Carprofen - CAS 53716-49-7
Catalog number:
53716-49-7
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C15H12ClNO2
Molecular Weight:
273.71
COA:
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Targets:
Cox-2 | COX
Description:
A COX-2 inhibitor; A non-steroidal anti-inflammatory drug
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Brife Description:
A COX-2 inhibitor; A non-steroidal anti-inflammatory drug
Appearance:
Off-White Solid
Synonyms:
6-Chloro-α-methyl-9H-carbazole-2-acetic Acid; (dl)-6-Chloro-α-methylcarbazole- 2-acetic Acid; C 5720; Carprodyl; (+/-)-Carprofen; Imadyl; NSC 297935; Rimadyl; Ro 20-5720;
Solubility:
10 mM in DMSO
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
MSDS:
Inquire
Quantity:
Grams-Kilos
Melting Point:
>183°C (dec.)
InChIKey:
PUXBGTOOZJQSKH-UHFFFAOYSA-N
InChI:
1S/C15H12ClNO2/c1-8(15(18)19)9-2-4-11-12-7-10(16)3-5-13(12)17-14(11)6-9/h2-8,17H,1H3,(H,18,19)
Canonical SMILES:
CC(C1=CC2=C(C=C1)C3=C(N2)C=CC(=C3)Cl)C(=O)O
1.Effects of concurrent perioperative use of marbofloxacin and cimicoxib or carprofen in dogs.
Weil C1, Tünsmeyer J1, Tipold A2, Hoppe S3, Beyerbach M4, Pankow WR5, Kästner SB1. J Small Anim Pract. 2016 Mar 31. doi: 10.1111/jsap.12464. [Epub ahead of print]
OBJECTIVES: To investigate possible interactions visible on electroencephalogram recordings caused by concomitant administration of marbofloxacin and carprofen or cimicoxib in dogs without central nervous system disease.
2.Antibody production in rabbits administered Freund's complete adjuvant and carprofen concurrently.
Fishback JE, Stronsky SM, Green CA, Bean KD, Froude JW. Lab Anim (NY). 2016 Jan 27;45(2):63-6. doi: 10.1038/laban.937.
Freund's complete adjuvant (FCA) is a commonly used immunopotentiator that can boost polyclonal antibody production in animal models such as rabbits, but FCA is also known to cause inflammation and pain. It is important to balance the welfare of animals with the goal of efficiently producing antibodies, but little is known about how common treatments for pain and inflammation, such as non-steroidal anti-inflammatory drugs (NSAIDs), affect the production of polyclonal antibodies. The purpose of this study was to measure polyclonal antibody production in rabbits that were administered FCA either with or without a concurrent treatment of a NSAID, carprofen. Rabbits were divided into two groups and were administered identical treatments of an antigen with adjuvant, and the treatment group also received carprofen injections at different stages of the study. Carprofen treatment did not significantly affect polyclonal antibody production, which suggests that carprofen and other NSAIDs can be used alongside FCA in rabbits to achieve desired levels of antibody production while minimizing pain and distress associated with the use of FCA.
3.Antibody production in rabbits administered Freund's complete adjuvant and carprofen concurrently.
Fishback JE, Stronsky SM, Green CA, Bean KD, Froude JW. Lab Anim (NY). 2016 Jan 27;45(2):63-6. doi: 10.1038/laban.937.
Freund's complete adjuvant (FCA) is a commonly used immunopotentiator that can boost polyclonal antibody production in animal models such as rabbits, but FCA is also known to cause inflammation and pain. It is important to balance the welfare of animals with the goal of efficiently producing antibodies, but little is known about how common treatments for pain and inflammation, such as non-steroidal anti-inflammatory drugs (NSAIDs), affect the production of polyclonal antibodies. The purpose of this study was to measure polyclonal antibody production in rabbits that were administered FCA either with or without a concurrent treatment of a NSAID, carprofen. Rabbits were divided into two groups and were administered identical treatments of an antigen with adjuvant, and the treatment group also received carprofen injections at different stages of the study. Carprofen treatment did not significantly affect polyclonal antibody production, which suggests that carprofen and other NSAIDs can be used alongside FCA in rabbits to achieve desired levels of antibody production while minimizing pain and distress associated with the use of FCA.
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CAS 53716-49-7 Carprofen

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