Candesartan Cilexetil - CAS 145040-37-5
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1. Systematic development of novel cationic self-nanoemulsifying drug delivery systems of candesartan cilexetil with enhanced biopharmaceutical performance
Gajanand Sharma, Sarwar Beg, Kaushik Thanki, Sanyog Jain,* Bhupinder Singh*. RSC Adv.,2015, 5,71500–71513
Candesartan cilexetil is popularly recommended for the treatment and management of hypertension. However, its therapeutic efficacy gets markedly reduced owing to low oral bioavailability as a function of poor solubility, extensive hepatic first-pass effect and high P-glycoprotein (P-gp) efflux. Several formulation strategies including solid dispersions, cosolvates, nclusion complexes and nanosuspensions have been under-taken to enhance the oral bioavailability of candesartan cilexetil. However, none of these formulations are found to be highly effective to address the low oral bioavailability issues, as these tend to deal with the poor solubility issue only. Lately, self-nanoemulsifying drug delivery systems (SNEDDS) have been extensively investigated for augmenting the oral absorption of highly lipophilic drugs owing to their inherent potential to improve drug solubility and permeability, and eventually its oral bioavailability.
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