.09.005. Epub 2015 Oct 31.
TOPIC: Primary open-angle glaucoma (POAG) is a highly prevalent condition worldwide and the most common cause of irreversible sight loss. The objective is to assess the comparative effectiveness of first-line medical treatments in patients with POAG or ocular hypertension through a systematic review and network meta-analysis, and to provide relative rankings of these treatments.
4.Chitosan nanoparticles amplify the ocular hypotensive effect of cateolol in rabbits.
Ameeduzzafar1, Ali J1, Bhatnagar A2, Kumar N2, Ali A3. Int J Biol Macromol. 2014 Apr;65:479-91. doi: 10.1016/j.ijbiomac.2014.02.002. Epub 2014 Feb 11.
PURPOSE: To assess the potential of chitosan (CS) nanoparticles for ocular drug delivery by investigating their intraocular retention by γ-scintigraphy and intraocular pressure reduction.
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