Canfosfamide Hydrochloride - CAS 439943-59-6
Catalog number:
439943-59-6
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C26H41Cl5N5O10PS
Molecular Weight:
823.93
COA:
Inquire
Targets:
Others
Description:
Canfosfamide is a modified glutathione analogue as a small-molecule antineoplastic compound with potential antineoplastic activity. Canfosfamide is selectively activated by glutathione S-transferase P1-1 into an alkylating metabolite that forms covalent linkages with nucleophilic centers in tumor cell DNA, which may induce a cellular stress response and cytotoxicity, and decrease tumor proliferation. S-transferase P1-1 is an enzyme that is overexpressed in many human malignancies.
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Purity:
≥98%
Appearance:
Solid powder
Synonyms:
Telcyta; TER 286; TLK 286; N5-(((2-((bis(bis(2-chloroethyl)amino)phosphoryl)oxy)ethyl)sulfonyl)-D-alanyl)-N5-((R)-carboxy(phenyl)methyl)-L-glutamine hydrochloride;
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
Glutathione transferase inhibitor
Quality Standard:
Enterprise standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly.
Quantity:
Milligrams-Grams
InChIKey:
NECZZOFFLFZNHL-XVGZVFJZSA-N
InChI:
1S/C26H40Cl4N5O10PS.ClH/c27-8-12-34(13-9-28)46(42,35(14-10-29)15-11-30)45-16-17-47(43,44)18-21(32-22(36)7-6-20(31)25(38)39)24(37)33-23(26(40)41)19-4-2-1-3-5-19;/h1-5,20-21,23H,6-18,31H2,(H,32,36)(H,33,37)(H,38,39)(H,40,41);1H/t20-,21-,23+;/m0./s1
Canonical SMILES:
C(CN(P(=O)(N(CCCl)CCCl)OCCS(=O)(=O)C[C@H](NC(=O)CC[C@@H](C(=O)O)N)C(=O)N[C@H](c1ccccc1)C(=O)O)CCCl)Cl.Cl
Current Developer:
Telik
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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