1.Elevated Lifetime Lead Exposure Impedes Osteoclast Activity and Produces an Increase in Bone Mass in Adolescent Mice.
Beier EE1, Holz JD2, Sheu TJ3, Puzas JE4. Toxicol Sci. 2016 Feb;149(2):277-88. doi: 10.1093/toxsci/kfv234. Epub 2015 Oct 30.
The heavy metal lead (Pb) has a deleterious effect on skeletal health. Because bone mass is maintained through a balance of bone formation and resorption, it is important to understand the effect of Pb levels on osteoblastic and osteoclastic activity. Pb exposure is associated with low bone mass in animal models and human populations; however, the correlation between Pb dosing and corresponding bone mass has been poorly explored. Thus, mice were exposed to increasing Pb and at higher levels (500 ppm), there was unexpectedly an increase in femur-tibial bone mass by 3 months of age. This is contrary to several studies alluded to earlier. Increased bone volume (BV) was accompanied by a significant increase in cortical thickness of the femur and trabecular bone that extended beyond the epiphyseal area into the marrow cavity. Subsequent evaluations revealed an increase in osteoclast numbers with high Pb exposure, but a deficiency in osteoclastic activity.
2.The effect of 17β-estradiol on gene expression of calcitonin gene-related peptide and some pro-inflammatory mediators in peripheral blood mononuclear cells from patients with pure menstrual migraine.
Karkhaneh A1, Ansari M2, Emamgholipour S2, Rafiee MH3. Iran J Basic Med Sci. 2015 Sep;18(9):894-901.
OBJECTIVES: The neuropeptide calcitonin gene-related peptide (CGRP) has long been postulated to play an integral role in the pathophysiology of migraine. Earlier studies showed that CGRP can stimulate the synthesis and release of nitric oxide (NO) and cytokines from trigeminal ganglion glial cells. The purpose of this study was to determine the effect of 17β-estradiol in regulation of CGRP expression, inducible nitric oxide synthase (iNOS) activity, and NO and interleukin-1beta (IL-1β) release in cultured peripheral blood mononuclear cells (PBMCs) from patients with pure menstrual migraine and healthy individuals.
3.The influence of high volume hemofiltration on extra vascular lung water and alveolar-arterial oxygen pressure difference in patients with severe sepsis.
Jing F1, Wang J, Li M, Chu YF, Jiang JJ, Ding M, Wang YP, Wang CT, Ren HS. Eur Rev Med Pharmacol Sci. 2015 Oct;19(20):3792-800.
OBJECTIVE: To explore the effects of high-volume hemofiltration (HVHF) on the plasma interleukin-6 (IL-6), pro-calcitonin (PCT), extra vascular lung water index (EVLWI) and alveolar-arterial oxygen exchange in patients with septic shock.
4.Regional circulatory distribution of novel cardiac bio-markers and their relationships with haemodynamic measurements.
Pellicori P1, Goode KM2, Nicholls R2, Ahmed D2, Clark AL2, Cleland JG2. Int J Cardiol. 2016 May 1;210:149-55. doi: 10.1016/j.ijcard.2016.02.081. Epub 2016 Feb 15.
BACKGROUND: Regional sampling may identify sites of production or removal of novel biomarkers in the circulation; their relationship to haemodynamic measurements may clarify their association with the pathophysiology of heart failure.