Captopril - CAS 62571-86-2
Catalog number:
62571-86-2
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C9H15NO3S
Molecular Weight:
217.29
COA:
Inquire
Targets:
Angiotensin-converting Enzyme (ACE)
Description:
Captopril is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of congestive heart failure.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
ISF 2522
MSDS:
Inquire
1.A network-based drug repositioning infrastructure for precision cancer medicine through targeting significantly mutated genes in the human cancer genomes.
Cheng F1, Zhao J1, Fooksa M2, Zhao Z3. J Am Med Inform Assoc. 2016 Mar 28. pii: ocw007. doi: 10.1093/jamia/ocw007. [Epub ahead of print]
OBJECTIVE: Development of computational approaches and tools to effectively integrate multidomain data is urgently needed for the development of newly targeted cancer therapeutics.
2.One-pot synthesis, biological evaluation, and docking study of new chromeno-annulated thiopyrano[2,3-c]pyrazoles.
Parmar BD1, Sutariya TR1, Brahmbhatt GC1, Parmar NJ2, Kant R3, Gupta VK3, Murumkar PR4, Sharma MK4, Yadav MR4. Mol Divers. 2016 Mar 26. [Epub ahead of print]
A one-pot synthesis of new chromeno-annulated thiopyrano[2,3-c]pyrazoles has been achieved through a domino-Knoevenagel-hetero-Diels-Alder reaction after combining various pyrazol-5-thiones with O-alkenyloxy/alkynyloxy-salicylaldehydes/naphthaldehydes in a Brønsted acidic ionic liquid, [Hmim]HSO[Formula: see text], methylimidazolium hydrogen sulphate, under microwave irradiation. The method is simple and in many cases the isolated products did not require further purification. The central pyranothiopyranyl cis-fusion was confirmed by 2D NMR NOESY and single-crystal X-ray analysis suggesting that the endo-E-Syn transition state would be the most favored pathway of the reaction. Many heterocycles of this new series were found active against six bacterial and two fungal strains. In addition, all the compounds possess good anti-oxidant activity with the ferric reducing anti-oxidant power value [Formula: see text]. All new structures were docked into active site of angiotensin I converting enzyme (ACE), assuming that the compounds possessed the anti-hypertensive activity potential on the basis of prediction of activity spectra of substances prediction results.
3.The Cooperative Effect of Local Angiotensin-II in Liver with Adriamycin Hepatotoxicity on Mitochondria.
Taskin E1, Guven C2, Sahin L3, Dursun N4. Med Sci Monit. 2016 Mar 28;22:1013-21.
BACKGROUND Adriamycin (ADR) is a drug used clinically for anticancer treatment; however, it causes adverse effects in the liver. The mechanism by which these adverse effects occur remains unclear, impeding efforts to enhance the therapeutic effects of ADR. Its hepatotoxicity might be related to increasing reactive oxygen species (ROS) and mitochondrial dysfunction. The interaction between ADR and the local renin-angiotensin system (RAS) in the liver is unclear. ADR might activate the RAS. Angiotensin-II (Ang-II) leads to ROS production and mitochondrial dysfunction. In the present study we investigated whether ADR's hepatotoxicity interacts with local RAS in causing oxidative stress resulting from mitochondrial dysfunction in the rat liver. MATERIAL AND METHODS Rats were divided into 5 groups: control, ADR, co-treated ADR with captopril, co-treated ADR with Aliskiren, and co-treated ADR with both captopril and Aliskiren. Mitochondria and cytosol were separated from the liver, then biochemical measurements were made from them.
4.SYNTHESIS AND IN VITRO CHARACTERIZATION OF HYDROXYPROPYL METHYLCELLULOSE-GRAFT-POLY (ACRYLIC ACID/2-ACRYLAMIDO-2-METHYL-1-PROPANESULFONIC ACID) POLYMERIC NETWORK FOR CONTROLLED RELEASE OF CAPTOPRIL.
Furqan Muhammad I, Mahmood A, Aysha R. Acta Pol Pharm. 2016 Jan-Feb;73(1):183-96.
A super-absorbent hydrogel was developed by crosslinking of 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS) and acrylic acid with hydroxypropyl methylcellulose (HPMC) for controlled release drug delivery of captopril, a well known antihypertensive drug. Acrylic acid and AMPS were polymerized and crosslinked with HPMC by free radical polymerization, a widely used chemical crosslinking method. N,N'-methylenebisacrylamide (MBA) and potassium persulfate (KPS) were added as cross-linker and initiator, respectively. The hydrogel formulation was loaded with captopril (as model drug). The concentration of captopril was monitored at 205 nm using UV spectrophotometer. Equilibrium swelling ratio was determined at pH 2, 4.5 and 7.4 to evaluate the pH responsiveness of the formed hydrogel. The super-absorbent hydrogels were evaluated by FTIR, SEM, XRD, and thermal analysis (DSC and TGA). The formation of new copolymeric network was determined by FTIR, XRD, TGA and DSC analysis.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Angiotensin-converting Enzyme (ACE) Products


CAS 88768-40-5 Cilazapril

Cilazapril
(CAS: 88768-40-5)

Cilazapril is a very potent and highly effective angiotensin-converting enzyme inhibitor (ACE inhibitor). It is used for the treatment of hypertension and conge...

