Calcium Levofolinate - CAS 80433-71-2
Catalog number: 80433-71-2
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C20H21CaN7O7
Molecular Weight:
511.5
COA:
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Targets:
Antifolate
Description:
Calcium Levofolinate is a calcium salt of folinic acid that is an adjuvant used in cancer chemotherapy.
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Purity:
>98%
Synonyms:
Saponins
MSDS:
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1.[A case of multiple skin metastases from cancer of the descending colon responding to FOLFIRI/cetuximab therapy].
Kadota T1, Osuga T, Ogawa H, Kitami M, Ishimura M, Shigaki Y, Nakajima E, Nakata S, Kadota C, Hirano S, Ikura Y, Iwai Y, Yoshikawa T, Ueno N, Tamura T. Nihon Shokakibyo Gakkai Zasshi. 2014 Jan;111(1):115-23.
A 64-year-old woman presented to our hospital with subcutaneous tumors in the right thoracic region. After undergoing a thorough medical evaluation, she was diagnosed with multiple skin metastases arising from cancer of the descending colon. Surgical resection of the primary lesion was performed and FOLFIRI (5-fluorouracil, levofolinate calcium, irinotecan) and cetuximab chemotherapy for the metastases was initiated. The patient subsequently entered remission and did not experience any major side effects. This case report details an effective therapy for colon cancer with multiple skin metastases and presents a discussion of the expression profiles of epidermal growth factor receptor in both the primary and metastatic lesions.
2.[A case of nephrotic syndrome during TS-1 therapy after resection of rectal cancer and liver metastasis].
Sakagashira M, Yamada Y. Nihon Jinzo Gakkai Shi. 2014;56(4):538-44.
We report a case of a 63-year-old Japanese man who developed nephrotic syndrome during long-term TS-1 therapy, and was successfully treated with prednisolone (PSL). At 59 years of age, he underwent low anterior resection for rectal cancer, and resection of the lateral segment of the liver for metastasis, and cholecystectomy. He received chemotherapy with intravenous infusion of fluorouracil (5-FU) 500 mg, levofolinate calcium 350 mg, and hepatic arterial infusion of 5-FU 250 mg. After 6 cycles of 5-FU therapy, TS-1 therapy was started orally at 100 mg/day for 14 days followed by 7 days of rest. Edema appeared after 2 years. Urinary protein excretion was 6.38 g/day and hematuria was observed. His serum creatinine, total protein and albumin were 0.9 mg/dL, 4.9 g/dL and 2.6 g/dL, respectively. These data pointed to nephrotic syndrome. The renal pathology revealed segmental endocapillary proliferative lesions. Postinfectious glomerulonephritis, lupus nephritis and atypical IgA nephropathy were raised for differential diagnosis based on the pathology results.
3.SFPO and ESOP recommendations for the practical stability of anticancer drugs: an update.
Vigneron J1, Astier A, Trittler R, Hecq JD, Daouphars M, Larsson I, Pourroy B, Pinguet F; French Society of Hospital Pharmacists; European Society of Oncology Pharmacists. Ann Pharm Fr. 2013 Nov;71(6):376-89. doi: 10.1016/j.pharma.2013.06.002. Epub 2013 Aug 28.
The recommendations for the practical stability of anticancer drugs published in 2010 by the French Society of Hospital Pharmacists (SFPO) and the European Society of Oncology Pharmacists (ESOP) have been updated. Ten new molecules have been included (asparaginase, azacitidine, bevacizumab, clofarabine, eribuline mesylate, folinate sodium, levofolinate calcium, nelarabine, rituximab, temsirolimus).
4.[A case of esophageal cancer associated with colon cancer successfully treated with combination chemotherapy of FOLFOX and concurrent radiotherapy].
Watanabe Y1, Tsutsui M, Takeda S, Yoshino S, Oka M. Gan To Kagaku Ryoho. 2009 Nov;36(12):2439-41.
The standard chemotherapy regimen for esophageal cancer is cisplatin and 5-fluorouracil (5-FU). We herein report a case of esophageal cancer associated with colon cancer, which was treated with combination chemotherapy of FOLFOX. The patient received chemotherapy of modified FOLFOX6 (mFOLFOX6) at dosages of 80% of standard regimen (oxaliplatin 68 mg/m2, levofolinate calcium 160 mg/m2, bolus 5-FU 320 mg/m2, and followed by continuous 5-FU 1,920 mg/m2/ 46 hr) in combination with radiotherapy (total 61.6 Gy). He developed grade 3 leukopenia after 2 courses of mFOLFOX6 and the 3rd course was started at dosages of 70% of standard regimen with 1 week delay. After that, no other adverse event without grade 2 esophagitis was appeared. Esophagogram revealed a partial response in primary tumor of the esophagus after 3 courses of chemotherapy with radiotherapy and blood chemistry examination showed negative squamous cell carcinoma antigen. One month after chemoradiotherapy, esophagogram revealed tracheoesophageal fistula, but tumor of the esophagus was well controlled.
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CAS 80433-71-2 Calcium Levofolinate

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