Carboxypeptidase G2 (CPG2) Inhibitor - CAS 192203-60-4
Catalog number:
192203-60-4
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C13H15NO6S
Molecular Weight:
313.33
COA:
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Targets:
Carboxypeptidase
Description:
A novel Carboxypeptidase G2 (CPG2) Inhibitor, Antitumor agents.
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Purity:
>98%
Synonyms:
CPG2 Inhibitor; L-Glutamic acid, N-[[(4-methoxyphenyl)thio]carbonyl]-
MSDS:
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1.Novel inhibitors of carboxypeptidase G2 (CPG2): potential use in antibody-directed enzyme prodrug therapy.
Khan TH1, Eno-Amooquaye EA, Searle F, Browne PJ, Osborn HM, Burke PJ. J Med Chem. 1999 Mar 25;42(6):951-6.
The design and synthesis of potent thiocarbamate inhibitors for carboxypeptidase G2 are described. The best thiocarbamate inhibitor N-(p-methoxybenzenethiocarbonyl)amino-L-glutamic acid 6d, chosen for preliminary investigations of in vitro antibody-directed enzyme prodrug therapy (ADEPT), abrogated the cytotoxicity of a combination of A5B7-carboxypeptidase G2 conjugate and prodrug PGP (N-p-{N,N-bis (2-chloroethyl)amino}phenoxycarbonyl-L-glutamate) toward LS174T cells. This is the first report of a small-molecule enzyme inhibitor proposed for use in conjunction with the ADEPT approach.
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