Camostat Mesilate - CAS 59721-29-8
Catalog number: 59721-29-8
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C20H22N4O5.CH4O3S
Molecular Weight:
494.52
COA:
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Targets:
Others
Description:
Camostat (INN) or FOY-305 is a serine protease inhibitor. Serine protease enzymes have a variety of functions in the body, and so camostat has a diverse range of uses. It is used in the treatment of some forms of cancer and is also effective against some viral infections, as well as inhibiting fibrosis in liver or kidney disease orpancreatitis.
Purity:
>98%
Related CAS:
59721-28-7 (Free base)
Appearance:
Solid powder
Synonyms:
4-(2-(2-(dimethylamino)-2-oxoethoxy)-2-oxoethyl)phenyl 4-guanidinobenzoate methanesulfonate; Camostat Mesilate; Camostat Mesylate; FOY 305; FOY-305; FOY305
MSDS:
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InChIKey:
FSEKIHNIDBATFG-UHFFFAOYSA-N
InChI:
1S/C20H22N4O5.CH4O3S/c1-24(2)17(25)12-28-18(26)11-13-3-9-16(10-4-13)29-19(27)14-5-7-15(8-6-14)23-20(21)22;1-5(2,3)4/h3-10H,11-12H2,1-2H3,(H4,21,22,23);1H3,(H,2,3,4)
Canonical SMILES:
O=C(OCC(N(C)C)=O)CC1=CC=C(OC(C2=CC=C(NC(N)=N)C=C2)=O)C=C1.CS(=O)(O)=O
1.The serine protease inhibitor camostat inhibits influenza virus replication and cytokine production in primary cultures of human tracheal epithelial cells.
Yamaya M1, Shimotai Y2, Hatachi Y3, Lusamba Kalonji N4, Tando Y5, Kitajima Y6, Matsuo K7, Kubo H4, Nagatomi R6, Hongo S2, Homma M8, Nishimura H8. Pulm Pharmacol Ther. 2015 Aug;33:66-74. doi: 10.1016/j.pupt.2015.07.001. Epub 2015 Jul 10.
BACKGROUND: Serine proteases act through the proteolytic cleavage of the hemagglutinin (HA) of influenza viruses for the entry of influenza virus into cells, resulting in infection. However, the inhibitory effects of serine protease inhibitors on influenza virus infection of human airway epithelial cells, and on their production of inflammatory cytokines are unclear.
2.Inhibition of Protease-ENaC Signaling Improves Mucociliary Function in Cystic Fibrosis Airways.
Reihill JA1, Walker B2, Hamilton RA3, Ferguson TE4, Elborn JS5, Stutts MJ6, Harvey BJ7, Saint-Criq V8, Hendrick SM9, Martin SL10. Am J Respir Crit Care Med. 2016 Mar 25. [Epub ahead of print]
RATIONALE: In cystic fibrosis (CF) a reduction in airway surface liquid (ASL) height compromises mucociliary clearance, favoring mucus plugging and chronic bacterial infection. Inhibitors of ENaC have therapeutic potential in CF airways to reduce the hyper-stimulated sodium and fluid absorption to levels which can restore airways hydration.
3.Membrane-anchored Serine Protease Matriptase Is a Trigger of Pulmonary Fibrogenesis.
Bardou O1,2, Menou A1,2, François C1,2, Duitman JW3, von der Thüsen JH4, Borie R2,5, Sales KU6,7, Mutze K8, Castier Y9, Sage E10, Liu L11, Bugge TH6, Fairlie DP11, Königshoff M8, Crestani B1,2,5, Borensztajn KS1,2. Am J Respir Crit Care Med. 2016 Apr 15;193(8):847-860.
RATIONALE: Idiopathic pulmonary fibrosis (IPF) is a devastating disease that remains refractory to current therapies.
4.Combination therapy with renin-angiotensin-aldosterone system inhibitor telmisartan and serine protease inhibitor camostat mesilate provides further renoprotection in a rat chronic kidney disease model.
Narita Y1, Ueda M2, Uchimura K3, Kakizoe Y2, Miyasato Y2, Mizumoto T2, Morinaga J2, Hayata M2, Nakagawa T2, Adachi M2, Miyoshi T2, Sakai Y4, Kadowaki D1, Hirata S1, Mukoyama M2, Kitamura K5. J Pharmacol Sci. 2016 Feb;130(2):110-6. doi: 10.1016/j.jphs.2016.01.003. Epub 2016 Jan 20.
We previously reported that camostat mesilate (CM) had renoprotective and antihypertensive effects in rat CKD models. In this study, we examined if CM has a distinct renoprotective effect from telmisartan (TE), a renin-angiotensin-aldosterone system (RAS) inhibitor, on the progression of CKD. We evaluated the effect of CM (400 mg/kg/day) and/or TE (10 mg/kg/day) on renal function, oxidative stress, renal fibrosis, and RAS components in the adenine-induced rat CKD model following 5-weeks treatment period. The combination therapy with CM and TE significantly decreased the adenine-induced increase in serum creatinine levels compared with each monotherapy, although all treatment groups showed similar reduction in blood pressure. Similarly, adenine-induced elevation in oxidative stress markers and renal fibrosis markers were significantly reduced by the combination therapy relative to each monotherapy. Furthermore, the effect of the combination therapy on plasma renin activity (PRA) and plasma aldosterone concentration (PAC) was similar to that of TE monotherapy, and CM had no effect on both PRA and PAC, suggesting that CM has a distinct pharmacological property from RAS inhibition.
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CAS 59721-29-8 Camostat Mesilate

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