Camylofine dihydrochloride - CAS 54-30-8
Catalog number:
54-30-8
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C19H32N2O2.2ClH
Molecular Weight:
393.4
COA:
Inquire
Targets:
mAChR
Description:
Camylofine dihydrochloride is an antimuscarinic used as a smooth muscle relaxant.
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Purity:
≥95%
Appearance:
White solid
Synonyms:
Camylofin dihydrochloride; 3-Methylbutyl {[2-(diethylamino)ethyl]amino}(phenyl)acetate dihydrochloride;
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
An antimuscarinic
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
InChIKey:
ZHRVNCCPAKIGRH-UHFFFAOYSA-N
InChI:
1S/C19H32N2O2.2ClH/c1-5-21(6-2)14-13-20-18(17-10-8-7-9-11-17)19(22)23-15-12-16(3)4;;/h7-11,16,18,20H,5-6,12-15H2,1-4H3;2*1H
Canonical SMILES:
CCN(CC)CCNC(C1=CC=CC=C1)C(=O)OCCC(C)C.Cl.Cl
1.Development and characterization of colon specific drug delivery system bearing 5-ASA and Camylofine dihydrochloride for the treatment of ulcerative colitis.
Dubey R1, Dubey R, Omrey P, Vyas SP, Jain SK. J Drug Target. 2010 Sep;18(8):589-601. doi: 10.3109/10611860903572933.
The treatment of ulcerative colitis (inflammatory bowel disease, IBD) has been achieved by using colon specific drug delivery system bearing 5-ASA and Camylofine dihydrochloride. Chitosan microspheres were prepared separately for both the drugs using emulsion method followed by enteric coating with EudragitS-100. The in vitro drug release was investigated in different simulated GIT medium. The drug release in PBS (pH7.4) and simulated gastric fluid has shown almost similar pattern and rate, whereas a significant increase in drug release (70.3 +/- 1.36 and 72.5 +/- 1.33% of 5-ASA and Camylofine, respectively) was observed in medium containing 3% rat caecal matter, after 24 h. In control study, 57.1 +/- 1.13% of 5-ASA and 59.2 +/- 1.2% of Camylofine release was observed in 24 h. For enzyme induction, rats were orally administered with 1 mL of 1% w/v dispersion of chitosan for 5 days and release rate studies were conducted in SCF with 3% w/v of caecal matter.
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CAS 54-30-8 Camylofine dihydrochloride

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