|Description||Capsazepine, a benzazepine derivative, has been found to be a sensory neurone excitotoxin that could be used against hyperalgesic responses. IC50: 562 nM (Rat TRPV1).|
|Appearance||White to Light Yellow Solid|
|Solubility||DMSO: ≥ 50 mg/mL|
|Application||Capsazepine has been found to be a sensory neurone excitotoxin that could be used against hyperalgesic responses.|
|Shelf Life||As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly|
RN 1747, a selective TRPV4 agonist (EC50= 0.77, 4.0 and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively), represents the first drug-like TRPV4 antagonist with...
PF-4840154 has been foundd to be superior than Mustard Oil as a TrpA1 agonists. IC50: 97 nM and 23 nM (EC50) for hTrpA1 and rTrpA1 respectively.
SAR7334, a TRPC6 inhibitor, could be valuable in studying sorts of diseases related to TRPC.
AMG-517 is a potent and selective TRPV1 antagonist, antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM.
JNJ-17203212 is a novel, reversible, and selective TRPV1 antagonist which could not inhibit related TRP channels. Its IC50 values are 65 nM and 102 nM for human...
Pyr6, a pyrazole derivative, is a selective inhibitor of ransient receptor potential cation 3 (TRPC3) channels that inhibited Orai1- and TRPC3-mediated Ca(2+) e...
MK-2295 is a potent TRPV1 antagonist. TRPV1 antagonists has the potential as analgesic and anti-inflammatory agents.
TC-I 2014 is a potent TRPM8 antagonist (IC50 = 0.8, 3.0 and 4.4 nM for canine, human and rat channels, respectively) displaying antiallodynic properties in vivo...
Pyr3, a pyrazole derivative, is a selective antagonist of the TRP canonical 3 channel (TRPC3) which can function as a receptor-operated channel. It inhibits TRP...
Eact is a TMEM16A (ANO1) calcium-activated chloride channel (CaCC) activator (EC50 = 3 μM). Eact also stimulates transient receptor potential vanilloid 1 (TRPV1...
CIM 0216 has been found to be a selective TRPM3 agonist and could stimulate the release of insulin from pancreatic islet cells.
Pyr10, a pyrazole derivative, is a TRPC3-selective inhibitor that could be effective in the study of cellular functions. IC50: 0.72 uM and 13.08 uM for TRPC3-RO...
MK6-83 is a transient receptor potential channel ML3 activator with EC50 value of 110 nM. It can restore endolysosomal trafficking and zinc homeostasis in lysos...
ML SA1 is an activator of TRPML channels. It can induce TRPML-mediated Ca2+ release from lysosomes and reduce cholesterol accumulation in Niemann-Pick type C ma...
SB 452533 is a potent and selective TRPV1 antagonist against capsaicin (pKb = 7.7), noxious heat and acid-mediated (pIC50 = 7.0) receptor activation (pKi = 6.22...
Mavatrep is an orally bioavailable, potent and selective TRPV1 antagonist with Ki value of 6.5 nM, which exhibits minimal effect on the enzymatic activity of CY...
AM 0902 is an effective and selective TRPA1 antagonist and has been found to exhibit activities in biological pathways associated with pain.
Optovin is a reversible photoactive TRPA1 activator; stimulates human TRPA1 channels in vitro and enables repeated photoactivation of motor behaviors in wild-ty...
M8 B hydrochloride
M8 B hydrochloride is a selective and potent channel blocker of transient receptor potential melastatin 8 (TRPM8). It blocks cold-induced and icilin or methol-i...
OLDA is a vanilloid TRPV1 (VR1) receptor agonist with EC50 value of 36 nM at hVR1. OLDA is also a 5-lipoxygenase inhibitor with IC50 value of 7.5 nM.