|Description||Canfosfamide is a modified glutathione analogue as a small-molecule antineoplastic compound with potential antineoplastic activity. Canfosfamide is selectively activated by glutathione S-transferase P1-1 into an alkylating metabolite that forms covalent linkages with nucleophilic centers in tumor cell DNA, which may induce a cellular stress response and cytotoxicity, and decrease tumor proliferation. S-transferase P1-1 is an enzyme that is overexpressed in many human malignancies.|
|Synonyms||Telcyta; TER 286; TLK 286; N5-(((2-((bis(bis(2-chloroethyl)amino)phosphoryl)oxy)ethyl)sulfonyl)-D-alanyl)-N5-((R)-carboxy(phenyl)methyl)-L-glutamine hydrochloride;|
|Solubility||Soluble in DMSO|
|Storage||Store at -20 °C|
|Application||Glutathione transferase inhibitor|
|Quality Standard||Enterprise standard|
|Shelf Life||As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly.|
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