Cabraleahydroxylactone - CAS 35833-69-3
Catalog number: 35833-69-3
Not Intended for Therapeutic Use. For research use only.
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Cabraleahydroxylactone isolated from the herbs of Aglaia lawii.
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(5S)-5-[(3α,5α,17β)-3-Hydroxy-4,4,8,10,14-pentamethylgonan-17-yl] -5-methyldihydro-2(3H)-furanone; 3-hydroxy-25,26,27-trinordammaran-24,20-olide;
antiviral activity
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1.Activity-guided isolation of cytotoxic constituents from the bark of Aglaia crassinervia collected in Indonesia.
Su BN;Chai H;Mi Q;Riswan S;Kardono LB;Afriastini JJ;Santarsiero BD;Mesecar AD;Farnsworth NR;Cordell GA;Swanson SM;Kinghorn AD Bioorg Med Chem. 2006 Feb 15;14(4):960-72. Epub 2005 Oct 10.
Activity-guided fractionation of a CHCl(3)-soluble partition of the MeOH extract of the bark of Aglaia crassinervia collected in Indonesia led to the isolation of three new glabretal-type triterpenoids, aglaiaglabretols A-C (1-3), as well as nine known compounds, 3-epi-cabraleahydroxylactone (4), cabraleahydroxylactone (5), rocaglaol (6), 2beta,3beta-dihydroxy-5alpha-pregn-17(20)-(E)-16-one, scopoletin, and mixtures of cabraleadiol and epicotillol and of beta-sitosterol and stigmasterol. The structures of compounds 1-3 were determined on the basis of spectroscopic and chemical methods. The structure of aglaiaglabretol A (1) was confirmed by single-crystal X-ray analysis, and the absolute stereochemistry of this isolate was established by the Mosher ester method. The cytotoxic activity of all isolates and several chemical transformation products obtained in the present study was evaluated. The known cyclopenta[b]benzofuran, rocaglaol (6), was found to be significantly active and comparable in potency to the positive controls, paclitaxel and camptothecin. Aglaiaglabretol B (2) was further tested in an in vivo hollow fiber model.
2.A new sesquiterpene and other terpenoid constituents of Chisocheton penduliflorus.
Phongmaykin J;Kumamoto T;Ishikawa T;Suttisri R;Saifah E Arch Pharm Res. 2008 Jan;31(1):21-7.
A new aromadendrane sesquiterpene, allo-aromadendrane-10alpha, 14-diol (3), was isolated from Chisocheton penduliflorus (Meliaceae), along with two known sesquiterpenes: allo-aromadendrane-10beta, 14-diol (2) and allo-aromadendrane-10beta, 13, 14-triol (7). Six dammarane triterpenoids, including cabraleadiol (1), eichlerialactone (4), cabraleahydroxylactone (5), cabralealactone (6), hollongdione (8) and dammaradienone (9), the coumarins scoparone and scopoletin, and vanillic acid were also isolated from the wood and leaves of this plant. Compounds 1-7 displayed antimycobacterial activity against Mycobacterium tuberculosis. Compounds 1, 4, 5 and 6 were weakly cytotoxic to a breast cancer (BC) cell line; whereas, compound 6 was moderately active against a small-cell lung cancer (NCI-H187) cell line.
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CAS 35833-69-3 Cabraleahydroxylactone

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