Calcifediol - CAS 19356-17-3
Catalog number: 19356-17-3
Category: Inhibitor
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Molecular Formula:
C27H44O2
Molecular Weight:
400.64
COA:
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Targets:
VD/VDR
Description:
Calcifediol is a major circulating metabolite of vitamin D3 and acts as a competitive inhibitor with an apparent Ki of 3.9 μM. It also suppresses PTH secretion and mRNA (ED50=2 nM).
Purity:
>98%
Synonyms:
25-hydroxy Cholecalciferol; RO 8-8892; Rovimix Hy-D; U 32070E; 25-hydroxy Vitamin D3; 25-OH Vitamin D3; Calcifediol.
MSDS:
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InChIKey:
JWUBBDSIWDLEOM-UEGFJKGBSA-N
InChI:
InChI=1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23-,24-,25+,27-/m1/s1
Canonical SMILES:
CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C
1.Calcitriol/calcifediol ratio: An indicator of vitamin D hydroxylation efficiency?
Pasquali M1, Tartaglione L1, Rotondi S1, Muci ML1, Mandanici G1, Farcomeni A2, Marangella M3, Mazzaferro S1. BBA Clin. 2015 Mar 14;3:251-6. doi: 10.1016/j.bbacli.2015.03.004. eCollection 2015.
BACKGROUND: Calcifediol (25D) availability is crucial for calcitriol (1,25D) synthesis, but regulation of vitamin D hydroxylases is majorly responsible for 1,25D synthesis. The net efficiency of vitamin D hydroxylases might be informative. We assume that the ratio between calcitriol and calcifediol (25D/1,25D) serum concentrations could suggest the vitamin D hydroxylation efficiency.
2.[Vitamin D deficiency in chronic liver disease, clinical-epidemiological analysis and report after vitamin d supplementation].
Fernández Fernández N1, Linares Torres P2, Joáo Matias D2, Jorquera Plaza F2, Olcoz Goñi JL2. Gastroenterol Hepatol. 2015 Nov 16. pii: S0210-5705(15)00245-9. doi: 10.1016/j.gastrohep.2015.10.003. [Epub ahead of print]
INTRODUCTION: Vitamin D (VD) is known to have multiple extra-skeletal health functions. There is emerging interest in exploring the relationship between vitamin D and chronic liver disease (CLD).
3.[Study on levels of serum phosphorus, bone alkaline phosphatase and 25-hydroxyvitamin D in preterm infants with very low birth weight].
Tian Y1, Wu H2. Zhonghua Liu Xing Bing Xue Za Zhi. 2015 Nov;36(11):1288-90.
OBJECTIVE: To compare the levels of serum phosphorus, bone alkaline phosphatase and 25-hydroxyvitamin D3 in preterm infants with very low birth weight, and provide evidence for early screening, prevention of metabolic bone disease in preterm infants.
4.The clinical effect of vitamin D supplementation combined with grass-specific sublingual immunotherapy in children with allergic rhinitis.
Jerzynska J1, Stelmach W, Rychlik B, Lechańska J, Podlecka D, Stelmach I. Allergy Asthma Proc. 2016 Mar;37(2):105-14. doi: 10.2500/aap.2016.37.3921.
BACKGROUND: An important issue in sublingual immunotherapy (SLIT) is how to improve efficacy.
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