CAS 88889-14-9 Fosinopril Sodium

Fosinopril Sodium
(CAS: 88889-14-9)

Fosinopril Sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor.

CAS 76095-16-4 Enalapril Maleate

Enalapril Maleate
(CAS: 76095-16-4)

Enalapril Maleate is an ACE inhibitor used in the treatment of hypertension, diabetic nephropathy, and some types of chronic heart failure.

CAS 83915-83-7 Lisinopril

Lisinopril
(CAS: 83915-83-7)

Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor with a number of properties distinguish it from other ACE inhibitors: It is hydrophilic, has a lo...

CAS 81938-43-4 Zofenopril calcium

Zofenopril calcium
(CAS: 81938-43-4)

Zofenopril Calcium is an antioxidant and acts as an angiotensin-converting enzyme (ACE) inhibitor. lt is also an inhibitor of PEPT2, the predominant peptide tra...

CAS 92077-78-6 Cilazapril Monohydrate

Cilazapril Monohydrate
(CAS: 92077-78-6)

Cilazapril is a angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and congestive heart failure.

CAS 75847-73-3 Enalapril

Enalapril
(CAS: 75847-73-3)

Enalapril is an angiotensin converting enzyme (ACE) inhibitor used in the treatment of hypertension, congestive heart failure, myocardial infarction, and diabet...

CAS 110221-44-8 Temocapril HCl

Temocapril HCl
(CAS: 110221-44-8)

Temocapril HCl is the hydrochloride of Temocapril, which is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.

CAS 82586-55-8 Quinapril HCl

Quinapril HCl
(CAS: 82586-55-8)

Quinapril HCl is the hydrochloride salt of quinapril that is an angiotensin-converting enzyme inhibitor with a Ki of 20 μM.

CAS 127103-11-1 N-Acetyl-Ser-Asp-Lys-Pro

N-Acetyl-Ser-Asp-Lys-Pro
(CAS: 127103-11-1)

N-Acetyl-Ser-Asp-Lys-Pro, formed in bone marrow cells by enzymatic processing of thymosin β4, is a natural and specific substrate for the N-terminal site of ACE...

CAS 76547-98-3 Lisinopril

Lisinopril
(CAS: 76547-98-3)

Lisinopril is a drug of the angiotensin-converting enzyme (ACE) inhibitor which is responsible for the conversion of angiotensin I (ATI) to angiotensin II. It i...

CAS 107133-36-8 Perindopril Erbumine

Perindopril Erbumine
(CAS: 107133-36-8)

Perindopril Erbumine displays a higher binding affinity for the bradykinin binding sites than the angiotensin I binding sites of the angiotensin-converting enzy...

CAS 83647-97-6 Spirapril

Spirapril
(CAS: 83647-97-6)

Spirapril is an ACE inhibitor. It can be used for the treatment of hypertension. Spirapril belongs to dicarboxy group of ACE inhibitors.

CAS 103733-49-9 Quinapril Diketopiperazine

Quinapril Diketopiperazine
(CAS: 103733-49-9)

Quinapril Diketopiperazine is a derivative and a metabolite of Quinapril that acts as an angiotensin-converting enzyme(ACE) inhibitor. It prevents the conversio...

CAS 167305-00-2 Omapatrilat

Omapatrilat
(CAS: 167305-00-2)

Omapatrilat, an octahydropyridothiazepine derivative, has been found to be an ACE inhibitor as well as an endopeptidase inhibitor and was once studied in heart ...

CAS 103775-10-6 Moexipril

Moexipril
(CAS: 103775-10-6)

Moexipril is a potent orally active nonsulfhydryl angiotensin converting enzyme(ACE) inhibitor with antihypertensive activity. It is used for the treatment of h...

CAS 152685-85-3 Hemorphin-7

Hemorphin-7
(CAS: 152685-85-3)

Hemorphin-7, a hemorphin peptide with antinociceptive and antihypertensive effects, is an endogenous opioid peptide derived from the β-chain of hemoglobin. Hemo...

CAS 84680-54-6 Enalaprilat Dihydrate

Enalaprilat Dihydrate
(CAS: 84680-54-6)

Enalaprilat is the active metabolite of enalapril. It is the first dicarboxylate-containing ACE inhibitor.

CAS 89396-94-1 Imidapril HCl

Imidapril HCl
(CAS: 89396-94-1)

Imidapril HCl is an ACE inhibitor used as an antihypertensive drug and for the treatment of chronic heart failure.

CAS 131-01-1 Deserpidine

Deserpidine
(CAS: 131-01-1)

Deserpidine is an antihypertensive drug related to Reserpine. It is naturally found in Rauvolfia spp. Deserpidine is a competitive ACE (angiotensin converting e...

Chemical Structure

CAS 62571-86-2 Captopril

Quick Inquiry

Verification code

Featured Items