Carbinoxamine - CAS 486-16-8
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Carbinoxamine is a antihistamine and anticholinergic agent used in the treatment of severe itching in patients with CD5.
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White to Off-White Solid
Soluble in DMSO
Store at -20 °C
Analgesic and anti-inflammatory compound.
Quality Standard:
Enterprise standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly.
Canonical SMILES:
1.Pro-arrhythmic potential of oral antihistamines (H1): combining adverse event reports with drug utilization data across Europe.
Poluzzi E1, Raschi E1, Godman B2, Koci A1, Moretti U3, Kalaba M4, Wettermark B5, Sturkenboom M6, De Ponti F1. PLoS One. 2015 Mar 18;10(3):e0119551. doi: 10.1371/journal.pone.0119551. eCollection 2015.
BACKGROUND: There is appreciable utilisation of antihistamines (H1) in European countries, either prescribed by physician and purchased by patients for self-medication. Terfenadine and astemizole underwent regulatory restrictions in '90 because of their cardiac toxicity, but only scarce clinical data are available on other antihistamines.
2.Enantioseparation of Six Antihistamines with Immobilized Cellulose Chiral Stationary Phase by HPLC.
Zhou J1, Luo P2, Chen S2, Meng L2, Sun C2, Du Q2, Sun F2. J Chromatogr Sci. 2016 Apr;54(4):531-5. doi: 10.1093/chromsci/bmv177. Epub 2015 Dec 10.
A stereoselective high performance liquid chromatography method has been developed for the chiral separation of the enantiomers of six antihistamines, doxylamine, carbinoxamine, dioxopromethazine, oxomemazine, cetirizine and hydroxyzine. The effects of mobile phase additive, column temperature and flow rate on the retention time and resolution were studied. Enantiomeric separation of cetirizine, doxylamine and hydroxyzine were achieved on cellulose tris-(3,5-dichlorophenylcarbamate) immobilized on silica gel chiral stationary phase known as Chiralpak IC (RS = 3.74, RS = 1.85 and RS = 1.74, respectively).
3.[The efficacy of rinopront for the treatment of acute and chronic rhinitis in the children].
Chistiakova VR, Miasnikov LL. Vestn Otorinolaringol. 2012;(3):88-91.
The objective of the present study was to estimate the therapeutic efficacy of rinopront used to treat inflammatory diseases of the nasopharynx in the children. The study included 32 patients at the age between 12 and 14 years presenting with various forms of acute and chronic rhinitis. The children with infectious inflammatory rhinitis with concomitant catarrhal maxillary sinusitis and pronounced symptoms of rhino-conjunctival syndrome recovered within 4-5 days after the initiation of rhinopront therapy. The patients presenting with vasomotor and all-the-year-round allergic rhinitis needed two courses of treatment (5 days each) to recover. The duration of treatment of mild seasonal rhinitis was 4 days whereas the moderately severe disease required the second 5-day course of therapy to be performed to arrest the disease activity.
4.LC for analysis of two sustained-release mixtures containing cough cold suppressant drugs.
El-Gindy A1, Sallam S, Abdel-Salam RA. J Chromatogr Sci. 2010 Jul;48(6):507-12.
A liquid chromatographic method was applied for the analysis of two sustained-release mixtures containing dextromethorphane hydrobromide, carbinoxamine maleate with either phenylephrine hydrochloride in pharmaceutical capsules (Mix 1) or phenyl-propanolamine, methylparaben, and propylparaben, which bonds as a drug base to ion exchange resin in pharmaceutical syrup (Mix 2). The method was used for their simultaneous determination using a CN column with a mobile phase consisting of acetonitrile-12 mM ammonium acetate in the ratio of 60:40 (v/v, pH 6.0) for Mix 1 and 45:55 (v/v, pH 6.0) for Mix 2.
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CAS 486-16-8 Carbinoxamine

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