Cardiogenol c hydrochloride - CAS 1049741-55-0
Catalog number: 1049741-55-0
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C12H15ClN4O2
Molecular Weight:
282.73
COA:
Inquire
Targets:
Others
Description:
The hydrochloride salt form of Cardiogenol C, a pyrimidine derivative, might be able to induce embryonic stem cells (ESCs) into cardiomyocytes. It is significant in the cell-based therapy of heart disease. EC50: 100 nM.
Publictions citing BOC Sciences Products
  • >> More
Purity:
98%
Related CAS:
1049741-55-0 (HCl); 671225-39-1 (Free base)
Appearance:
Solid powder
Synonyms:
2-((2-((4-methoxyphenyl)amino)pyrimidin-4-yl)amino)ethan-1-ol hydrochloride; Cardiogenol C; Cardiogenol C HCl; Cardiogenol C hydrochloride
Solubility:
DMSO: > 59 mg/mL
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
The hydrochloride salt form of Cardiogenol C could be probably able to induce embryonic stem cells (ESCs) into cardiomyocytes.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
InChIKey:
QQAHYSZVJLHCNA-UHFFFAOYSA-N
InChI:
1S/C13H16N4O2.ClH/c1-19-11-4-2-10(3-5-11)16-13-15-7-6-12(17-13)14-8-9-18;/h2-7,18H,8-9H2,1H3,(H2,14,15,16,17);1H
Canonical SMILES:
COC1=CC=C(NC2=NC(NCCO)=CC=N2)C=C1.Cl
1.Cardiogenic shock associated with reversible dilated cardiomyopathy during therapy with regular doses of venlafaxine.
Charniot JC1, Vignat N, Monsuez JJ, Kidouche R, Avramova B, Artigou JY, Albertini JP. Am J Emerg Med. 2010 Feb;28(2):256.e1-5. doi: 10.1016/j.ajem.2009.05.010.
We report a cardiac complication in a patient treated with regular doses of venlafaxine. A 49-year-old man with prior normal cardiac function and stable chronic hepatitis C was treated for a major depressive disorder with usual doses of venlafaxine during an 8-month period until the occurrence of a cardiogenic shock in a context of dilated cardiomyopathy. Three months after withdrawal of the drug, the left ventricular ejection fraction returned to normal values. Cardiomyopathy is a rare complication with high doses of venlafaxine that was not previously reported in patients free of prior cardiac disease and cardiomyopathy and treated with usual doses (initially 150 mg daily; after 3 months, 75 mg daily). An objective assessment revealed that venlafaxine was probably implied in the subsequent development of cardiomyopathy when considering the Naranjo Probability Scale. Physicians who usually prescribe venlafaxine have to be briefed on such potential cardiac adverse effects even with usual doses.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 484-29-7 Dictamine

Dictamine
(CAS: 484-29-7)

Dictamnine has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma cells; It has been reported to have antimicrobial activity against b...

CP-5484
(CAS: 352308-27-1)

CP-5484 is a synthetic bio-active chemical with potent anti-MRSA activity and low acute toxicity.

CAS 67879-58-7 Caftaric acid

Caftaric acid
(CAS: 67879-58-7)

Caftaric acid is a natural productwhich was reported as an inhibitor of the protein-protein interactions mediated by the Src-family kinases.

CAS 151358-47-3 DIM-C-pPhOH

DIM-C-pPhOH
(CAS: 151358-47-3)

DIM-C-pPhOH is a Nur77 (NR4A1) antagonist. It inhibits TGF-β induced cell migration in breast cancer cell lines, and promotes ROS/endoplasmic reticulum stress a...

CAS 51014-29-0 Isocorynoxeine

Isocorynoxeine
(CAS: 51014-29-0)

Isocorynoxeine is a alkaloid extracted from Uncaria Hook shows the effects of lowering blood pressure.

CAS 124190-19-8 FR 901235

FR 901235
(CAS: 124190-19-8)

This active molecular is an immunoactive substance that produced by Paecilomyces carneus F-4882, an imperfect fungus. FR-901235 can lead to the mitogen-induced ...

CAS 518-69-4 Corydaline

Corydaline
(CAS: 518-69-4)

Corydaline, extracted from Corydalis ambigua, is one of the major active constituents in a new prokinetic botanical agent exhibiting the antiacetylcholinesteras...

S Tag Peptide

S Tag Peptide, a 15 amino acid peptide derived from RNase A, is an oligopeptide used for improving protein solubility.

CAS 222716-34-9 SZL P1-41

SZL P1-41
(CAS: 222716-34-9)

SZL P1-41 is a Skp2 inhibitor that prevents assembly of Skp2-Skp1 complexes. SZL P1-41 selectively suppresses Skp2 SCF E3 ligase activity but not the activity o...

FR-182024
(CAS: 179034-83-4)

FR-182024, an azabicyclo derivative, has been found to have potential activity as an anti-Helicobacter pylori agent and was once stuied against helicobacter inf...

CAS 1146-99-2 Chlophenadione

Chlophenadione
(CAS: 1146-99-2)

Chlophenadione, an analogue of bromindione, could be used as an orally bioavaliable anticoagulant.

CAS 3624-96-2 Bialamicol hydrochloride

Bialamicol hydrochloride
(CAS: 3624-96-2)

Bialomicol is a synthetic bio-active chemical.

CAS 68506-86-5 Vigabatrin

Vigabatrin
(CAS: 68506-86-5)

Vigabatrin is a structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transa...

CAS 71610-00-9 Cephalomannine

Cephalomannine
(CAS: 71610-00-9)

Cephalomannine is an active anti-cancer agent obtained from Taxus yunnanensis and has an antineoplastic effect on tumors found in mice.

CAS 148-79-8 Thiabendazole

Thiabendazole
(CAS: 148-79-8)

Thiabendazole inhibites the mitochondrial helminth-specific enzyme, fumarate reductase, with anthelminthic property.

CAS 130693-82-2 Dorzolamide hydrochloride

Dorzolamide hydrochloride
(CAS: 130693-82-2)

Dorzolamide hydrochloride is a carbonic anhydrase inhibitor. It is an anti-glaucoma agent and topically applied in the form of eye drops. Dorzolamide hydrochlor...

CAS 121776-33-8 Furilazole

Furilazole
(CAS: 121776-33-8)

Furilazole, an oxazole derivative, is a herbicide commonly used for gramineous crops.

P21d hydrochloride

P21d hydrochloride is a breast tumor kinase inhibitor with IC50 value of 30 nM. It can restore E-cadherin expression and suppress migration in breast cancer cel...

CAS 153381-68-1 7-Epi-docetaxel

7-Epi-docetaxel
(CAS: 153381-68-1)

An isomer of Docetaxel (D494420). Docetaxel injection impurity C.

CAS 35449-36-6 Gemcadiol

Gemcadiol
(CAS: 35449-36-6)

Gemcadiol is a new antilipemic drug with lipid-regulating properties.

Chemical Structure

CAS 1049741-55-0 Cardiogenol c hydrochloride

Quick Inquiry

Verification code

Featured Items